Rapid postembryonic development of a cricket flight muscle

Novicki, Andrea

doi:10.1002/jez.1402500304

Cited by 10 publications

(2 citation statements)

References 19 publications

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“…These behaviors, most thoroughly studied in the lepidopterous insect Manduca sexta, are initiated and completed in 60 -70 minutes by actions of the peptide hormones preecdysis and ecdysis-triggering hormones (PETH and ETH) 1 (2,3) and eclosion hormone (EH) (4). The findings from a number of laboratories suggest that the ecdysis sequence is set in motion following peripheral release of PETH and ETH (2,3), and the behaviors are driven by multiple loci in the CNS (5)(6)(7).…”

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confidence: 99%

Signal Transduction in Eclosion Hormone-induced Secretion of Ecdysis-triggering Hormone

Kingan¹,

Cardullo

Adams³

2001

Journal of Biological Chemistry

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Inka cells of insect epitracheal glands (EGs) secrete preecdysis and ecdysis-triggering hormones (PETH and ETH) at the end of each developmental stage. Both peptides act in the central nervous system to evoke the ecdysis behavioral sequence, a stereotype behavior during which old cuticle is shed. Secretion of ETH is stimulated by a brain neuropeptide, eclosion hormone (EH). EH evokes accumulation of cGMP followed by release of ETH from Inka cells, and exogenous cGMP evokes secretion of ETH. The secretory responses to EH and cGMP are inhibited by the broad-spectrum kinase inhibitor staurosporine, and the response to EH is potentiated by the phosphatase inhibitor calyculin A. Staurosporine did not inhibit EH-evoked accumulation of cGMP. Changes in cytoplasmic Ca 2؉ in Inka cells during EH signaling were monitored via fluorescence ratioing with fura-2-loaded EGs. Cytoplasmic Ca 2؉ increases within 30 -120 s after addition of EH to EGs, and it remains elevated for at least 10 min, corresponding with the time course of secretion. Secretion is increased in dose-dependent manner by the Ca 2؉ -ATPase inhibitor thapsigargin, a treatment that does not elevate glandular cGMP above basal levels. The secretory response to EH is partially inhibited in glands loaded with EGTA, while cGMP levels are unaffected. These findings suggest that EH activates second messenger cascades leading to cGMP accumulation and Ca 2؉ mobilization and/or influx and that both pathways are required for a full secretory response. cGMP activates a staurosporine-inhibitable protein kinase. We propose that Ca 2؉ acts via a parallel cascade with a time course that is similar to that for cGMP activation of a cGMP-dependent protein kinase.Growth and differentiation of tissues during development of insects is orchestrated by polyhydroxylated steroids, the ecdysones, and their interplay with the sesquiterpene juvenile hormones, acting through nuclear receptors to direct transcription. An important outcome of this interplay is the production of cuticular exoskeleton. After new cuticle is produced at the end of each stadium, old cuticle must be shed. This shedding of old cuticle, termed ecdysis, occurs in a stereotype sequence of behaviors (1). These behaviors, most thoroughly studied in the lepidopterous insect Manduca sexta, are initiated and completed in 60 -70 minutes by actions of the peptide hormones preecdysis and ecdysis-triggering hormones (PETH and ETH) 1 (2, 3) and eclosion hormone (EH) (4). The findings from a number of laboratories suggest that the ecdysis sequence is set in motion following peripheral release of PETH and ETH (2, 3), and the behaviors are driven by multiple loci in the CNS (5-7).ETH is secreted by Inka cells of the segmentally distributed epitracheal glands (3) in response to EH (8). EH is secreted hormonally by peripheral neurohemal endings and centrally from axons, both of the brain-centered "ventromedial" neurosecretory cells (9, 10), probably in response to ETH (7,11). Together these findings suggest a model for endocrine even...

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confidence: 99%

Signal Transduction in Eclosion Hormone-induced Secretion of Ecdysis-triggering Hormone

Kingan¹,

Cardullo

Adams³

2001

Journal of Biological Chemistry

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“…Die Flugmuskulatur ist auch bei den Nymphen von Heuschrecken schwächer ausgebildet als bei der Imago(Atzinger 1952;Wiesend 1957).Analoges wurde für die Ultrastruktur der dorsalen Längsmuskeln bei Schistocerca nitens (Caelifera) beobachtet, wobei die Anzahl der Muskelfasern bereits zwei Häutungen vor dem voneinander lösen und die Muskeln wirken wieder durchscheinend. Solche degenerativen Prozesse wurden auch am Beispiel der Ultrastruktur der dorsalen Längsmuskeln bei Grillen beschrieben(Ready & Najim 1985, Novicki 1989a. Offenbar werden die Flugmuskeln bei verschiedenen Insekten erst kurz vor dem Einsatz im Adultstadium optimal gebrauchsfertig.…”

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Anatomie des Pterothorax der Phasmatodea, Mantophasmatodea und Embioptera und seine Bedeutung für die Phylogenie der Polyneoptera (Insecta)

Klug¹

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Control of growth and ultrastructural maturation of a cricket flight muscle

Novicki

1989

J. Exp. Zool.

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The metathoracic dorsal longitudinal muscle (DLM) in the cricket Teleogryllus oceanicus increased in mass and rapidly acquired interfibrillar tracheoles and an increased proportion of mitochondria around the time of the adult molt. Both neural input and juvenile hormone levels were investigated as possible factors controlling this rapid maturation. Motor axons to the muscle were cut early in the last nymphal instar, and muscle growth slowed but ultrastructural maturation continued; the percentage of muscle volume occupied by mitochondria tripled and tracheoblasts invaded the fibers in both the denervated and contralateral innervated muscles. Newly molted last instar nymphs were treated with methoprene, a juvenile hormone analog, and examined four days following the next molt. Muscle growth was slowed but not stopped. Both mitochondrial proliferation and tracheoblast formation were completely blocked by hormone treatment. This study shows that both neural input and low levels of juvenile hormone are required for muscle growth. However, ultrastructural maturation seems to depend exclusively on low levels of juvenile hormone.

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Rapid postembryonic development of a cricket flight muscle

Cited by 10 publications

References 19 publications

Signal Transduction in Eclosion Hormone-induced Secretion of Ecdysis-triggering Hormone

Signal Transduction in Eclosion Hormone-induced Secretion of Ecdysis-triggering Hormone

Anatomie des Pterothorax der Phasmatodea, Mantophasmatodea und Embioptera und seine Bedeutung für die Phylogenie der Polyneoptera (Insecta)

Control of growth and ultrastructural maturation of a cricket flight muscle

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