Rapid response of a poly(acrylamide) hydrogel having a semi‐interpenetrating polymer network structure

Miyata, Takashi; Asami, Noriko; Okawa, Kaori; Uragami, Tadashi

doi:10.1002/pat.818

Cited by 19 publications

(14 citation statements)

References 26 publications

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“…H ydrogels have recently been of increasing interest in various applications. 1,2 The gels are useful for drug delivery systems, separation operations in biotechnology, processing of agricultural products, sensors, and actuators. [3][4][5][6][7][8][9] The volume phase transitions of hydrogels are introduced by a continuous change in various conditions of network such as temperature, pH, electrical field, radiation of UV or visible light, solvent composition, salt concentration, and type of surfactants.…”

Section: Introductionmentioning

confidence: 99%

3‐Mercaptopropionic Acid–Ce(IV) Redox Couple for Preparing Cross‐Linked Gels with Moderate Swelling Ratios

Özeroğlu¹,

Özduğancι²

2012

Adv Polym Technol

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3-Mercaptopropionic acid-Ce(IV) redox couple has been demonstrated to be useful for cross-linking polymerization of acrylamide (AAm) with N,N -methylene bis(acrylamide) (MBAA). Effects of the cross-linker ratio, acid concentration, and Ce(IV) molar ratios on swelling behavior of the resulting hydrogels have been studied. These experiments show that increasing cross-linker content has greatly reduced the equilibrium swelling ratios as expected. Interestingly, the increase in the Ce(IV) concentration (n Ce(IV) = n MPA ) has resulted in a decrease in the swelling ratio. Because the thiol group in 3-mercaptosuccinic acid acts as a cross-linking agent, more cross-linking occurs with an increase in the Ce(IV) concentration and Ce(III) forming in the cross-linking polymerization reaction of AAm with MBAA may provide the formation of intermolecular complexes between amide groups in polymer chains; the swelling equilibrium ratio and swelling rate decrease with an increase in their concentrations in the cross-linking polymerization reaction of AAm with MBAA. Kinetics and equilibrium swelling values have been discussed in terms of reaction parameters. C 2012 Wiley Periodicals, Inc. Adv Polym Techn 32: E241-E248, 2013; View this article online at wileyonlinelibrary.com.

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Section: Introductionmentioning

confidence: 99%

3‐Mercaptopropionic Acid–Ce(IV) Redox Couple for Preparing Cross‐Linked Gels with Moderate Swelling Ratios

Özeroğlu¹,

Özduğancι²

2012

Adv Polym Technol

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“…103 After linear PAAm was synthesized by polymerization of AAm, a PAAm hydrogel with semi-IPN structure was prepared by copolymerization of AAm and MBAA as a crosslinker in the presence of linear PAAm. The shrinkage response of the PAAm semi-IPN hydrogel in acetone/water mixtures was compared with a PAAm hydrogel consisting of only a cross-linked network without linear polymers ( Figure 13).…”

Section: Network Design Of Hydrogelsmentioning

confidence: 99%

Preparation of smart soft materials using molecular complexes

Miyata

2010

Polym J

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This article provides a short overview of our research regarding the preparation of smart soft materials using molecular complexes that reversibly associate and dissociate in response to environmental changes. Stimuli-responsive hydrogels that show swelling/shrinking in response to pH and temperature were prepared by copolymerization of a monomer bearing a phosphate group and other various monomers. Hydrogels with phosphate groups were useful tools for the construction of self-regulated drug delivery systems. Furthermore, we proposed a strategy for the preparation of biomolecule-responsive hydrogels that use reversible crosslinks in the networks of biomolecular complexes. Based on this strategy, we have prepared two types of biomolecule-responsive hydrogel that undergo changes in volume in response to target biomolecules. This was accomplished using biomolecular complexes such as antigen-antibody complexes and saccharide-lectin complexes and both a biomolecule-crosslinked hydrogel and a biomolecule-imprinted hydrogel have been synthesized with this approach. Biomolecule-crosslinked hydrogels, such as glucose-and antigen-responsive hydrogels, swelled in the presence of a target biomolecule due to the dissociation of biomolecular complexes that act as reversible crosslinks. On the other hand, biomolecule-imprinted hydrogels, such as tumor marker glycoprotein-responsive hydrogels, shrank in response to a target biomolecule due to the formation of a complex between ligands (lectin and antibody) and the target biomolecule. Thus, biomolecule-responsive hydrogels have many potential applications as smart biomaterials in biomedical fields. Although most smart soft materials prepared using molecular complexes still require further research, they are likely to become important materials in the future.

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“…Hydrogels derived from PAM also have many useful chemical and physical properties and have been investigated for applications as smart polymers. [8] These applications include immobilization of biocatalysts, [9] drug delivery systems, [10][11][12] bioseparators, [13] and protein adsorption. [14] In this paper, we describe a novel method to prepare PAM hydrogels with a gradient crosslinking density via photoinitiation of a thick system (about 10 cm).…”

Section: Introductionmentioning

confidence: 99%

Fabrication of poly(acrylamide) hydrogels with gradient crosslinking degree via photoinitiation of thick polymer system

Yang

2011

Polymers for Advanced Techs

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In this paper, we report on the synthesis of poly(acrylamide) (PAM) hydrogels by photoinitiation with a thick system. The hydrogels exhibited gradient crosslinking density along the light path. Thermogravimetric analyses (TGA) proved the same effects. We investigated some factors affecting the swelling ratio of the hydrogels such as crosslinking agent concentration, photoinitiator concentration, and monomer concentration. The as‐prepared hydrogels might have some potential applications in drug delivery systems and other function materials. Copyright © 2009 John Wiley & Sons, Ltd.

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Rapid response of a poly(acrylamide) hydrogel having a semi‐interpenetrating polymer network structure

Cited by 19 publications

References 26 publications

3‐Mercaptopropionic Acid–Ce(IV) Redox Couple for Preparing Cross‐Linked Gels with Moderate Swelling Ratios

3‐Mercaptopropionic Acid–Ce(IV) Redox Couple for Preparing Cross‐Linked Gels with Moderate Swelling Ratios

Preparation of smart soft materials using molecular complexes

Fabrication of poly(acrylamide) hydrogels with gradient crosslinking degree via photoinitiation of thick polymer system

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