Rapid Parallel Synthesis of Polymer-Bound Enones Utilizing Microwave-Assisted Solid-Phase Chemistry

and, Gernot A. Strohmeier; Kappe, C. Oliver

doi:10.1021/cc010043r

Cited by 85 publications

(53 citation statements)

References 51 publications

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“…[221] This approach required the synthesis of the 4-chloroacetoacetate resin as the key starting material, which was prepared by microwave-assisted acetoacetylation of hydroxymethyl polystyrene resin. In analogy to earlier work, [222] this transesterification was best carried out under open-vessel conditions in 1,2-dichlorobenzene (170 8C) to allow the formed methanol to be removed from the equilibrium (see also Scheme 20). This resin precursor was subsequently treated with urea and various aldehydes in an acid-catalyzed Biginelli multicomponent reaction (dioxane, 70 8C) to afford the corresponding resin-bound dihydropyrimidinones.…”

Section: Methodsmentioning

confidence: 99%

Controlled Microwave Heating in Modern Organic Synthesis

2004

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Although fire is now rarely used in synthetic chemistry, it was not until Robert Bunsen invented the burner in 1855 that the energy from this heat source could be applied to a reaction vessel in a focused manner. The Bunsen burner was later superseded by the isomantle, oil bath, or hot plate as a source for applying heat to a chemical reaction. In the past few years, heating and driving chemical reactions by microwave energy has been an increasingly popular theme in the scientific community. This nonclassical heating technique is slowly moving from a laboratory curiosity to an established technique that is heavily used in both academia and industry. The efficiency of “microwave flash heating” in dramatically reducing reaction times (from days and hours to minutes and seconds) is just one of the many advantages. This Review highlights recent applications of controlled microwave heating in modern organic synthesis, and discusses some of the underlying phenomena and issues involved.

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Section: Methodsmentioning

confidence: 99%

Controlled Microwave Heating in Modern Organic Synthesis

2004

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“…As dielectric heating is a bulk technique, it is faster than heating based on conduction. Moreover, yet unexplained and surprisingly high catalytic reaction rates have been reported [10][11][12][13][14][15][16]. The present objective is to assess the feasibility of using a microwave sensitive catalytic material as a soot filter coating.…”

Section: Introductionmentioning

confidence: 99%

Dielectric heating effects on the activity and SO2 resistance of La0.8Ce0.2MnO3 perovskite for methane oxidation

Zhang-Steenwinkel

Castricum

Beckers

et al. 2004

Journal of Catalysis

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Dielectric heating effects on the activity and SO2 resistance of La0.8Ce0.2MnO3 perovskite for methane oxidation Zhang, Y.; Castricum, H.L.; Beckers, J.; Eiser, E.; Bliek, A. General rightsIt is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. under dielectric and conventional heating conditions. As these materials are both microwave sensitive and catalytically active, they may be applied as coating material for ceramic soot filters for the reduction of soot emission from Diesel engines. Dielectric heating is shown to result in a much higher CH 4 conversion and a higher resistance to SO 2 poisoning. We propose that local hot spots on the catalytic surface explain the increased activity toward CH 4 conversion. The catalytic activity in SO 2 is largely maintained, as pore blockage by sulphates, as experienced in conventional heating, is counteracted.

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“…The first report on application of dedicated parallel microwave reactors for SPOS has been given by Strohmeier and Kappe (2002). In this report, they have carried out the microwave assisted synthesis of Knoevenagel products with the use of resin-bound β-ketoesters.…”

Section: Parallel Processing In Microwave Reactorsmentioning

confidence: 99%

Microwave Assisted Reactions in Organic Chemistry: A Review of Recent Advances

Jacob¹

2012

IJC

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Revolution in organic compound synthesis has been promoted by microwave assisted organic syntheses (MAOS) by which small molecules are built up into large polymers in a fraction of time. The need for different organic compound libraries for drug discovery, biomaterial development, automated library screening; proteomics etc has supported the emergence of innovative technologies for rapid combinatorial organic synthesis using MAOS synthesis. In previous reviews on this subject the focus of MAOS has been on the process of MAOS reactions rather than the importance given to the related applications. This review focuses on solid-phase synthesis, biopolymer synthesis, applications in proteomics, parallel processing in microwave reactors and automated library generation by means of sequential microwave irradiation methods. This article has discussed the different applications of Microwave assisted synthesis of organic polymeric compounds most thoroughly by focusing on aspects of speed, reproducibility and scalability. From this review it is clearly identified that independent on the type of organic material, data consistently points out to MW as a novel and powerful tool which has enable synthesis of a number of new compounds and presents the need for future research in this area.

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Rapid Parallel Synthesis of Polymer-Bound Enones Utilizing Microwave-Assisted Solid-Phase Chemistry

Cited by 85 publications

References 51 publications

Controlled Microwave Heating in Modern Organic Synthesis

Controlled Microwave Heating in Modern Organic Synthesis

Dielectric heating effects on the activity and SO2 resistance of La0.8Ce0.2MnO3 perovskite for methane oxidation

Microwave Assisted Reactions in Organic Chemistry: A Review of Recent Advances

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