Rapid Resolution of Vulvar Crohn's Disease With Ustekinumab

Stoleru, Gianna; Robbins, Gordon; Papadimitriou, John C.; Wong, Uni

doi:10.14309/crj.0000000000000452

Cited by 6 publications

(4 citation statements)

References 6 publications

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“…Furthermore, longterm metronidazole is associated with peripheral neuropathy, which can limit its continued use [13]. With the advent of biological agents, several studies have reported excellent outcomes with infliximab and azathioprine [3,4,[6][7][8][9][10][11][12][13][14][15] among others like ustekinumab, which have shown rapid resolution of symptoms similar to the outcome in our patient [15].…”

Section: Discussionmentioning

confidence: 65%

Metastatic Vulval Crohn’s Disease With Good Outcome on Ustekinumab

Lim¹,

Singh²

2021

Cureus

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Vulval Crohn's disease is a rare manifestation of Crohn's disease. Although it is usually caused by a fistulating process, it may be a result of a metastatic disease process as well, the exact mechanisms of which are not well understood yet. Vulval Crohn's disease may occur before the onset of bowel symptoms and may continue to be active while bowel symptoms are quiescent. Coupled with the fact that most vulval Crohn's lesions are similar to other disease processes, it can prove to be a diagnostic challenge. Due to its rarity, no guidelines for treatment exist; however, most reports agree that when symptoms are not controlled with antibiotics and topical steroids, immunosuppressive medications such as oral steroids and biological agents are the way forward. Although surgery may be an option, data suggest that its use is scarce. We report the case of a 47-year-old Caucasian woman with bilateral metastatic vulval Crohn's disease from a district hospital in the United Kingdom who responded well to ustekinumab. This is one of the first few cases reporting good clinical outcomes with the agent.

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Section: Discussionmentioning

confidence: 65%

Metastatic Vulval Crohn’s Disease With Good Outcome on Ustekinumab

Lim¹,

Singh²

2021

Cureus

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“…(2020) и Y. Lim, M. Singh (2021) в своих публикациях делятся впечатлением о скорости развития положительного эффекта и быстром исчезновении симптомов генитального поражения МетБК после начала терапии устекинумабом [6,27].…”

Section: Discussionunclassified

Use of ustekinumab in vulvovaginal lesions associated with Crohn's disease (clinical case)

Segal

Lozovskaya

Mardamshina

et al. 2023

Medicinskij alfavit

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Involvement of the vulva and vagina in Crohn's disease (CD) is rare and underdiagnosed because many other more likely inflammatory processes in this area are considered. Late diagnosis and ineffectiveness of treatment lead to the development of complications, a decrease in the quality of life of women. A clinical case of a lesion of the vulvovaginal zone in a young patient, regarded as extraintestinal (metastatic) CD, is presented. The presented clinical case shows the effectiveness of treatment with ustekinumab for poorly controlled CD and extraintestinal manifestations of this disease, in particular, the effectiveness of treatment of chronic vulvovaginitis has been demonstrated.

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“…Less commonly, genital involvement occurs, as in vulvar CD (2). Vulvar CD has been described in case reports and case series, but larger studies including descriptions of possible therapies are limited (2)(3)(4)(5)(6)(7)(8)(9). Vulvar involvement may not parallel intestinal involvement.…”

Section: Introductionmentioning

confidence: 99%

“…Reports have suggested that antibiotics, corticosteroids, and biologic agents such as anti-tumor necrosis factor (TNF) may be effective treatments (2,(4)(5)(6)10). Recently, antiinterleukin 12/23 therapies have been used to manage vulvar CD (7,8). Because of the rarity of the condition and lack of large reported series, we sought to describe our institutional experience with vulvar CD and outline clinical features, treatments, and outcomes.…”

Section: Introductionmentioning

confidence: 99%

Vulvar Crohn's Disease: Clinical Features and Outcomes

et al. 2021

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INTRODUCTION: Vulvar involvement is a rare complication of Crohn's disease (CD). The optimal treatment of vulvar CD is unknown. METHODS: We conducted a 25-year retrospective cohort study of vulvar CD from 3 referral centers. Clinical features and outcomes were studied. RESULTS: Fifty patients were identified. The most common vulvar symptoms were pain (74%), edema (60%), ulcerations (46%), nodules (36%), and abscess (34%). Medical management leading to symptomatic improvement varied, and 5 patients ultimately required surgery. DISCUSSION: Vulvar CD manifests with a broad spectrum of symptoms. Aggressive medical management was frequently effective, although surgery was required in 10% of cases.

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Rapid Resolution of Vulvar Crohn's Disease With Ustekinumab

Cited by 6 publications

References 6 publications

Metastatic Vulval Crohn’s Disease With Good Outcome on Ustekinumab

Metastatic Vulval Crohn’s Disease With Good Outcome on Ustekinumab

Use of ustekinumab in vulvovaginal lesions associated with Crohn's disease (clinical case)

Vulvar Crohn's Disease: Clinical Features and Outcomes

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