Rapid molecular diagnosis of the Mycobacterium tuberculosis Rangipo strain responsible for the largest recurring TB cluster in New Zealand

Mulholland, Claire V.; Ruthe, Ali; Cursons, Raymond T.; Durrant, Robert J.; Karalus, Noel; Coley, Kathryn; Bower, James E.; Permina, Elizabeth; Coleman, Michele; Roberts, Sally; Arcus, Vickery L.; Cook, Gregory M.; Aung, Htin

doi:10.1016/j.diagmicrobio.2017.03.012

Cited by 6 publications

(5 citation statements)

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“…We first performed single nucleotide polymorphism (SNP) based lineage assignment on 34 New Zealand Mtb Rangipo, Otara and Southern Cross strain genomes, these included sequences from previous work (Gautam et al, 2017;Mulholland et al, 2017) and new sequencing data. This assigned Rangipo and Otara isolates to the L4.4.1.1 (S-type) sublineage and Southern Cross to L4.3.3 (LAM).…”

Section: Phylogeny Of the New Zealand Mtb Strainsmentioning

confidence: 99%

“…We have recently sequenced 18, seven and five Mtb isolates from the New Zealand Rangipo, Otara and Southern Cross clusters, respectively, on the Illumina MiSeq platform (Mac Aogáin et al, 2016;Gautam et al, 2017;Mulholland et al, 2017). An additional four Rangipo genomes were sequenced for this study using paired-end 250-bp reads on the Illumina MiSeq platform using the Nextera TM XT DNA Library Preparation Kit (Illumina Inc., CA, United States) as previously described (Aung et al, 2016).…”

Section: New Zealand L44 Genomesmentioning

confidence: 99%

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Dispersal of Mycobacterium tuberculosis Driven by Historical European Trade in the South Pacific

et al. 2019

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Mycobacterium tuberculosis (Mtb) is a globally distributed bacterial pathogen whose population structure has largely been shaped by the activities of its obligate human host. Oceania was the last major global region to be reached by Europeans and is the last region for which the dispersal and evolution of Mtb remains largely unexplored. Here, we investigated the evolutionary history of the Euro-American L4.4 sublineage and its dispersal to the South Pacific. Using a phylodynamics approach and a dataset of 236 global Mtb L4.4 genomes we have traced the origins and dispersal of L4.4 strains to New Zealand. These strains are predominantly found in indigenous Māori and Pacific people and we identify a clade of European, likely French, origin that is prevalent in indigenous populations in both New Zealand and Canada. Molecular dating suggests the expansion of European trade networks in the early 19th century drove the dispersal of this clade to the South Pacific. We also identify historical and social factors within the region that have contributed to the local spread and expansion of these strains, including recent Pacific migrations to New Zealand and the rapid urbanization of Māori in the 20th century. Our results offer new insight into the expansion and dispersal of Mtb in the South Pacific and provide a striking example of the role of historical European migrations in the global dispersal of Mtb.

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Section: Phylogeny Of the New Zealand Mtb Strainsmentioning

confidence: 99%

Section: New Zealand L44 Genomesmentioning

confidence: 99%

Dispersal of Mycobacterium tuberculosis Driven by Historical European Trade in the South Pacific

et al. 2019

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“…; n = 2) were the species most represented in the literature. The most investigated pathogen is M. bovis because of its wide distribution and the high prevalence of TB in New Zealand (de Lisle et al., 2008; Mulholland et al., 2017; Nugent et al., 2012).…”

Section: Resultsmentioning

confidence: 99%

The importance of long‐term studies on wildlife diseases and their interfaces with humans and domestic animals: A review

Barroso

Acevedo

Vicente

2020

Transbound Emerg Dis

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Shared infections at the human and animal interfaces are caused by transmissible pathogens where at least one host species from either can be relevant for infection maintenance (e.g. Haydon et al., 2002). Many of the wildlife infections shared with livestock are also zoonotic (Chan et al., 2013;Cleaveland et al., 2001), and therefore, all interfaces are potential sources of disease emergence for humans (Jones et al., 2008;Wolfe et al., 2007). In the last few decades, several factors such as the changes in wildlife management, in land uses, in farming practices and/or in human demography have led to an expansion and increased abundance of wildlife

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“…We have recently sequenced eighteen, five and seven Mtb isolates from the New Zealand Rangipo, Southern Cross and Otara clusters, respectively, on the Illumina MiSeq platform [53–55]. In this study, we sequenced a further four Rangipo genomes on Illumina MiSeq as previously described [56].…”

Section: Methodsmentioning

confidence: 99%

Dispersal ofMycobacterium tuberculosisto indigenous populations driven by historical European trade in the South Pacific

Shockey

et al. 2019

Preprint

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27The Mycobacterium tuberculosis complex lineage 4 (L4), also known as the "Euro-American" 28 lineage, is the most widely dispersed of the seven human adapted lineages. L4 is comprised of ten 29 sublineages including L4.4, which has a moderate global distribution and is the most common L4 30 sublineage in New Zealand. We have used a phylodynamics approach and a dataset of 236 global 31 M. tuberculosis genomes to trace the origins and dispersal of L4.4 strains in New Zealand that are 32 predominantly found in Māori and Pacific people. We identify an L4.4.1.1 sublineage clade of 33 European origin, likely French, that is prevalent in indigenous populations in both New Zealand and 34 Canada. Molecular dating suggests that expansion of European trade networks in the early 19th 35 century led to dispersal of this clade to the South Pacific. We also identify historical and social factors 36 within the region that have contributed to the local spread and expansion of these strains, including 37 recent Pacific migrations to New Zealand and the rapid urbanization of Māori in the 20th century. Our 38 results offer new insight into the dispersal of M. tuberculosis in the South Pacific region and provide 39 a striking example of the role of historical European migrations in the dispersal of M. tuberculosis. 40 41 Author Summary 42 Tuberculosis kills more people worldwide than any other infectious disease and indigenous 43 populations are disproportionately affected by the disease. Here, we have used a large global dataset 44 of Mycobacterium tuberculosis bacterial genomes to trace the historical origins of tuberculosis strains 45 in New Zealand that are most frequently found in Māori and Pacific people. These strains are locally 46 known as the 'Rangipo' and 'Otara' strains (both Māori place names) and belong to the 47 "Euro-American" lineage of M. tuberculosis. Via genome analysis, we find that these strains are 48 closely related to M. tuberculosis strains found in indigenous populations in Canada that have a 49 European origin. We used a molecular dating approach (a molecular clock) to infer the ages of these 50 strains and date divergence events. The timing we infer corresponds to the introduction of these strains 3 51 to Polynesia via expanding European trade networks in the South Pacific in the early 19th century and 52 suggests that the Otara strain has migrated to New Zealand from the Pacific Islands multiple times. 53 Our results provide insight into human social phenomena underlying the expansion and dispersal of 54 M. tuberculosis and reassert the important role of European colonial migrations in the global dispersal 55 of the M. tuberculosis Euro-American lineage. This work also highlights the pejorative and 56 stigmatizing mislabelling of the New Zealand strains with indigenous Māori place names, suggesting 57 that these strains should be renamed. 58 59 Introduction 60 Tuberculosis (TB) is caused by the bacterial pathogen Mycobacterium tuberculosis (Mtb) and 61 other members of the Mtb complex (MTBC). TB kills m...

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Rapid molecular diagnosis of the Mycobacterium tuberculosis Rangipo strain responsible for the largest recurring TB cluster in New Zealand

Cited by 6 publications

References 6 publications

Dispersal of Mycobacterium tuberculosis Driven by Historical European Trade in the South Pacific

Dispersal of Mycobacterium tuberculosis Driven by Historical European Trade in the South Pacific

The importance of long‐term studies on wildlife diseases and their interfaces with humans and domestic animals: A review

Dispersal ofMycobacterium tuberculosisto indigenous populations driven by historical European trade in the South Pacific

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