Rapid reversal of circadian blood pressure rhythm in shift workers

Sundberg, Stig; Kohvakka, Antti; Gordin, A.

doi:10.1097/00004872-198805000-00009

Cited by 127 publications

(62 citation statements)

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“…Some studies, carried out on dogs, reported low mean BP throughout the night to early morning and high BP from early morning and throughout the day (Broten et al, 1988). Other authors (Mishina et al, 1999) have monitored the 24-h BP in dogs using telemetry and observed changes almost identical to those reported in humans (Baumgart, 1991;Mancia et al, 1993;Sundberg et al, 1988) with the highest values during periods of activity and the lowest during sleep.…”

Section: Introductionsupporting

confidence: 62%

Chronobiologic blood pressure assessment: Maturation of the daily rhythm in newborn foals

et al. 2008

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Circadian rhythmicity of physiological processes in animals has been described for some variables. In order to investigate the daily rhythmicity of blood pressure, seven foals (Equus caballus) were used for 40 days after birth. Measurements of blood pressure were done by means of an oscillometric apparatus (Argus TM-7, Schiller, Barr Switzerland) with the foals in a standing position and the cuff placed around the tail. Blood pressure was recorded twice a day, 1 hour before dawn and 1 hour before dusk for the first 10 days of life, every 2 days from the 11 th to the 32 nd day, on the 36 th and on the 40 th day. Two-way repeated measures analysis of variance (ANOVA) were used to determine statistically significant differences between the mean values recorded at dawn and dusk during the study. Analysis of variance showed a significant effect of time (p<0.0001), during the first 40 days of life. This study confirms a strong correlation between age and blood pressure in horse and the absence of blood pressure maturation in foals 40 days old. The results on the maturation of the daily rhythm of blood pressure in foals is a contribution to the study of the development of circadian rhythms in mammals. These results are also useful for the chronophysiological assessment of blood pressure in the horse.

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Section: Introductionsupporting

confidence: 62%

Chronobiologic blood pressure assessment: Maturation of the daily rhythm in newborn foals

et al. 2008

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“…This means that the circadian clock within the heart of rodents is dyssynchronous with the environment between 3 and 7 days following reversal of the L/D cycle. In humans, shift workers show an essentially complete re-entrainment of blood pressure rhythms within the first 24 h of the shift rotation (43,44). Assuming that the rate of re-entrainment for the circadian clock within the human heart mirrors that of rodents, one would hypothesize that the repetitive reversal of the L/D by shift workers would prevent synchrony between the circadian clock within the heart and its environment.…”

Section: Discussionmentioning

confidence: 99%

The Circadian Clock within the Cardiomyocyte Is Essential for Responsiveness of the Heart to Fatty Acids

Durgan

Trexler

Egbejimi

et al. 2006

Journal of Biological Chemistry

147

139

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Cells/organs must respond both rapidly and appropriately to increased fatty acid availability; failure to do so is associated with the development of skeletal muscle and hepatic insulin resistance, pancreatic ␤-cell dysfunction, and myocardial contractile dysfunction. Here we tested the hypothesis that the intrinsic circadian clock within the cardiomyocytes of the heart allows rapid and appropriate adaptation of this organ to fatty acids by investigating the following: 1) whether circadian rhythms in fatty acid responsiveness persist in isolated adult rat cardiomyocytes, and 2) whether manipulation of the circadian clock within the heart, either through light/dark (L/D) cycle or genetic disruptions, impairs responsiveness of the heart to fasting in vivo. We report that both the intramyocellular circadian clock and diurnal variations in fatty acid responsiveness observed in the intact rat heart in vivo persist in adult rat cardiomyocytes. Reversal of the 12-h/12-h L/D cycle was associated with a re-entrainment of the circadian clock within the rat heart, which required 5-8 days for completion. Fasting rats resulted in the induction of fatty acid-responsive genes, an effect that was dramatically attenuated 2 days after L/D cycle reversal. Similarly, a targeted disruption of the circadian clock within the heart, through overexpression of a dominant negative CLOCK mutant, severely attenuated induction of myocardial fatty acid-responsive genes during fasting. These studies expose a causal relationship between the circadian clock within the cardiomyocyte with responsiveness of the heart to fatty acids and myocardial triglyceride metabolism.

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“…This is thought to be due to the nature that humans are diurnal, sleeping during the night and active throughout the day, whereas rats are nocturnal, active during periods of darkness and sleeping during periods of exposure to light [1,7,9,12,[15][16][17]. It has been recognized in humans that shift-workers who work at night show the high BP values at night [1,23]. This indicates that they are influenced not only by the circadian rhythm, but also by the body's activities due to the external environment.…”

Section: Discussionmentioning

confidence: 99%

Diurnal Variations of Blood Pressure in Dogs

Mishina

Watanabe

Matsuoka

et al. 1999

The Journal of Veterinary Medical Science

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ABSTRACT. Using the telemetry system, we measured the blood pressure (BP) invasively in seven adult mongrels while unanesthetized and unbound. Post-operative BP after implanting the telemetry BP transmitter showed temporarily high values due to the invasive nature of the surgery. It was, however, observed that BP gradually decreased thereafter, and showed settled trends from the eighth day postoperatively. When we took the average of the systolic, mean and diastolic BP at hourly intervals for each of the dogs once their BP had settled, a twin peak diurnal variation (at 8:00 and 19:00) was observed. Moreover, significantly high values (p<0.05) were identified in active state compared with when sleeping or at rest. The 24 hr BP measured by the telemetry system in seven normal dogs resulted in the following values: systolic 123.4 ± 7.9 mmHg, mean 91.1 ± 5.6 mmHg, and diastolic 74.5 ± 4.9 mmHg.-KEY WORDS: blood pressure, canine, diurnal variation.J. Vet. Med. Sci. 61(6): 643-647, 1999 were exposed under anesthesia, and BP measuring transmitter (model TL10M2-D70) catheter was indwelled. The transmitter body was implanted into a subcutaneous pocket that had created first. After examining the BP by use of transmitter, the digital signal was received by a receiver (RLA2000), and was sent in turn to a consolidation matrix (BCM-100), and a universal adapter (UA10). Finally, the digital signal was converted to an analogue signal by the universal adapter, and output to an analytical computer system (Softron ECG Processor SBP4.8:Softron Co., Tokyo, Japan) (Fig. 1). Further, the systolic, mean and diastolic BP were calculated from the continuous BP readings input for approximately 10 sec at a time at 5 min intervals, and the average were taken to be the systolic, mean and diastolic values for each hour. These measurements were taken continuously for 24 hr, and the following examinations were conducted. Examination of the BP changes after implanting transmitter:We examined the effect of the invasive surgery on BP after the transmitter had been implanted for 14 days post-operatively. For the BP examination, we used the total and average values (24 hr BP) taken every 24 hr using the systolic, mean and diastolic pressure measured at 5 min intervals.Examination into the diurnal BP variations: We examined the diurnal BP variations in normal dogs for a period of seven days after at least one month had passed since the transmitter were implanted. First of all, the systolic, mean and diastolic BP were measured at 5 min intervals and totaled in hourly blocks and examined using their average values. In order to observe the relationship between BP and activity, a comparison was made among the sleeping period (1:00-6:00), the resting period (12:00-17:00), awaking but comparatively settled period, and the periods of intense activity (7:00-9:00 and 18:00-20:00). In addition, comparisons were also made with both the 24 hr BP and For measuring blood pressure (BP) in awake dogs, there are either invasive method by arterial puncture or nonin...

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Rapid reversal of circadian blood pressure rhythm in shift workers

Cited by 127 publications

References 0 publications

Chronobiologic blood pressure assessment: Maturation of the daily rhythm in newborn foals

Chronobiologic blood pressure assessment: Maturation of the daily rhythm in newborn foals

The Circadian Clock within the Cardiomyocyte Is Essential for Responsiveness of the Heart to Fatty Acids

Diurnal Variations of Blood Pressure in Dogs

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