Rapid nongenomic actions of thyroid hormone

Hiroi, Yukio; Kim, Hyung Hwan; Ying, Hao; Furuya, Fumihiko; Huang, Zhihong; Simoncini, Tommaso; Noma, Kazuhiro; Ueki, Kojiro; Nguyen, Ngoc Ha; Scanlan, Thomas S.; Moskowitz, Michael A.; Cheng, Siyuan; Liao, James K.

doi:10.1073/pnas.0601600103

Cited by 345 publications

(277 citation statements)

References 42 publications

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“…24 -26 These T 3 -mediated effects include changes in various membrane ion channels for sodium, potassium, and calcium, effects on actin polymerization, adenine nucleotide translocator 1 in the mitochondrial membrane, and a variety of intracellular signaling pathways in the heart and vascular smooth muscle cells (VSM). [25][26][27] Together, the nongenomic and genomic effects of T 3 act in concert to regulate cardiac function and cardiovascular hemodynamics.…”

Section: Cellular Mechanisms Of Thyroidmentioning

confidence: 99%

“…Increased endothelial nitric oxide production may result, in part, from the T 3 -mediated effects of TR on the protein kinase akt pathway either via nongenomic or genomic mechanisms. 26,31 Nitric oxide synthesized in endothelial cells then acts in a paracrine manner on adjacent VSM cells to facilitate vascular relaxation. In hypothyroidism, arterial compliance is reduced, which leads to increased SVR.…”

Section: Effects Of Thyroid Hormone On Cardiovascular Hemodynamicsmentioning

confidence: 99%

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Thyroid Disease and the Heart

Klein¹,

Danzi²

2016

Current Problems in Cardiology

152

104

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Abstract-The cardiovascular signs and symptoms of thyroid disease are some of the most profound and clinically relevant findings that accompany both hyperthyroidism and hypothyroidism. On the basis of the understanding of the cellular mechanisms of thyroid hormone action on the heart and cardiovascular system, it is possible to explain the changes in cardiac output, cardiac contractility, blood pressure, vascular resistance, and rhythm disturbances that result from thyroid dysfunction. The importance of the recognition of the effects of thyroid disease on the heart also derives from the observation that restoration of normal thyroid function most often reverses the abnormal cardiovascular hemodynamics. In the present review, we discuss the appropriate thyroid function tests to establish a suspected diagnosis as well as the treatment modalities necessary to restore patients to a euthyroid state. We also review the alterations in thyroid hormone metabolism that accompany chronic congestive heart failure and the approach to the management of patients with amiodarone-induced alterations in thyroid function tests.

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Section: Cellular Mechanisms Of Thyroidmentioning

confidence: 99%

Section: Effects Of Thyroid Hormone On Cardiovascular Hemodynamicsmentioning

confidence: 99%

Thyroid Disease and the Heart

Klein¹,

Danzi²

2016

Current Problems in Cardiology

152

104

View full text Add to dashboard Cite

show abstract

“…T3 induced interaction of cytosolic thyroid hormone receptors with PI3 kinases was found in central endothelial cells in response to middle cerebral artery occlusion. This activation results via the Akt-pathway in a rapid induction of NO synthesis and a reduction in cerebral infarct size (Hiroi et al, 2006). Very rapid effects are also exerted by iodothyronines that do not bind to thyroid hormone receptors.…”

Section: Rapid Effects Of Thyroid Hormonementioning

confidence: 99%

Thyroid hormone action during brain development: More questions than answers

Horn

Heuer

2010

Molecular and Cellular Endocrinology

176

109

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“…Recently the non-genomic effect of TR was extensively studied by several research groups all over the world (Moeller et al, 2005;Hiroi et al, 2006;Furuya et al, 2007). It is not clear whether non-genomic effect of TR also plays a role in sustaining energy metabolism.…”

Section: Non-genomic Effect Of Trmentioning

confidence: 99%

Thyroid hormone action in metabolic regulation

2011

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Thyroid hormone plays pivotal roles in growth, differentiation, development and metabolic homeostasis via thyroid hormone receptors (TRs) by controlling the expression of TR target genes. The transcriptional activity of TRs is modulated by multiple factors including various TR isoforms, diverse thyroid hormone response elements, different heterodimeric partners, coregulators, and the cellular location of TRs. In the present review, we summarize recent advance in understanding the molecular mechanisms of thyroid hormone action obtained from human subject research, thyroid hormone mimetics application, TR isoform-specific knock-in mouse models, and mitochondrion study with highlights in metabolic regulations. Finally, as future perspectives, we share our thoughts about current challenges and possible approaches to promote our knowledge of thyroid hormone action in metabolism.

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Rapid nongenomic actions of thyroid hormone

Cited by 345 publications

References 42 publications

Thyroid Disease and the Heart

Thyroid Disease and the Heart

Thyroid hormone action during brain development: More questions than answers

Thyroid hormone action in metabolic regulation

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