Rapid Screening of Mupirocin Skin Permeation Modification by Micronized and Nanonized Alaptide

Jampílek, Josef; Opatřilová, Radka

doi:10.5599/admet.2.1.26

Cited by 3 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, all multi-drug resistant strains were susceptible to mupirocin, and zones of growth inhibition (> 19 mm at the 5 μg disc) were in agreement with Creagh and Lucey (33). Mupirocin (mixture of several pseudomonic acids) is an antibiotic originally isolated from Pseudomonas fluorescens and is structurally unrelated to any other antibiotic (34). Pseudomonic acid is capable of binding to the isoleucyl t-RNA synthetase in Staphylococcus sp., resulting in a total inhibition of their protein synthesis (35).…”

Section: Discussionsupporting

confidence: 88%

See 1 more Smart Citation

Participation and Drug Resistance of Coagulase-Positive Staphylococci Isolated From Cases of Pyoderma and Otitis Externa in Dogs

Szewczuk

Zych²,

Sablik

2020

SVR

View full text Add to dashboard Cite

Staphylococcus pseudintermedius is considered as a major pathogen in dogs, typically involved in skin and ear infections. Other staphylococci, as well as ß-hemolytic streptococci, Pseudomonas aeruginosa or yeast-like fungi of the genus Malassezia also play an important role in inflammation. Because of this diversity, an appropriate choice of antimicrobial agent(-s) can be difficult. A total of 474 tests were performed (including 255 pyoderma and 219 otitis externa cases). In the case of pyoderma, 82.4% of skin lesions were caused by stap hylococci. Co-infections with ß-hemolytic streptococci (17.3 %), Malassezia sp. (15.7 %) and P. aeruginosa (4.3 %) were also recorded. For external ear infections, the share of staphylococci in inflammation was lower (44.8 %) than that of Malassezia sp. (58 %). Relatively frequent co-infections with ß-hemolytic streptococci (18.8 %) and P. aeruginosa (7.8 %) were also noted. A total of 308 susceptibility tests for coagulase-positive staphylococci were performed (210 and 98 for skin and otitis externa, respectively). In ≥ 86 % of cases, amoxicillin potentiated with clavulanic acid, cephalexin and fluoroquinolones effectively inhibited the growth of all bacteria in vitro. A total of 25 isolates (24 S. pseudintermedius and one S. aureus) were considered as methicillin-resistant. The mecA gene was identified in 100 % of those strains but only 44 % of the isolates additionally carried the blaZ gene. All mecA-positive staphylococci were multidrugresistant, mainly to all ß-lactams, fluoroquinolones, linkozamides, macrolides as well as sulfonamides but always susceptible to mupirocin. Overall, multidrug-resistance varied between 6 % (otitis externa) and 9 % (inflamed skin) and may become a significant problem in the future.

show abstract

Section: Discussionsupporting

confidence: 88%

“…Unfortunately, after intravenous or oral administration, mupirocin is rapidly metabolized to monic acid, which has no antibacterial activity. Therefore, only topical treatment of bacterial skin infections (as ointments or creams) or nano-carriers remain available (34).…”

Section: Discussionmentioning

confidence: 99%

Participation and Drug Resistance of Coagulase-Positive Staphylococci Isolated From Cases of Pyoderma and Otitis Externa in Dogs

Szewczuk

Zych²,

Sablik

2020

SVR

View full text Add to dashboard Cite

show abstract

Alaptide as Transdermal Permeation Modifier

Jampílek

Dohnal

2015

Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement

View full text Add to dashboard Cite

From past to present, exploring the applications of mupirocin ointment: A comprehensive review

Pal,

Nayak,

Kura

et al. 2024

IJCED

View full text Add to dashboard Cite

Mupirocin (MUP), a potent antibacterial agent, has been a cornerstone of topical antimicrobial therapy for several decades. As an older, yet widely used antibiotic, MUP has exhibited efficacy against various bacterial strains, making it a versatile tool in the management of a range of infections. The review synthesizes available literature to highlight the evolution of MUP, from its initial discovery to its current status as a go-to topical antibiotic. In the era of rising antibiotic resistance, MUP is positioned as a valuable therapeutic option due to its broad-spectrum activity against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). Emphasis is placed on its distinctive role in different infections, enhanced efficacy with different additives, and newer drug delivery strategies.In addition to its classical applications in impetigo and other superficial skin infections, this review delves into emerging indications and novel uses of MUP, potentially expanding its clinical utility. The exploration of combination therapies, alternative formulations, and ongoing research endeavors will contribute to a forward-looking perspective on the role of MUP in future antimicrobial strategies.

show abstract

Rapid Screening of Mupirocin Skin Permeation Modification by Micronized and Nanonized Alaptide

Cited by 3 publications

References 14 publications

Participation and Drug Resistance of Coagulase-Positive Staphylococci Isolated From Cases of Pyoderma and Otitis Externa in Dogs

Participation and Drug Resistance of Coagulase-Positive Staphylococci Isolated From Cases of Pyoderma and Otitis Externa in Dogs

Alaptide as Transdermal Permeation Modifier

From past to present, exploring the applications of mupirocin ointment: A comprehensive review

Contact Info

Product

Resources

About