Rapid screening and determination of 4‐chloroamphetamine in saliva by paper spray‐mass spectrometry and capillary electrophoresis‐mass spectrometry

Jhang, Chih Sheng; Lee, Hsun; He, Yi Zhou; Liu, Ju Tsung; Lin, Cheng Huang

doi:10.1002/elps.201200270

Cited by 28 publications

(14 citation statements)

References 32 publications

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“…Although the methodology and specific aims of papers differ, they have a common theme in showing that PS-MS can detect and quantify therapeutic drugs [12], [1], [8], [18], [6], [11], [17], [4], [19], [15], [20], [21] and drugs of abuse [9], [5], [10] (including designer drugs [22], [23]). In many cases, these drugs and metabolites are detected at clinically or physiologically relevant concentrations with good quantitative performance directly from biofluid.…”

Section: A Xenobioticsmentioning

confidence: 99%

Analysis of Biofluids by Paper Spray MS: Advances and Challenges

2016

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Paper spray mass spectrometry (MS) is part of a cohort of ambient ionization or direct analysis methods that seek to analyze complex samples without prior sample preparation. Extraction and electrospray ionization occur directly from the paper substrate upon which a dried matrix spot is stored. Paper spray MS is capable of detecting drugs directly from dried blood, plasma, and urine spots at the low ng/mL to pg/mL levels without sample preparation. No front end separation is performed, so tandem mass spectrometry (MS/MS) or high resolution MS is required. Here, we discuss paper spray methodology, give a comprehensive literature review of the use of paper spray MS for bioanalysis, discuss technological advancements and variations on this technique, and discuss some of its limitations. _________________________________________________________________________________ AbstractPaper spray mass spectrometry (MS) is part of a cohort of ambient ionization or direct analysis methods that seek to analyze complex samples without prior sample preparation. Extraction and electrospray ionization occur directly from the paper substrate upon which a dried matrix spot is stored. Paper spray MS is capable of detecting drugs directly from dried blood, plasma, and urine spots at the low ng/mL to pg/mL levels without sample preparation. No front end separation is performed, so tandem mass spectrometry (MS/MS) or high resolution MS is required. Here, we discuss paper spray methodology, give a comprehensive literature review of the use of paper spray MS for bioanalysis, discuss technological advancements and variations on this technique, and discuss some of its limitations.

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Section: A Xenobioticsmentioning

confidence: 99%

Analysis of Biofluids by Paper Spray MS: Advances and Challenges

2016

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“…Paper spray is a member of this growing cohort of ambient ionization or direct analysis methods that was conceived because of the growing interest in storing and transporting blood samples as dried spots. One of the major applications of paper spray mass spectrometry has been screening and quantitative analysis of drugs and other small molecules from biofluids such as blood, urine, and plasma [3][4][5][6][7][8][9][10][11][12][13][14].…”

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confidence: 99%

Ionization Suppression and Recovery in Direct Biofluid Analysis Using Paper Spray Mass Spectrometry

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Zhang

et al. 2016

J. Am. Soc. Mass Spectrom.

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Abstract. Paper spray mass spectrometry is a method for the direct analysis of biofluid samples in which extraction of analytes from dried biofluid spots and electrospray ionization occur from the paper on which the dried sample is stored. We examined matrix effects in the analysis of small molecule drugs from urine, plasma, and whole blood. The general method was to spike stable isotope labeled analogs of each analyte into the spray solvent, while the analyte itself was in the dried biofluid. Intensity of the labeled analog is proportional to ionization efficiency, whereas the ratio of the analyte intensity to the labeled analog in the spray solvent is proportional to recovery. Ion suppression and recovery were found to be compound-and matrix-dependent. Highest levels of ion suppression were obtained for poor ionizers (e.g., analytes lacking basic aliphatic amine groups) in urine and approached -90%. Ion suppression was much lower or even absent for good ionizers (analytes with aliphatic amines) in dried blood spots. Recovery was generally highest in urine and lowest in blood. We also examined the effect of two experimental parameters on ion suppression and recovery: the spray solvent and the sample position (how far away from the paper tip the dried sample was spotted). Finally, the change in ion suppression and analyte elution as a function of time was examined by carrying out a paper spray analysis of dried plasma spots for 5 min by continually replenishing the spray solvent.

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“…e mass spectrometer (Finnigan LCQ Classic LC/MS/MS) used in this study was the same instrument that was used in our previous study. 11,[20][21][22] e mass signal was recorded under the full scan mode (m/z 100-400). An Xcalibur data system was used for data collection, and the data were converted into an ASCII text le.…”

Section: Methodsmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9][10][11] Furthermore, since the development of ambient ionization mass spectrometry, socalled paper spray-mass spectrometry (PS-MS) has opened new insights in the eld of mass spectrometric analysis and, since its debut on 2010, it has now become a quite popular and important method for use in mass spectrometry. 12) us far, PS-MS has been applied successfully in many areas of research, including food science, 13) the analysis of protein complexes, 14,15) bio uid samples, 16,17) the online chemical monitoring of cell cultures, 18) rapid discrimination of bacteria, 19) and drugs of abuse in whole blood or saliva, [20][21][22] and even in an ambient organic analysis. 23) Some novel alternate techniques based on PS-MS have also been reported, including a 3D-printed paper spray ionization cartridge/ continuous solvent supply and the rapid detection of cocaine residues by paper spray ionization coupled with ion mobility spectrometry.…”

Section: Introductionmentioning

confidence: 99%

Development and Application of a Brush-Spray Derived from a Calligraphy-Brush-Style Synthetic Hair Pen for Use in ESI/MS

et al. 2017

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e development of a novel type of a sampling/ionization kit for use in electrospray ionization/mass spectrometry is reported. Using a small calligraphy-brush-style synthetic hair pen (nylon-brush), and analogous to paper-spray mass spectrometry, the analytes can be collected, elution/desorption and then ionized from the surface of the nylon-brush. e body of the kit was produced by means of a commercial 3D-printer, in which ABS (acrylonitrile butadiene styrene) was used as the starting material. Meanwhile, a small nylonbrush was embedded inside a 3D-printed plastic cell, in which a solvent was supplied to rinse the brush by means of capillary action. e size and weight of the kit were 1 g and 4 cm, respectively. e kit is disposable and it has various functions, including non-invasive sampling, sample-evaporation and ionization. As a result, when a type of pesticide was selected as the test sample (dimethoate; C 5 H 12 NO 3 PS 2 ), the limit of detection was determined to be 0.1 µg/mL. Collecting the pesticide from a leaf-surface (lettuce) was also successful. e process for fabricating the nylon-brush kit and the optimized experimental conditions are reported herein.

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Rapid screening and determination of 4‐chloroamphetamine in saliva by paper spray‐mass spectrometry and capillary electrophoresis‐mass spectrometry

Cited by 28 publications

References 32 publications

Analysis of Biofluids by Paper Spray MS: Advances and Challenges

Analysis of Biofluids by Paper Spray MS: Advances and Challenges

Ionization Suppression and Recovery in Direct Biofluid Analysis Using Paper Spray Mass Spectrometry

Development and Application of a Brush-Spray Derived from a Calligraphy-Brush-Style Synthetic Hair Pen for Use in ESI/MS

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