Rapid screening of pharmaceutical products for elemental impurities by a high-resolution portable energy dispersive X-ray fluorescence spectrometer using an efficient fundamental parameter method

Abstract

In this study, a rapid screening method of elemental impurities in pharmaceutical products has been established by the portable energy dispersive X-ray fluorescence (EDXRF) spectra combined with the efficient fundamental...

Simultaneous detection of trace As, Hg, Tl, and Pb in biological tissues using monochromatic excitation X-ray fluorescence spectrometry

“…The estimated concentration values are iteratively adjusted based on a ratio between the calculated and measured intensity until all elements achieve convergence. 21 Based on this calibration process, an algorithm model for detecting heavy metals in biological tissues was developed.…”

Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages

“…It was found that Pb did not significantly vary across the bone types compared to the mid-tibia except for the ilium, with the authors recommending the tibia as the preferred location for comparison studies. Zhu et al 161 described the application of a high-resolution portable EDXRF spectrometer for pharmaceutical analysis, considering the requirements of International Conference on Harmonisation (ICH) Q3D and US Pharmacopoeia 233 standards. The proposed method covered 22 elemental impurities (Ag, As, Au, Cd, Co, Cr, Cu, Hg, Ir, Mo, Ni, Os, Pb, Pd, Pt, Rh, Ru, Sb, Se, Sn, Tl and V) and was demonstrated to meet the requirements for accuracy, precision, LOD, LOQ and linearity under these standards, based on a 10 g maximum daily intake.…”

Atomic spectrometry update: review of advances in the analysis of metals, chemicals and materials

“…A paper by Zhu et al described the use of a portable EDXRF instrument for the determination of 22 elemental impurities in the oral solid dose drugs Contezolid and Aztreonam . 76 Also used during the study was cellulose onto which elemental standards were injected. The analytes were split into three groups: those requiring low energy (Co, Cr, Ni and V), medium energy (As, Au, Cu, Hg, Ir, Os, Pb, Pd, Rh, Ru, Se and Tl) and high energy (Ag, Cd, Mo, Pt, Sb and Sn).…”