2017
DOI: 10.1155/2017/6458676
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Rapid Onset of B12 Deficiency in the Setting of Worsening Multiple Myeloma: Correlations between B12 Deficiency and Multiple Myeloma

Abstract: A 67-year-old female with a relapse of multiple myeloma after being in remission for approximately 2 years following autologous stem cell transplant presented with worsening pancytopenia, over a three-month period. There were an increase in her monoclonal spike at 3.13 g/dL on serum protein electrophoresis, low serum B12 levels, and positive intrinsic factor antibodies. Three months before, she had normal B12 levels and a significantly lower monoclonal spike of 1.07 g/dL. She was diagnosed with B12 deficiency … Show more

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Cited by 3 publications
(6 citation statements)
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“…Multiple myeloma (MM) is a bone marrow-derived clonal plasma cell neoplasm that is characterized by the overproduction of monoclonal antibodies. 3 MM is a devastating disease where patients may develop renal failure, cytopenia, infections because of immunoparesis, electrolyte abnormalities like hypercalcemia, and lytic bone lesions manifesting as skeletal symptoms with back pain and vertebral fractures. 4 Extramedullary dissemination, a rare event, has also been noted with MM and carries a poor prognosis.…”
Section: Discussionmentioning
confidence: 99%
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“…Multiple myeloma (MM) is a bone marrow-derived clonal plasma cell neoplasm that is characterized by the overproduction of monoclonal antibodies. 3 MM is a devastating disease where patients may develop renal failure, cytopenia, infections because of immunoparesis, electrolyte abnormalities like hypercalcemia, and lytic bone lesions manifesting as skeletal symptoms with back pain and vertebral fractures. 4 Extramedullary dissemination, a rare event, has also been noted with MM and carries a poor prognosis.…”
Section: Discussionmentioning
confidence: 99%
“… 5 MM involving the CNS is a rare complication of MM occurring in roughly 1% of MM patients with an overall survival of less than 6 months. 5 Based on a review by Dispenzieri and Kyle, intracranial plasmacytomas or myelomas can be classified into four groups: 1 lesions extending from the skull and pressing inward, 2 lesions growing from the dura mater or the leptomeninges, 3 lesions from the mucous membranes of a nasopharyngeal plasmacytoma, and 4 intraparenchymal lesions not arising from any of these other sites. 6 Leptomeningeal involvement is the most common form, often leading to nerve root infiltration and cerebral nerve palsies.…”
Section: Discussionmentioning
confidence: 99%
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