2012
DOI: 10.1093/cid/cis625
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Rapid Salvage Treatment With Virus-Specific T Cells for Therapy-Resistant Disease

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Cited by 116 publications
(96 citation statements)
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References 43 publications
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“…Multimer selection technique was first exploited by Cobbold [102] with a direct selection technique by using a panel of CMV IE1 and pp65 tetramers to select specific T cells from HSCT donors. Later, Uhlin and colleagues [101] …”
Section: Direct Ex Vivo Selection Techniquesmentioning
confidence: 97%
See 1 more Smart Citation
“…Multimer selection technique was first exploited by Cobbold [102] with a direct selection technique by using a panel of CMV IE1 and pp65 tetramers to select specific T cells from HSCT donors. Later, Uhlin and colleagues [101] …”
Section: Direct Ex Vivo Selection Techniquesmentioning
confidence: 97%
“…Techniques for direct selection of VSTCs include the use of peptide pools derived from viral antigens to expand T cells with multiple antigen specificities [97], the selection of VSTCs based upon the secretion of interferon-gamma (IFN-gamma) [98,99] or the binding to class I HLA-multimers [100] or immunomagnetic beads [101]. The multimer selection method requires HLA-specific elements for every viral epitope and is actually restricted to CD8+ T-cells, while the IFN-gamma secretion technique is based upon a HLAunrestricted selection of CD4+ and CD8+.…”
Section: Direct Ex Vivo Selection Techniquesmentioning
confidence: 99%
“…16,22,23 Our group has tried separation of peptide-specific T cells with the help of magnetic beads and MHC multimers. 17,18 Even though this has shown promising results, none of these strategies is yet part of standard clinical practice.In this retrospective analysis we analyzed possible risk factors associated with the development of PTLD after SCT at our center. The earlier part of the cohort of patients was previously included in the studies by Sundin et al and Omar et al 1,24 We found several factors that were independently associated with an increased risk of PTLD.…”
mentioning
confidence: 99%
“…In addition, six patients showed a decrease in viral titers within 2 weeks of CTl infusion. 33 With respect to tetramer multimers, in vitro and in vivo studies show conflicting results when analyzing the functional status of virus-specific CTLs after tetramer selection. On the other hand, there is no in vitro study addressing whether pentamer staining and selection could induce anergy in specific T cells.…”
Section: Role Of the Multimer In The Regulation Of Function Of Antigementioning
confidence: 99%
“…However, the previously mentioned study shows functional EBV-specific CTLs that are able to remove the EBV-driven lymphoma. 33 As described above, the influence of tetramer and pentamer staining over the function of the T cell remains an important unresolved issue. This is a problem that potentially could limit substantially the clinical applicability of the multimer technology.…”
Section: Role Of the Multimer In The Regulation Of Function Of Antigementioning
confidence: 99%