Rapid recovery from major depression using magnesium treatment

Eby, George A.; Eby, Karen L.

doi:10.1016/j.mehy.2006.01.047

Cited by 237 publications

(167 citation statements)

References 27 publications

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“…As a result, Changes in iron metabolism has been suggested as potential pathological markers in patients with depression [36]. It is also believed to increase the binding of dopamine and serotonin to serotonin binding proteins in the frontal cortex [37].…”

Section: Main Minerals Linked With Depressionmentioning

confidence: 99%

The Role of Micronutrient for Depressed Patients

Demelash¹

2017

J Neuropsychopharmacol Mental Health

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Majority of people are not aware of the relation between nutrition and depression. Depression is mostly resulted from an imbalance in brain chemical that can be due to more typically thought of as strictly biochemical-based or emotionally-rooted. As a result, nutrition can play a key role in the onset as well as severity and duration of depression. Several micronutrient deficiencies adversely affect the brain and hence could aggravate mental disorders. It is important that proper attention to diet, and, when indicated, appropriate supplementation with vitamin C, folic acid, niacin, thiamine, iron, zinc, magnesium , potassium and sodium and omega-3 fatty acids. As the brain chemical (neurotransmitters) are made from chemical precursors, usually from an amino acid (protein) and other micronutrients (vitamin and minerals), it is clear to understand how deficiencies of these nutrients could lead to changes in the pattern of brain chemical neurotransmitter production leading to mental illness like depression.

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Section: Main Minerals Linked With Depressionmentioning

confidence: 99%

The Role of Micronutrient for Depressed Patients

Demelash¹

2017

J Neuropsychopharmacol Mental Health

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“…Nasuprot tome, nivo magnezijuma u serumu/plazmi nije adekvatan pokazatelj prisustva depresivnog poremećaja, jer su u različitim studijama dobijeni različiti rezultati (17). Prema rezultatima dosadašnjih istraživanja, nivo magnezijuma u serumu/plazmi kod osoba koje boluju od depresije može biti povećan, snižen ili nepromenjen (13,(23)(24)(25)(26). Grupa istraživača smatra da je koncentracija magnezijuma u mozgu mnogo bolji indikator od koncentracije magnezijuma u serumu/plazmi (13).…”

Section: Povezanost Magnezijuma I Depresijeunclassified

“…Terapija je primenjivana oralno i to 125-300 mg magnezijuma uz svaki obrok i pred spavanje, uz restrikciju unosa kalcijuma i glutamata (24).…”

Section: Primena Magnezijuma Kod Depresivnih Poremećajaunclassified

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Role of magnesium in depression?

Petrović¹,

Pešić²,

Popović³

et al. 2014

Arh farmaciju

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Magnezijum ima značajnu fiziološku ulogu u humanom organizmu i neophodan je za mnoge procese, uključujući: transmembransko kretanje jona, aktivnost neurona, oslobađanje neurotransmitera, regulaciju adenilat ciklaze i vezivanje pojedinih hormona za receptore. U centralnom nervnom sistemu magnezijum blokira aktivnost NMDA receptora, a deficit magnezijuma dovodi do prekomerne aktivacije NMDA receptora, što za posledicu može imati oštećenja neurona i neurološke disfunkcije i u krajnjoj liniji, može se manifestovati razvojem velike depresije. Brojna pretklinička i klinička ispitivanja potvrđuju da magnezijum utiče na nekoliko sistema uključenih u razvoj depresije. Sa druge strane, oko 40% pacijenata pokazuje rezistenciju na tretman standardnim antidepresivima, kojima se pripisuju i brojni neprijatni neželjeni efekti. Iako je prvi pozitivan učinak magnezijuma kod pacijenata koji pate od agitirane depresije prikazan još 1921, nažalost, samo mali broj studija koje govore u prilog efikasnosti magnezijuma u tretmanu depresije je publikovan tokom proteklih decenija, uključujući jedno randomizovano kliničko ispitivanje koje je pokazalo podjednaku efikasnost magnezijuma i imipramina kod starijih depresivnih pacijenata koji boluju od dijabetesa. Iako je neophodno sprovesti veći broj kliničkih ispitivanja i proširiti ovo polje istraživanja u cilju potvrđivanja njegove efikasnosti, usled svoje bezbednosti, magnezijum bi se potencijalno mogao uvesti kao dodatni tretman u lečenju depresije rezistentne na terapiju.

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“…[7] The studies showed an association of depression status and severity with decreased serum vitamin D. [8,9] Dietary deficiencies of magnesium, coupled with excess calcium and stress may cause many cases of other related symptoms including hallucinations, agitation, anxiety, irritability, confusion, sleeplessness, headache and delirium. [10] The result of a study has suggested that alterations in essential trace elements manganese, copper and iron may play a role in the pathogenesis of schizophrenia. [11] Vitamin B12, folate and ferritin deficiency may also present with psychiatric symptoms.…”

mentioning

confidence: 99%

Determination of vitamin B12, folate, and ferritin levels of inpatients in a psychiatry clinic: A one-year retrospective study

Örüm¹

2018

FNG & Bilim Tıp Dergisi

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Objectives:This study aims to compare the vitamin B12, folate, and ferritin levels of inpatients in a psychiatry clinic. Materials and methods:The study included 286 inpatients (178 males, 108 females; mean age 35.4±12.9 years; range, 15 to 76 years) treated in Adiyaman University Training and Research Hospital psychiatry clinic between 01 January 2017 and 31 December 2017. Patients' diagnoses and vitamin B12, folate, and ferritin levels were examined retrospectively. Results:The most common diagnoses were schizophrenia (23.4%), bipolar affective disorder (23.1%), and major depressive disorder (11.5%). While there was no significant difference in vitamin B12 levels according to sex (p=0.850), folate level was significantly lower in males (p=0.001) and ferritin level was significantly lower in females (p=0.001). No difference was detected in the levels of vitamin B12, folate and ferritin in the comparison between diagnoses. Conclusion: Deficiency in vitamin B12, folate, and ferritin levels may cause psychiatric symptoms. Due to the high number of patients with low vitamin B12 levels in our study, more attention may be paid to vitamin B12 replacement. Ferritin deficiency in females and folate deficiency in males are noteworthy. Further research are needed to identify more specific and detailed algorithms related to vitamin B12, folate, and ferritin to support the findings of this study and optimize the care given to patients suffering from psychiatric syndromes. Bulgular: En sık görülen tanılar şizofreni (%23.4), bipolar affektif bozukluk (%23.1) ve majör depresif bozukluk (%11.5) idi. Cinsiyete göre B12 vitamini düzeylerinde anlamlı farklılık yokken (p=0.850) erkeklerde folat düzeyi (p=0.001) ve kadınlarda ferritin düzeyi (p=0.001) anlamlı olarak düşük idi. Tanılar arasındaki karşılaştırmada; B12 vitamini, folat ve ferritin düzeyleri arasında farklılık tespit edilmedi. Sonuç: B12 vitamini, folat ve ferritin düzeylerinde eksiklik psikiyatrik semptomlara neden olabilir. Çalışmamızda B12 vitamini düzeyi düşük olan hasta sayısının fazla olmasına bağlı olarak B12 vitamini replasmanında daha dikkatli olunabilir. Kadınlardaki ferritin eksikliği ve erkeklerdeki folat eksikliği dikkat çekicidir. Bu çalışmanın bulgularını desteklemek ve psikiyatrik sendromu olan hastalara verilen bakımın optimize edilmesi için B12 vitamini, folat ve ferritine ilişkin daha spesifik ve ayrıntılı algoritmaları belirlemek amacıyla ileri araştırmalar gerekmektedir.Anahtar sözcükler: Ferritin; folik asit; yatan hastalar; psikiyatri; retrospektif çalışma; B12 vitamini.

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Rapid recovery from major depression using magnesium treatment

Cited by 237 publications

References 27 publications

The Role of Micronutrient for Depressed Patients

The Role of Micronutrient for Depressed Patients

Role of magnesium in depression?

Determination of vitamin B12, folate, and ferritin levels of inpatients in a psychiatry clinic: A one-year retrospective study

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