Rapid Relief of Treatment Resistant Depression by Facilitated Ketamine Infusion: A Preliminary Report

Best, Steven

doi:10.1007/bf03379605

Cited by 4 publications

(2 citation statements)

References 37 publications

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“…A further paper by Best (2014b) is a retrospective study involving 28 cases of TRD in patients with either unipolar or bipolar affective disorders. Twenty of those patients underwent a pretreatment phase lasting anywhere from 3 days to 2 weeks.…”

Section: Combined Rtms and Ketamine Treatmentmentioning

confidence: 99%

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Transcranial magnetic stimulation and ketamine: implications for combined treatment in depression

Dębowska,

Więdłocha,

Dębowska

et al. 2023

Front. Neurosci.

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Drug-resistant mental disorders, particularly treatment-resistant depression, pose a significant medical and social problem. To address this challenge, modern psychiatry is constantly exploring the use of novel treatment methods, including biological treatments, such as transcranial magnetic stimulation (TMS), and novel rapid-acting antidepressants, such as ketamine. While both TMS and ketamine demonstrate high effectiveness in reducing the severity of depressive symptoms, some patients still do not achieve the desired improvement. Recent literature suggests that combining these two methods may yield even stronger and longer-lasting results. This review aims to consolidate knowledge in this area and elucidate the potential mechanisms of action underlying the increased efficacy of combined treatment, which would provide a foundation for the development and optimization of future treatment protocols.

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Section: Combined Rtms and Ketamine Treatmentmentioning

confidence: 99%

“…ACC, anterior cingulate cortex; cTBS, continuous theta-burst stimulation; dlPFC, dorsolateral prefrontal cortex; Hz, hertz; min, minutes; iTBS, intermittent theta-burst stimulation; IV, intravenous; OCD, obsessive-compulsive disorder; rTMS, repetitive transcranial magnetic stimulation; MT, motor threshold; *, indicates a follow-up study toBest (2014b).…”

mentioning

confidence: 99%

Transcranial magnetic stimulation and ketamine: implications for combined treatment in depression

Dębowska,

Więdłocha,

Dębowska

et al. 2023

Front. Neurosci.

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Synergistic use of deep TMS therapy with IV ketamine infusions for major depressive disorder: a pilot study

Shanok,

Muzac,

Brown

et al. 2024

Psychopharmacology

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Combination therapy with transcranial magnetic stimulation and ketamine for treatment-resistant depression: A long-term retrospective review of clinical use

Best

Pavel

Haustrup³

2019

Heliyon

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Background Both transcranial magnetic stimulation (TMS) and infused ketamine are recognized treatments for patients suffering from major depressive disorder (MDD). A novel therapy named combination TMS with ketamine (CTK) is introduced. This retrospective review examined the safety and clinical benefits of CTK in patients suffering from treatment-resistant depression (TRD) during the routine practice of psychiatry in a private clinic. Methods TRD patients (N = 28) received a coincident application of high-output TMS (30 minutes) with biomarker-determined ketamine infusions (20 minutes). Frequency of treatment was dependent on patient responsiveness (10–30 sessions). Clinical global impression (CGI) data was collected pre- and post-treatment and then two years later. Results The mean reduction in CGI severity for the patient group following CTK was 4.46 ± 0.54 at a 99% confidence interval and was deemed statistically significant using a paired t-test (α = 0.01, t = 22.81 p < 0.0001). This reduction was sustained for two years following treatment completion and this remission was deemed statistically significant by a second paired t-test (α = 0.01, t = 27.36, p < 0.0001). Limitations Retrospective review of a limited number of patients undergoing CTK in a clinical practice. Conclusions This clinical review indicated that CTK is an effective, long-term therapy (after two years) and can be used for TRD patients. The coincident administration of ketamine allowed for higher TMS intensities than otherwise would be tolerated by patients. Further studies for optimization of CTK are warranted.

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Rapid Relief of Treatment Resistant Depression by Facilitated Ketamine Infusion: A Preliminary Report

Cited by 4 publications

References 37 publications

Transcranial magnetic stimulation and ketamine: implications for combined treatment in depression

Transcranial magnetic stimulation and ketamine: implications for combined treatment in depression

Synergistic use of deep TMS therapy with IV ketamine infusions for major depressive disorder: a pilot study

Combination therapy with transcranial magnetic stimulation and ketamine for treatment-resistant depression: A long-term retrospective review of clinical use

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