Rapid recovery in a child with febrile ulceronecrotic Mucha‐Habermann disease following intravenous immunoglobulin administration

Abstract

Febrile ulceronecrotic Mucha‐Habermann disease (FUMHD), a lymphocyte‐mediated inflammatory skin disorder, is considered a severe variant of pityriasis lichenoides et varioliformis acuta that can lead to a fatal outcome if not managed in a timely fashion. Children with FUMHD can have systemic complications involving various organs. The scarcity of reported cases and the absence of well‐designed studies or randomized clinical trials to evaluate different therapeutic modalities pose a major challenge in treating this potentially life‐threatening disorder. We report a five‐year‐old child with FUMHD and seizures treated unsuccessfully with a combination of systemic steroids, methotrexate, dapsone, and oral erythromycin, who improved rapidly and achieved disease control with just a single infusion of low‐dose intravenous immunoglobulin.