Rapid octreotide separation from synthetic peptide crude mixtures by chromatography on poly(styrene–co-divinylbenzene)-based reversed phases

Zhang, Chenxu; Zhang, Rongyue; Li, Qiang; Huang, Yongdong; Zhao, Lan; Su, Zhiguo; Gong, Fangling; Lv, Zheng; Song, Hongjian; Li, Wei; Yuan, Qipeng; Ma, Guanghui

doi:10.1016/j.seppur.2015.09.050

Cited by 7 publications

(2 citation statements)

References 33 publications

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“…By direct membrane emulsification, the dispersed phase was forced through the membrane with the precisely controlled pressure and detached from the membrane under the flow of the continuous phase to form a homogeneous emulsion . The other technique was rapid membrane emulsification, where the coarse emulsion was formed under conventional agitation, and then, it was pressed through the membrane to form a homogeneous emulsion . The solvent was removed to form drug microspheres with a uniform size distribution for the drug delivery system.…”

Section: Introductionmentioning

confidence: 99%

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Improved Spherical Particle Preparation of Ceftriaxone Sodium via Membrane-Assisted Spherical Crystallization

Zhao

Xiao

et al. 2023

Ind. Eng. Chem. Res.

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Spherical drug particles prepared by the spherical crystallization technique can simultaneously improve the mobility of particles, mechanical properties, drug solubility and bioavailability, etc. However, high-efficient mixing of a solution and the formation of uniform bridging liquid droplets were crucial for accurate control of spherical crystallization processes. Herein, a novel membrane-assisted spherical crystallization (MASC) technology was proposed to produce monodisperse spherical agglomerates of ceftriaxone sodium. The poor solvent permeation rate of MASC was stabilized by adjusting the liquid flow velocity in the shell side and tube side. Uniform bridging liquid droplets constructed by a polytetrafluoroethylene hollow fiber membrane were observed in real time. A stable flow field and crystallization microenvironment were provided on the hollow fiber membrane surface. The crystal size distribution and the coefficient of variation of ceftriaxone sodium products were improved compared with those of conventional spherical crystallization (CSC) under the same stirring rate. The impurities of CSC products did not meet the requirements due to the degradation after 14 days’ acceleration experiment, while the one of MASC products still met the pharmacopoeia requirements after 30 days. This study provides a potential membrane-based technology for the enhancement of spherical crystallization of related drugs.

show abstract

Section: Introductionmentioning

confidence: 99%

“…40 The other technique was rapid membrane emulsification, where the coarse emulsion was formed under conventional agitation, and then, it was pressed through the membrane to form a homogeneous emulsion. 41 The solvent was removed to form drug microspheres with a uniform size distribution for the drug delivery system.…”

Section: Introductionmentioning

confidence: 99%

Improved Spherical Particle Preparation of Ceftriaxone Sodium via Membrane-Assisted Spherical Crystallization

Zhao

Xiao

et al. 2023

Ind. Eng. Chem. Res.

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show abstract

Applications of Uniform Microspheres and Super‐porous Microspheres in Biochemical Engineering

2023

Novel Membrane Emulsification

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Steady-migration retention characteristics of peptides under gradient elution: application towards a dynamic separation method for minor-adjustments of the retention of peptides in RPLC

Lü²,

Yang

et al. 2016

Sci. China Chem.

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Rapid octreotide separation from synthetic peptide crude mixtures by chromatography on poly(styrene–co-divinylbenzene)-based reversed phases

Cited by 7 publications

References 33 publications

Improved Spherical Particle Preparation of Ceftriaxone Sodium via Membrane-Assisted Spherical Crystallization

Improved Spherical Particle Preparation of Ceftriaxone Sodium via Membrane-Assisted Spherical Crystallization

Applications of Uniform Microspheres and Super‐porous Microspheres in Biochemical Engineering

Steady-migration retention characteristics of peptides under gradient elution: application towards a dynamic separation method for minor-adjustments of the retention of peptides in RPLC

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