Rapid prototyping of high-resolution large format microfluidic device through maskless image guided in-situ photopolymerization

Abstract

Microfluidic devices have found extensive applications in mechanical, biomedical, chemical, and materials research. However, the high initial cost, low resolution, inferior feature fidelity, poor repeatability, rough surface finish, and long turn-around time of traditional prototyping methods limit their wider adoption. In this study, a strategic approach to a deterministic fabrication process based on in-situ image analysis and intermittent flow control called image-guided in-situ maskless lithography (IGIs-ML), has been proposed to overcome these challenges. By using dynamic image analysis and integrated flow control, IGIs-ML provides superior repeatability and fidelity of densely packed features across a large area and multiple devices. This general and robust approach enables the fabrication of a wide variety of microfluidic devices and resolves critical proximity effect and size limitations in rapid prototyping. The affordability and reliability of IGIs-ML make it a powerful tool for exploring the design space beyond the capabilities of traditional rapid prototyping.

Engineered current path of vertical organic phototransistors for smart optoelectronic applications

“…Fabrication of devices with the aperture size smaller than 20 μm was not reliable through photolithography. 27,45 Therefore, we fabricated our device with the aperture size of 20 μm to ensure the reliable source network patterns and the resultant uniform electrical properties. From this result, we could consider that our developed VOPT with an aperture size of 20 μm is an optimal case for application as a photomemory with a high on/off ratio.…”

Nanoparticle Assembly: From Self‐Organization to Controlled Micropatterning for Enhanced Functionalities

“…Additive manufacturing FDM, [ 229,230] SLA, [230,231] μCLIP, [ 62,232] MJP, [ 233,234] SLM, [235] 2PP [ 236,237] Chemical processing UV lithography, [ 238,239] EBL, nanoimprinting lithography, [ 240,241] soft lithography, [ 227,242] wet etching [ 243,244] Mechanical processing Micro-milling, [ 245,246] micro-grinding, [ 228] micro abrasive water jet machining, [ 247] CNC machining, [ 248,249] ultrasonic machining, [ 250] injection molding, [ 251] hot embossing, [ 251,252] replica molding, [ 253,254] casting [ 242,255] Other energy-intensive physical processing Laser writing, [ 256,257] laser ablation, [ 258] laser microcladding, [ 259] FIB, [ 53,260] EDM, [ 261,262] optical waveguide writing, [ 263] laser-induced forward transfer, [ 264] laser micro-fabrication with masks, [ 265,…”

Microphysiologically Engineered Vessel-Tumor Model to Investigate Vascular Transport Dynamics of Immune Cells

“…The microfluidic technique offers a flexible approach to engineer tumor-on-chip platforms and recreates vascular transport in vitro. − Several studies focus on the early stage of vascularization and manipulate different strategies to promote the growth of endothelial cells around the tumor by altering the microphysiological environment. − Dey et al explored the cytotoxicity induced by CAR-T in the breast tumor microenvironment based on blood vessels and dynamic flow . Similarly, Ayuso et al used a microfluidic model to simulate and study NK cell migration, cytotoxicity, and antibody-dependent cytotoxicity in complex 3D structures .…”