“…Particle–particle interaction in a singular system, that is, homoaggregation, is primarily influenced by diffusion potential at the colloidal scale and particle collision radius. − Experimental and theoretical studies are well established on the fundamentals of homoaggregation theory and mechanisms for a variation of their surface properties, background solution chemistry, and other physicochemical attributes. ,,− In a more complex natural or biological setting, aggregation occurs in presence of other dissimilar particles – in terms of chemical composition, electrical charge, size, or shape – and is termed as heteroaggregation. − Heteroaggregation of ENMs is identified as an important phenomenon not only in biological and natural systems but also in engineered processes; for example, separation technology, coating processes, food and biotechnological processes, , ceramic industries, and composites or core–shell materials . Nanomaterial interaction in such heterosystems is also likely to be influenced by physicochemical properties and background chemical conditions.…”