Rapid multiresidue determination of organochlorine and organophosphorus compounds in human serum by solid-phase extraction and gas chromatography coupled to tandem mass spectrometry

Pitarch, Elena; Serrano, Roque; López, Francisco J.; Hernández, Félix

doi:10.1007/s00216-003-1893-2

Cited by 60 publications

(34 citation statements)

References 31 publications

(45 reference statements)

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“…[8][9][10] Recently, the newly developed surface-enhanced Raman scattering (SERS) method, using noble metal nanostructures as substrates, has attracted much attention because of its good performance on detection of trace amounts of organic pollutants. [11][12][13][14] This method has been applied successfully to the trace analysis and detection of PCBs by using nanorod arrays [15,16] and dendritic nanostructures [17] of Ag as SERS substrates.…”

Section: Introductionmentioning

confidence: 99%

Theoretical elucidation of the origin of surface‐enhanced Raman spectra of PCB52 adsorbed on silver substrates

Pan

Lai

Wang

et al. 2014

J Raman Spectroscopy

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To better understand experimentally observed surface-enhanced Raman Scattering (SERS) of polychlorinated biphenyls (PCBs) adsorbed on nanoscaled silver substrates, a systematic theoretical study was performed by carrying out density functional theory and time-dependent density functional theory calculations. 2,2′,5,5′-tetrachlorobiphenyl (PCB52) was chosen as a model molecule of PCBs, and Ag n (n = 2, 4, 6, and 10) clusters were used to mimic active sites of substrates. Calculated normal Raman spectra of PCB52-Ag n (n = 2, 4, 6, and 10) complexes are analogical in profile to that of isolated PCB52 with only slightly enhanced intensity. In contrast, the corresponding SERS spectra calculated at adopted incident light are strongly enhanced, and the calculated enhancement factors are 10 4~1 0 5 . Thus, the experimentally observed SERS phenomenon of PCBs supported on Ag substrates should correspond to the SERS spectra rather than the normal Raman spectra. The dominant enhancement in Raman intensities origins from the charge transfer resonance enhancement between the molecule and clusters.

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Section: Introductionmentioning

confidence: 99%

Theoretical elucidation of the origin of surface‐enhanced Raman spectra of PCB52 adsorbed on silver substrates

Pan

Lai

Wang

et al. 2014

J Raman Spectroscopy

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“…and cause severe health problems when they exceed the critical dose [1][2][3]. Currently, a combination of high-resolution gas chromatography and mass spectrometry is widely used as a powerful means for the detection of these compounds; this method is, however, expensive and time-consuming, and is not always able to distinguish isomers [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Rapid recognition of isomers of monochlorobiphenyls at trace levels by surface-enhanced Raman scattering using Ag nanorods as a substrate

Zhou

Yang

et al. 2010

Nano Res.

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Isomers and homologues of organic pollutants are hard to distinguish-especially in trace amounts-due to the similarities in their physical and chemical properties. We report here that by identifying the Raman characteristics of isomers of monochlorobiphenyls, these compounds can be recognized, even at trace levels, by using the surface-enhance Raman scattering method with silver nanorods as a substrate. When dissolved in acetone, 2-, 3-, and 4-chlorobiphenyls were detected at a concentration of 10 -8 mol/L, at which their characteristic Raman peaks were visible. This study may provide a fast, simple, and sensitive method for the detection and recognition of organic pollutants such as polychlorinated biphenyls.

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“…This is the case with compounds such as polycyclic aromatic hydrocarbons (PAH) or organochlorinated (OC) or polyoxygenated compounds. Although GC-MS is a suitable technique for the selective and sensitive determination of PAHs [6] and OCs [7,8], the high molecular mass, polarity, and low volatility of polyoxygenated compounds prevents the use of this approach [9].…”

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confidence: 99%

Evaluation of different quantitative approaches for the determination of noneasily ionizable molecules by different atmospheric pressure interfaces used in liquid chromatography tandem mass spectrometry: Abamectin as case of study

Grimalt

Pozo

Marín

et al. 2005

J. Am. Soc. Mass Spectrom.

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The liquid chromatography tandem mass spectroscopy residue determination of compounds without any acidic or basic centers such as abamectin has been investigated. Several approaches regarding the interface used and adduct formation have been compared. The low acidity of the hydroxyl groups only made deprotonation feasible using the atmospheric pressure chemical ionization (APCI) interface. To obtain sufficient sensitivity for residue analysis, the Ion Sabre APCI interface was necessary. However, the sensitivity attained was lower than for monitoring adducts in positive ion mode. Using electrospray ionization, different adducts with Na ϩ , NH 4 ϩ , and Li ϩ were tested and compared. The best results were obtained for the ammoniated adduct in electrospray ionization (ESI) because of its high sensitivity and the presence of several product ions with similar abundance. The highest sensitivity was reached using an in-source fragment as precursor ion, leading to a limit of detection (LOD) of 2 g/L with low relative standard deviation. The relatively high abundance of other transitions allowed abamectin confirmation at concentrations close to the LOD (6 g/L). Alkali ions were found to be a suitable alternative to determine and confirm abamectin at residue levels. The [M ϩ Na] ϩ also presented various product ions with similar abundance, which allowed confirmation at LOD levels. However, this LOD was found to be almost four times higher than with [M ϩ NH 4 ] ϩ because of the poor sensitivity of the transitions obtained. Although the use of Li ϩ facilitated the fragmentation of the adduct [M ϩ Li] ϩ , with similar sensitivity to [M ϩ NH 4 ] ϩ , this fragmentation preferentially generated only one product ion, which did not allow confirmation at concentration levels lower than 15 g/L. The use of APCI for monitoring adducts was also feasible, but with less sensitivity. The sensitivity increased with the Ion Sabre APCI, although it was still five times lower than with ESI. Other adduct formers such as Co 2ϩ and Ni 2ϩ also were tested with unsatisfactory results. (J Am Soc Mass Spectrom 2005, 16, 1619 -1630

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Rapid multiresidue determination of organochlorine and organophosphorus compounds in human serum by solid-phase extraction and gas chromatography coupled to tandem mass spectrometry

Cited by 60 publications

References 31 publications

Theoretical elucidation of the origin of surface‐enhanced Raman spectra of PCB52 adsorbed on silver substrates

Theoretical elucidation of the origin of surface‐enhanced Raman spectra of PCB52 adsorbed on silver substrates

Rapid recognition of isomers of monochlorobiphenyls at trace levels by surface-enhanced Raman scattering using Ag nanorods as a substrate

Evaluation of different quantitative approaches for the determination of noneasily ionizable molecules by different atmospheric pressure interfaces used in liquid chromatography tandem mass spectrometry: Abamectin as case of study

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