Rapid Migration of¹¹¹Indium-Labeled Granulocytes to Sites of Infection

Augmentation of Human Polymorphonuclear Leukocyte Adherence by Interferon

“…This has been previously shown for lymphocyte natural killer activity [21] and conforms to data from molecular studies that each type of IFN binds to dif ferent receptors [20], PM Ns are phagocytic cells with vital roles in host resistance and inflammation [30,31]. They are among the first cells to congregate at sites of infection, arriv ing within 30 min as shown by radiolabelling [32], It has also been shown that their arrival within the first 2-4 h is critical for the control of infection [33]. It is, therefore, not surprising that there is interaction be tween IFN and PMN, since IFN is produced very early in the course of viral infections [34], and a viri cidal effect has been demonstrated for PM Ns [30,35].…”

Granulocyte transfusions in the G-CSF era. Where do we stand?

“…61 Leucocyte incompatibility may also inhibit the migration of the transfused neutrophils to sites of infection. [62][63][64] Leucocyte compatibility may be measured in several ways including HLA class I typing, screening for recipient HLA or granulocyte-specific antibodies or direct donor/recipient leucocyte cross matching. These various methods have been studied for their impact on the outcome of GTX mobilised with agents other than G-CSF, but the results are conflicting.…”

“…These various methods have been studied for their impact on the outcome of GTX mobilised with agents other than G-CSF, but the results are conflicting. 58,59,[61][62][63][64][65] In more recent studies employing G-CSF mobilised GTX, the method of leucocyte compatibility testing have been variable and in some studies either not performed or not reported. 34,50,57 The use of a screening lymphocytotoxicity assay prior to the provision of four prophylactic GTX (from the same donor) to patients undergoing autologous stem cell transplantation was found to predict for lower neutrophil increments following the last two GTX.…”

Granulocyte Transfusion Therapy for Treatment of Infections after Cytotoxic Chemotherapy

“…However, in certain circumstances, granulocyte transfusion therapy has been employed prophylactically to prevent infectious complications in high-risk patients [25,46,47]. Widespread use of this practice is limited by logistical difficulties, costs, and risk of alloimmunization and delayed engraftment upon subsequent hematopoietic stem cell transplantation [25,[48][49][50].…”