Rapid restoration of bone mass after surgical management of hyperthyroidism: A prospective case control study in Southern India

Karunakaran, Poongkodi; Maharajan, Chandrasekaran; Mohamed, Kamaludeen N.; Rachamadugu, Suresh V.

doi:10.1016/j.surg.2015.10.002

Cited by 14 publications

(4 citation statements)

References 22 publications

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“…Hyperthyroidism represents a type of autoimmune disease (1)(2)(3). Previous studies have revealed that bone mineral density (BMD) is frequently decreased in patients, which potentially leads to osteoporosis (4,5). In general, BMD is associated with the metabolism of vitamin D in the body.…”

Section: Introductionmentioning

confidence: 99%

Changes in bone mineral density, 25‑hydroxyvitamin D3 and inflammatory factors in patients with hyperthyroidism

Zhou

Wang²,

Xin

et al. 2021

Exp Ther Med

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The present study aimed to evaluate changes in bone mineral density, 25-hydroxyvitamin D 3 [25-(OH)D 3 ] and inflammatory factors in patients with hyperthyroidism, in order to determine the correlations with the pathogenesis of hyperthyroidism. A total of 55 patients with hyperthyroidism (observation group) and 53 healthy patients (control group) enrolled at Weifang People's Hospital from March 2017 to February 2018 were randomly enrolled. The thyroid function, bone mineral density, 25-(OH)D 3 and inflammatory factors were measured and compared between the two groups. The measurement data are presented as mean ± standard deviation (SD), and Student t-test was performed for the comparison between two groups. Chi-square test was used for enumeration data regarding sex. Pearson correlation analysis was performed for two-variable analysis on L1, 25-(OH)D 3 , interleukin (IL)-2, IL-6 with FT3, respectively. In regards to the results, no difference in sex, age and body mass index (BMI) between the two groups were found but the thyroid function was markedly enhanced in the observation group compared to the control group. Bone mineral density index and 25-(OH)D 3 in the observation group were significantly lower than those in the control group (P<0.05). There were significant differences in the inflammatory factors between the two groups (P<0.05). The L1, 25-(OH)D 3 and IL-2 levels were significantly negatively correlated with thyroid function index and free triiodothyronine (FT3) while a statistically positive correlation was found between IL-6 and FT3 (P<0.05). In conclusion, abnormal levels of bone mineral density, 25-(OH)D 3 and inflammatory factors are observed in patients with hyperthyroidism, and there are correlations between L1, 25-(OH)D 3 , IL-2, IL-6 and FT3 in the pathogenesis of hyperthyroidism, which provides new insight for the diagnosis of hyperthyroidism.

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Section: Introductionmentioning

confidence: 99%

Changes in bone mineral density, 25‑hydroxyvitamin D3 and inflammatory factors in patients with hyperthyroidism

Zhou

Wang²,

Xin

et al. 2021

Exp Ther Med

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“…13,17 Furthermore, the author has shown in the previously published reports that the radical technique of TT was associated with higher rates of PH in thyrotoxic subjects and facilitates rapid recovery of bone mineral density. 33,34 Moreover, 25OHD levels were not different in subjects exhibiting and not exhibiting PH among thyrotoxic subjects. Recently, Manzini et al had reported that decreased preoperative vitamin D levels did not predict PH, which is in keeping with our observation.…”

Section: Discussionmentioning

confidence: 84%

The utility of serum 25-hydroxyvitamin D in predicting post-thyroidectomy hypocalcemia in thyrotoxic subjects: a single-center cohort study

Karunakaran

Abraham

2020

Int Surg J

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Background: The role of preoperative vitamin D deficiency as a predictor of post-thyroidectomy hypocalcemia in thyrotoxic subjects is controversially reported. This prospective cohort study determined the utility of serum 25-hydroxyvitamin D (25OHD) levels in predicting transient hypocalcemia in thyrotoxic and euthyroid patients undergoing total thyroidectomy (TT).Methods: Subjects with new-onset hyperthyroidism (n=97; age=median (Inter-Quartile Range); 38 (18) years; M:F=25:72) and age; sex-matched euthyroid cohorts (n=231; age=37 (18) years; M:F=40:191) undergoing TT were evaluated for serum corrected-calcium, intact parathormone and 25OHD levels at baseline, 48-hour and 6-months post-TT, p value <0.05 was considered significant.Results: The incidence of transient hypocalcemia in thyrotoxic subjects was 58.8% (57/97) versus 22.5% (52/179) in euthyroid cohorts. In receiver operating characteristic analysis predicting transient hypocalcemia for the test-variable preoperative 25OHD, the area under curve (AUC) among euthyroid subjects was 0.725 (95% CI: 0.641-0.809; p<0.001) with a threshold of 17.6 ng/mL with sensitivity and specificity of 65.4% and 64.2% respectively. In thyrotoxic subjects, the AUC was 0.573 (95% CI; 0.452-0.694; p=0.222) with poorer predictability and was less than that of euthyroid subjects.Conclusions: Preoperative 25OHD below 17.6 ng/ml was reliable in predicting transient postoperative hypocalcemia in euthyroid subjects though with a limited sensitivity and specificity but unreliable in thyrotoxic subjects undergoing TT.

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“…Several studies have evaluated BTMs in patients with overt hyperthyroidism [36][37][38][39][40][41][42][43]. In one study that compared patients with hyperthyroidism and age-matched controls, it was found that both bone formation and resorption markers were increased in the former, and the changes in resorption markers were more prominent than those in formation markers [36].…”

Section: Evaluation Of Bone Health Using Assessment Tools Other Than Dxamentioning

confidence: 99%

“…Some BTMs, especially resorption markers, are correlated with serum free triiodothyronine (T3) levels [ 36 , 39 ]. Recovery of BTMs can be achieved after treating hyperthyroidism [ 36 , 39 , 41 ], and in such cases, bone resorption markers show a more rapid decrease than formation markers [ 39 ]. However, neither absolute levels of BTMs nor changes in BTMs after treatment of hyperthyroidism seem to reflect bone status better than DXA.…”

Section: Hyperthyroidismmentioning

confidence: 99%

Evaluation and Management of Bone Health in Patients with Thyroid Diseases: A Position Statement of the Korean Thyroid Association

Hong¹,

Kang

2023

Endocrinol Metab

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Thyroid hormones play an important physiological role in maintaining adult bone structure and strength. Consequently, thyroid dysfunction is related to skeletal outcomes. Overt hyperthyroidism is an established cause of high bone turnover with accelerated bone loss, leading to osteoporosis and increased fracture risk. Hyperthyroidism induced by thyroid-stimulating hormone-suppressive therapy in patients with differentiated thyroid cancer is a cause of secondary osteoporosis. In contrast, there is a lack of evidence on the negative impact of hypothyroidism on bone health. Considering the clinical updates on the importance of bone health in thyroid dysfunction, the Task Force from the Clinical Practice Guidelines Development Committee of the Korean Thyroid Association recently developed a position statement on the evaluation and management of bone health of patients with thyroid diseases, particularly focused on endogenous hyperthyroidism and thyroid-stimulating hormone-suppressive therapy-associated hyperthyroidism in patients with differentiated thyroid cancer. Herein, we review the Korean Thyroid Association’s position statement on the evaluation and management of bone health associated with thyroid diseases.

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Rapid restoration of bone mass after surgical management of hyperthyroidism: A prospective case control study in Southern India

Cited by 14 publications

References 22 publications

Changes in bone mineral density, 25‑hydroxyvitamin D3 and inflammatory factors in patients with hyperthyroidism

Changes in bone mineral density, 25‑hydroxyvitamin D3 and inflammatory factors in patients with hyperthyroidism

The utility of serum 25-hydroxyvitamin D in predicting post-thyroidectomy hypocalcemia in thyrotoxic subjects: a single-center cohort study

Evaluation and Management of Bone Health in Patients with Thyroid Diseases: A Position Statement of the Korean Thyroid Association

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