Rapid On-site Evaluation of Spine Lesions

Akhtar, Israh; Manucha, Varsha

doi:10.1016/j.nic.2019.07.009

Cited by 2 publications

(3 citation statements)

References 23 publications

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“…Furthermore, intraoperative SBMA cytology as described by us can be performed as part of a rapid on-site evaluation (ROSE) [ 27 ]. This can provide a simple and cost-effective alternative to intraoperative cryosection procedures for rapid diagnosis, for which a diagnostic certainty of 89% was described [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Surgical Site Cytology to Diagnose Spinal Lesions

et al. 2022

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Patients with new-onset malignant spinal lesions often have an urgent need for local spine intervention and systemic therapy. For optimal management, it is crucial to diagnose the underlying disease as quickly and reliably as possible. The aim of our current study was to determine the feasibility, sensitivity, specificity, and diagnostic certainty of complementary cytological evaluation of spinal lesions suspected of malignancy. In 44 patients, we performed histopathological biopsies and in parallel cytologic preparations from the malignant site. Cytological smears were prepared and stained for May-Grunwald and Giemsa. Bone biopsies were histopathologically analyzed according to the existing standard-of-care practices. In 42 of 44 cases (95%), a cytological sample was successfully obtained. In 40 cases (95.2%, Cohen’s kappa: 0.77), the cytological diagnosis agreed with the histological diagnosis regarding the identification of a malignant lesion. This resulted in a sensitivity of 97% and a specificity of 80% as well as a diagnostic safety of 95%. Cytological analysis in the context of spinal surgery proved sufficient to establish a diagnosis of malignancy or its exclusion, expanding the existing diagnostic spectrum. Furthermore, implementation of this process as a routine clinical diagnostic might shorten the time to diagnosis and improve the treatment of this vulnerable patient group.

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Section: Discussionmentioning

confidence: 99%

Surgical Site Cytology to Diagnose Spinal Lesions

et al. 2022

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“…Thin needle biopsy is performed when the tumor is located in paraspinal areas, and core needle biopsy is executed when the bone is affected by neoplasm. The sensitivity of the biopsy is defined in 93.3–96% [ 49 ].…”

Section: Diagnosticsmentioning

confidence: 99%

“…The percutaneous biopsy is an elegant alternative to open biopsy [47]. Thin needle biopsy (with needle [22][23][24][25] or core needle biopsy (with needle 11-15) are performed under control of X-ray, CT, or ultrasonography with local anesthesia [49,50]. Ideally, the histopathologist is present during the procedure and directly evaluates the obtained material under microscopy, which guarantees the utility of the sample for further diagnostics.…”

Section: Invasive Diagnostics-biopsymentioning

confidence: 99%

Holistic Approach to the Diagnosis and Treatment of Patients with Tumor Metastases to the Spine

Nowak

Szwacka

Pater

et al. 2022

Cancers

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The treatment of neoplastic spine metastases requires multi-faceted assessment and an interdisciplinary approach to patients. The metastases do not show specific symptoms but are often the first confirmation of the presence of a primary tumor in a patient. The diagnostic process includes imaging and invasive procedures, e.g., biopsy. It is essential to qualify the patient for an appropriate treatment using dedicated scales. Decompression of the spinal cord is a critical issue to save or restore neurological function in a patient with spine metastases. Surgical treatment ought to meet three criteria: release spinal cord and nerve roots, restore the spine’s anatomical relations, and ensure the internal stabilization of the spine. A good result from surgical treatment enables the continuation of radiotherapy, chemotherapy, hormone therapy, and targeted molecular therapy. Stereotactic radiosurgery and stereotactic body radiotherapy are more effective ways of treating spine metastases than conventional external beam radiotherapy. They allow higher doses of radiation, concentrated precisely at the tumor site. Our review summarizes the established and emerging concepts in the treatment of spine metastases. A holistic approach to the patient enables the selection of the appropriate therapy.

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Rapid On-site Evaluation of Spine Lesions

Cited by 2 publications

References 23 publications

Surgical Site Cytology to Diagnose Spinal Lesions

Surgical Site Cytology to Diagnose Spinal Lesions

Holistic Approach to the Diagnosis and Treatment of Patients with Tumor Metastases to the Spine

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