Rapid rise in incidence of Irish paediatric inflammatory bowel disease

Hope, Ben; Shahdadpuri, R; Dunne, Cara; Broderick, Annemarie; Grant, Tim; Hamzawi, M.; O'Driscoll, K; Quinn, Sean M.; Hussey, Séamus; Bourke, Billy

doi:10.1136/archdischild-2011-300651

Cited by 69 publications

(66 citation statements)

References 28 publications

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“…CD was more common than UC in children in the USA, United Kingdom, Scotland, Wales and Sweden. [5,8,[16][17][18] Our results were similar to those found in the Italian pediatric-IBD database and adult-IBD database. [4] The mean age of the patients at the time of diagnosis with IBD was 11.6 years which was younger than that in other studies.…”

Section: Discussionsupporting

confidence: 94%

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Inflammatory bowel disease in Turkish children

Çakır¹,

Ünal²,

Dinler

et al. 2015

World J Pediatr

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Section: Discussionsupporting

confidence: 94%

“…[4,5,[7][8][9][10] Most studies [4,5,[7][8][9][10] revealed that the incidence of IBD is increasing in childhood and the increment is more prominent in CD. The studies also found obesity related IBD, secondary IBD due to immune deficiencies or autoimmune diseases, and a high rate of colectomy in patients with UC.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory bowel disease in Turkish children

Çakır¹,

Ünal²,

Dinler

et al. 2015

World J Pediatr

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“…Nevertheless, most contemporary pediatric studies from Europe and North America 10,14,31-33 report a pediatric phenotype characterized by significantly more widespread intestinal inflammation than observed in our cohort (Table 4). It is possible that the inconsistent observations even between neighboring countries 10,19,31,32 could reflect real differences in childhood-onset CD phenotype. However, the shared genetic and environmental conditions within Scandinavia and the British Isles suggest that some of the reported differences might rather be explained by differences in classification.…”

Section: Discussionmentioning

confidence: 89%

“…The hypothesis that childhood-onset IBD patients will face a more severe disease course than adults has been questioned recently as some studies have presented less severe outcomes than previously reported. 12,13,19 The introduction of modern immunosuppressive drugs has fueled hopes that early intensive pharmacological treatment might have the potential to modify the IBD disease course. 20 Following this expectation, the treatment paradigm has shifted from focusing on symptomatic control to involve subclinical intestinal inflammation also.…”

mentioning

confidence: 99%

Presentation and Progression of Childhood-Onset Inflammatory Bowel Disease in Northern Stockholm County

Malmborg

Grahnquist

Ideström

et al. 2015

Inflammatory Bowel Diseases

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Patients with childhood-onset IBD were characterized by extensive colitis that was relatively stable over time and associated with a relatively low risk of complications and abdominal surgery. Our findings confirm the more extensive disease location in pediatric IBD but did not identify the proposed dynamic and aggressive nature of the childhood-onset phenotype. The association of nonmucosal healing with a complicated disease course suggests that endoscopy should guide treatment intensity in childhood-onset CD.

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“…With regards to the increase in examinations for the pediatric patients the analysis of demographic data provides important information [11][12][13] . While in 1990 the youngest patient who underwent enteroclysis was 16 years old, in the years 2004-2010 already 4-year-old children were examined.…”

Section: Discussionmentioning

confidence: 99%

Enteroclysis: Current clinical value

Maataoui

Vogl²,

Jacobi³

et al. 2013

WJR

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AIM:To retrospectively analyze changes in clinical indication, referring medical specialty and detected pathology for small bowel double-contrast examinations. METHODS:Two hundred and forty-one (n = 143 females; n = 98 males; 01. 01.1990-31.12.1990) and 384 (n = 225 females; n = 159 males; 01.01.2004-31.12.2010) patients underwent enteroclysis, respectively. All examinations were performed in standardized double-contrast technique. After placement of a nasojejunal probe distal to the ligament of Treitz, radiopaque contrast media followed by X-ray negative distending contrast media were administered. Following this standardized projections in all four abdominal quadrants were acquired. Depending on the detected pathology further documentation was carried out by focused imaging. Examination protocols were reviewed and compared concerning requesting unit, indication and final report. RESULTS:Two hundred and forty-one examinations in 1990 faced an average of 55 examinations per year from 2004-2010. There was an increase of examinations for gastroenterological (33.6% to 64.6%) and pediatric (0.4% to 7.8%) indications while internal (29.0% to 6.0% for inpatients and from 16.6% to 9.1% for outpatients) and surgical (12.4% to 7.3%) referrals significantly decreased. "Follow-up of Crohn's disease" (33.1%) and "bleeding/tumor search" (15.1%) represented the most frequent clinical indications. A total of 34% (1990) and 53.4% (2004-2010) examinations yielded pathologic findings. In the period 01.01.2004 -31.12.2010 the largest proportion of pathological findings was found in patients with diagnosed Crohn's disease (73.5%), followed by patients with abdominal pain (67.6% with history of surgery and 52.6% without history of surgery), chronic diarrhea (41.7%), suspected Crohn's disease (39.5%) and search for gastrointestinal bleeding source/tumor (19.1%). The most common pathologies diagnosed by enteroclysis were "changes in Crohn's disease" (25.0%) and "adhesions /strictures" (12.2%).CONCLUSION: "Crohn's disease" represents the main indication for enteroclysis. The relative increase of pathologic findings reflects today's well directed use of enteroclysis.

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Rapid rise in incidence of Irish paediatric inflammatory bowel disease

Cited by 69 publications

References 28 publications

Inflammatory bowel disease in Turkish children

Inflammatory bowel disease in Turkish children

Presentation and Progression of Childhood-Onset Inflammatory Bowel Disease in Northern Stockholm County

Enteroclysis: Current clinical value

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