Rapid screening and identification of illicit drugs by IR absorption spectroscopy and gas chromatography

Mengali, Sandro; Liberatore, Nicola; Luciani, Domenico; Viola, Roberto; Cardinali, G.C.; Elmi, I.; Poggi, Antonella; Zampolli, S.; Biavardi, Elisa; Dalcanale, Enrico; Bonadio, Federica; Delémont, Olivier; Esseiva, Pierre; Romolo, Francesco Saverio

doi:10.1117/12.2003903

Cited by 15 publications

(7 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Photoacoustic spectroscopy is not the only potential laser-based infrared detection method for GC. As an alternative approach, hollow optical waveguides, ,, including hollow-core photonic crystal fibers, offer an efficient way of minimizing the sample volume. Additionally, miniaturization of optical cavities could make cavity-enhanced absorption spectroscopic techniques a tempting detection method for GC.…”

Section: Discussionmentioning

confidence: 99%

“…The optical waveguide is similar to a GC capillary and increases the absorption path length tenfold compared to lightpipes, while maintaining sample volumes in the microliter range. In a more recent work, Mengali et al used the same principle but employed a widely tunable EC-QCL to allow better spectral identification . With the absorption path length in the order of meters, the reported hollow waveguide spectrometers leave room for improvement in terms of detection sensitivity compared to the state-of-the-art LAS detectors.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Broadband Laser-Based Infrared Detector for Gas Chromatography

et al. 2020

View full text Add to dashboard Cite

Cantilever-enhanced photoacoustic spectroscopy coupled with gas chromatography is used to quantitatively analyze a mixture of alcohols in a quasi-online manner. A full identification and quantification of all analytes are achieved based on their spectral fingerprints using a widely tunable continuous-wave laser as a light source. This can be done even in the case of interfering column/septum bleed or simultaneously eluted peaks. The combination of photoacoustic spectroscopy and gas chromatography offers a viable solution for compact and portable instruments in applications that require straightforward analyses with no consumables.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Broadband Laser-Based Infrared Detector for Gas Chromatography

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In this paper we are presenting an artificial intelligence application that was developped in order to operate a new portable laser GC-IRAS spectrometer, which was developped within the DIRAC EU project [7,8]. The application was designed to provide: a) a fast automatic screening for amphetamines and for ephedrines; b) a way to predict the pharmacological activity of the detected amphetamine (stimulant or hallucinogenic); c) a user-friendly human-machine interface, making the instrument easy to use for law enforcement officers without needing a strong background in analytical chemistry.…”

Section: Introductionmentioning

confidence: 99%

Pattern recognition analysis of the class identity recognition efficiency of a portable laser infrared sensor detecting amphetamines and their main precursors

Praisler

Ciochina

2019

Ann_UGAL_Math_Phys_Mec

View full text Add to dashboard Cite

We are presenting a pattern recognition analysis assessing the class identity recognition efficiency of a portable laser infrared sensor detecting controlled phenethylamines, i.e. the stimulant and hallucinogenic amphetamines, as well as ephedrines, which are their main precursors. The training set consists of laser infrared spectra of the later compounds and of negatives, which are randomly selected non-amphetamines. The spectra have been recorded in the spectral domain 1405 -1150 cm -1 , preprocessed with a w TE 2 Fisher discriminating function, and then subjected to Principal Component Analysis (PCA). The PCA scores have been used in order to build several pattern recognition systems designed to recognize the class identity of the targeted compounds, i.e. Cluster Analysis and Naive Bayesian Classifier. The detection efficiency obtained for these two systems is presented and discussed in detail.

show abstract

“…Such a portable hollow fiber IRAS spectrometer screening for amphetamines and their precursors was recently developed under the FP7-SEC-2009-242309 DIRAC project [4,5]. For miniaturization purposes, as opposed to bench-top infrared spectrometers, the infrared radiation source of this prototype is a Quantum Cascade Laser (QCL).…”

Section: Introductionmentioning

confidence: 99%

Artificial intelligence application built for ATS detection with a new portable hollow fiber IRAS spectrometer

Praisler

Ciochina

Stoica

2014

2014 18th International Conference on System Theory, Control and Computing (ICSTCC)

View full text Add to dashboard Cite

We are presenting signal preprocessing and analysis methods that were successfully applied for improving the performance of a new portable hollow fiber infrared absorption spectrometer built for screening for amphetamine-type stimulants (ATS) in law enforcement operations. The challenge in developing the automated class identity assignment system was to model the similarity of the spectra of amphetamines and, in the same time, to discriminate them from non-amphetamines based only on the absorptions recorded in a very narrow spectral window (1550 -1330 cm -1 ), as the radiation source of the portable spectrometer is a Quantum Cascade Laser. The presented signal selective amplifier has significantly enhanced the efficiency of the developed artificial intelligence application screening for the targeted drugs of abuse. The main variables contributing to the formation of distinct clusters (associated to stimulant and to hallucinogenic amphetamines) has been performed by Principal Component Analysis. The classification efficiency has been evaluated based on Hierarchical Cluster Analysis, i.e. agglomerative clustering.

show abstract

Rapid screening and identification of illicit drugs by IR absorption spectroscopy and gas chromatography

Cited by 15 publications

References 10 publications

Broadband Laser-Based Infrared Detector for Gas Chromatography

Broadband Laser-Based Infrared Detector for Gas Chromatography

Pattern recognition analysis of the class identity recognition efficiency of a portable laser infrared sensor detecting amphetamines and their main precursors

Artificial intelligence application built for ATS detection with a new portable hollow fiber IRAS spectrometer

Contact Info

Product

Resources

About