Rapid Onset and Fatal Outcome of Two Squamous Cell Carcinomas of the Genitalia in a Patient Treated with Etanercept for Cutaneous Psoriasis

Comte, C.; Guilhou, Jean‐Jacques; Guillot, B.; Dereure, O.

doi:10.1159/000150603

Cited by 23 publications

(13 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This has to be underlined because infliximab, etanercept and adalimumab appear to be new approaches in severe extensive forms of HS [55,56,57,58]. So, in HS, as Comte et al [59 ]described in psoriasis, we recommend to check for HPV lesions before considering anti-TNF-α treatment. This observation is illustrated by the case report of Maalouf et al [32], who described a fatal SCC complicating HS localization after 5 infusions of infliximab.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Study of 13 Cases of Squamous Cell Carcinoma Complicating Hidradenitis Suppurativa

et al. 2009

View full text Add to dashboard Cite

Background: To the best of our knowledge, only 52 cases of squamous cell carcinoma (SCC) complicating hidradenitis suppurativa (HS) have been reported since 1958. We describe 13 new cases. Methods: We propose a clinical and histological analysis of our cases. We include these results in a review of previously reported cases to analyze a total of 65 patients. In our series of 13 cases, we also investigate the presence of human papillomavirus (HPV) in tumor samples, by polymerase chain reaction (PCR) on paraffin-embedded material. Results: Malignant transformation affects mainly men with a long-term history of genitoanal HS. Although our cases were 7 well-differentiated carcinomas and 6 verrucous carcinomas, lymphatic and visceral metastasis occurred in 2 and 3 cases, respectively. With PCR, we demonstrated presence of HPV in genitoanal tumoral lesions, principally HPV-16. Conclusion: SCC complicating HS evolves poorly, despite a good histological prognosis. Our results sustain the implication of HPV in the malignant transformation of HS.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinicopathological Study of 13 Cases of Squamous Cell Carcinoma Complicating Hidradenitis Suppurativa

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Several reports have discussed the apparent association of etanercept and rapid development of SCCs. [6][7][8][9][10] Two reported rapid onset of SCC on the penis in patients with psoriasis treated with etanercept. 7,8 One of these reported a fatal outcome due to penile SCC.…”

Section: Discussionmentioning

confidence: 99%

“…[6][7][8][9][10] Two reported rapid onset of SCC on the penis in patients with psoriasis treated with etanercept. 7,8 One of these reported a fatal outcome due to penile SCC. 7 In another patient receiving a combination of acitretin and etanercept, SCC and non-Hodgkin lymphoma developed.…”

Section: Discussionmentioning

confidence: 99%

Multiple squamous cell carcinomas in the setting of psoriasis treated with etanercept: a report of four cases and review of the literature

2011

View full text Add to dashboard Cite

show abstract

“…The majority of these drugs directly target pro-inflammatory mediators whereas alefacept targets a critically important cellular interaction necessary for promotion of local inflammation 101 . Several case and cohort studies suggest that infliximab, etanercept, and adalimumab are associated with rapid development of NMSC, especially SCC 69,102–107 , and that etanercept and adalimumab are associated with resurgence of latent metastatic melanoma 108 . This connection may be related to disruption of cancer immunosurveillance and polarization of the immune response towards a Th2 cytokine profile, which is less able to control tumour growth 109,110 .…”

Section: Clinical Studies Linking Immunosuppression With Skin Cancermentioning

confidence: 99%

Roles of the immune system in skin cancer

Rangwala

Tsai

2011

British Journal of Dermatology

167

147

View full text Add to dashboard Cite

Over the past several decades, there has been increasing interest in understanding the roles of the immune system in the development and progression of cancer. The importance of the immune system in human skin cancer has been long recognised based primarily upon the increased incidence of skin cancers in organ transplant recipients and mechanisms of ultraviolet light-mediated immunomodulation. In this review, we integrate multiple lines of evidence highlighting the roles of the immune system in skin cancer. First, we discuss the concepts of cancer immunosurveillance and immunoediting as they might relate to human skin cancers. We then describe the clinical and molecular mechanisms of skin cancer development and progression in the contexts of therapeutic immunosuppression in organ transplant recipients, viral oncogenesis, and ultraviolet light-induced immunomodulation with a primary focus on basal cell carcinoma and squamous cell carcinoma. The clinical evidence supporting expanding roles for immunotherapy is also described. Finally, we discuss recent research examining the functions of particular immune cell subsets in skin cancer and how they might contribute to both anti-tumour and pro-tumour effects. A better understanding of the biological mechanisms of cancer immunosurveillance holds the promise of enabling better therapies.

show abstract

Rapid Onset and Fatal Outcome of Two Squamous Cell Carcinomas of the Genitalia in a Patient Treated with Etanercept for Cutaneous Psoriasis

Cited by 23 publications

References 8 publications

Clinicopathological Study of 13 Cases of Squamous Cell Carcinoma Complicating Hidradenitis Suppurativa

Clinicopathological Study of 13 Cases of Squamous Cell Carcinoma Complicating Hidradenitis Suppurativa

Multiple squamous cell carcinomas in the setting of psoriasis treated with etanercept: a report of four cases and review of the literature

Roles of the immune system in skin cancer

Contact Info

Product

Resources

About