Rapid onset of cervical cancer in an upper socioeconomic group

Bain, Robert W.; Crocker, Diane W.

doi:10.1016/0002-9378(83)90814-1

Cited by 33 publications

(17 citation statements)

References 3 publications

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“…The development of invasive carcinoma of the cervix within a relatively short time interval after a 'negative' Pap smear has been noted in a number of reports in the literature (2)(3)(4)(5)(6)(7)(8). Such series and case reports have added credence to the proposal suggested by Ashley in 1966 (1°) that there are two forms of cervical cancer.…”

Section: Discussionmentioning

confidence: 82%

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Cervical carcinoma after negative Pap smears: evidence against rapid-onset cancers

Wain

Farnsworth

Hacker

1992

International Journal of Gynecological Cancer

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Recently, suggestions have been made that a 'rapid-onset' type of cervical cancer is emerging. Evidence for this entity is based on the diagnosis of invasive cervical carcinoma within 2 or 3 years of a 'normal' Pap smear. Analysis of 237 patients presenting to our unit between November 1986 and July 1990 with the histologic diagnosis of invasive carcinoma of the cervix revealed 51 patients (21.5%) who reported having had a 'normal' Pap smear within 2 years of diagnosis. Strenuous efforts were made to verify and retrieve these smears in an attempt to isolate a group of 'rapid-onset' cancers. Despite the patients' claim to the contrary, there was no record of a smear being performed in 15 patients (29%). The slides of six patients could not be located either due to lack of laboratory co-operation or because the slides had been destroyed: four of these patients had very early adenocarcinomas. The slides of 30 patients were retrieved and reviewed: 16 slides reported as negative contained cells consistent with either invasive carcinoma or carcinoma in-situ; four cases had virtually no cellular material on the slide; four cases contained atypical cells but requests for further material were not followed-up. Six patients had previously been treated for pre-invasive lesions over a range of 3-18 years. We found no case of invasive carcinoma in a patient with a confirmed adequate negative smear within 2 years of diagnosis. At most, six patients (2.52%) could have had 'rapid-onset' cancers but this could not be confirmed as these slides could not be reviewed. In summary, this study suggests that in our patient population, 'rapid-onset' cervical carcinoma is rare.

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Section: Discussionmentioning

confidence: 82%

“…has been concerned with the apparent emergence of a rapid-onset type of cancer (2)(3)(4)(5)(6)(7)(8). Some reports have suggested the incidence of such an entity may be as high as 33-37% (4,5) .…”

mentioning

confidence: 99%

Cervical carcinoma after negative Pap smears: evidence against rapid-onset cancers

Wain

Farnsworth

Hacker

1992

International Journal of Gynecological Cancer

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“…Risk factors for HR-HPV infection and persistence were also examined, since risk of cervical carcinoma cannot be considered independent from them (21). Sexual history characteristics considered included lifetime number of sex partners (3) and serologic evidence of HSV-2 (15, 22) or C. trachomatis (19, 23, 24) infection. Reproductive history variables examined included age of first menses, combined oral contraceptive (OC) use (3, 25), and multiparity (15, 25, 26).…”

Section: Methodsmentioning

confidence: 99%

“…As sexual contact is thought to be the mode of transmission for virtually all anogential HPV infections (5), these estimates suggest that women diagnosed with SCC in their twenties or younger could have a very young age at first intercourse (AFI), perhaps as early as 10 or 12 years old. Early-onset SCC may also occur due to particularly rapid disease progression (10, 11), a controversial phenomenon (12). …”

Section: Introductionmentioning

confidence: 99%

Age of Diagnosis of Squamous Cell Cervical Carcinoma and Early Sexual Experience

Edelstein

Madeleine

Johnson

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Given the established links among young age at first intercourse (AFI), number of sex partners, high-risk human papillomavirus infection, and squamous cell cervical cancer (SCC), we hypothesized that women diagnosed with SCC at younger ages would be more likely to report young AFI than women diagnosed later in life. Methods: We performed a population-based investigation among invasive SCC cases who were diagnosed between 1986 and 2004, were ages 22 to 53 years, and lived in the metropolitan Seattle-Puget Sound region (n = 333). Using multivariate linear regression, we estimated coefficients and 95% confidence intervals (95% CI) to assess the association between age at SCC diagnosis and AFI (<15, 15-18, z19 years) and number of sex partners at age <20 years (0, 1, 2-4, 5-14, z15), accounting for birth year and other factors. Interactions were assessed using the likelihood ratio test.

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“…The average interval from the last negative Pap smear to a diagnosis of carcinoma in situ or invasive cancer was just over 2 yr. No distinctive characteristics have been found thus far to single out women who are at risk for rapidly developing cervical cancers. In one study, data was derived from cervical cancer patients among an upper socioeconomic group of women, who are generally considered to be at low risk [85]. No epidemiological studies have been conducted to distinguish patients susceptible to rapidly progressive cervical cancer from those with traditionally paced disease.…”

Section: Genetic Susceptibilitymentioning

confidence: 99%

Natural history of human papillomavirus infection of the anogenital tract

Lancaster

Jenson

1987

Cancer Metast Rev

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A number of viruses, most notably herpes virus type 2, have been suggested as etiological agents of cervical neoplasia. Recent studies with human papillomaviruses, however, have demonstrated a remarkable association of a subgroup of these viruses with about 90% of benign, preinvasive and invasive lesions of the cervix and anogenital tract. The oncogenic potential of papillomaviruses has been demonstrated both in laboratory animals and in cultured cells. Furthermore, susceptibility to certain human papillomaviruses has been associated with a recessive genetic defect that results in squamous cell carcinoma of the skin. The human papillomaviruses are difficult to study, however, because of the lack of an animal model, difficulty in developing a tissue culture system permissive for their replication, and a lack of understanding of their biology. Current understanding of the natural history of anogenital neoplasia may provide insights into the mechanisms the host uses to cope with potentially oncogenic human papillomaviruses.

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Rapid onset of cervical cancer in an upper socioeconomic group

Cited by 33 publications

References 3 publications

Cervical carcinoma after negative Pap smears: evidence against rapid-onset cancers

Cervical carcinoma after negative Pap smears: evidence against rapid-onset cancers

Age of Diagnosis of Squamous Cell Cervical Carcinoma and Early Sexual Experience

Natural history of human papillomavirus infection of the anogenital tract

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