2004
DOI: 10.1002/jcla.20027
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Rapid, simple, and reliable method for the diagnosis of CAPD peritonitis using the new MMP‐9 test kit

Abstract: The objective of the present study was to evaluate the sensitivity and efficiency of the matrix metalloproteinase-9 (MMP-9) test kit for the diagnosis of bacterial peritonitis in patients undergoing peritoneal dialysis (PD). Peritoneal effluents were collected from seven continuous ambulatory PD (CAPD) patients with peritonitis, four patients with suspected peritonitis, 30 maintenance PD patients without infection, and seven patients at initiation of PD. The MMP-9 test kit was used to analyze 112 peritoneal ef… Show more

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Cited by 21 publications
(18 citation statements)
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“…• There is not enough evidence for recommending the use of novel techniques [such as leukocyte esterase, broad-spectrum polymerase chain reaction (PCR), quantitative bacterial DNA PCR] for the diagnosis of peritonitis (58)(59)(60)(61)(62)(63)(64).…”
Section: Other Novel Diagnostic Techniquesmentioning
confidence: 99%
See 1 more Smart Citation
“…• There is not enough evidence for recommending the use of novel techniques [such as leukocyte esterase, broad-spectrum polymerase chain reaction (PCR), quantitative bacterial DNA PCR] for the diagnosis of peritonitis (58)(59)(60)(61)(62)(63)(64).…”
Section: Other Novel Diagnostic Techniquesmentioning
confidence: 99%
“…The latter technique may also help to identify those patients likely to relapse despite apparent clinical improvement with standard antibiotic therapy (62). Another study suggests that the matrix metalloproteinase-9 test kit may be a reliable method for early diagnosis of PD peritonitis (63). The role of rapid detection of the causative pathogen of peritonitis using in situ hybridization has also been explored (64).…”
Section: Other Novel Diagnostic Techniquesmentioning
confidence: 99%
“…MMP-9 is hardly detected in the peritoneal effluent of patients without infectious peritonitis. However, in patients with infectious peritonitis, MMP-9 levels in the peritoneal effluent increased markedly with a slight increase in MMP-2 levels [25,35,36]. These findings suggest that peritoneal injury that may lead to EPS can be clearly distinguished from infectious peritonitis by analyzing MMP-2 and MMP-9 levels in the peritoneal effluent (Figure 2).…”
Section: Mmps As Peritoneal Injury Markers In Clinical Diagnosismentioning
confidence: 94%
“…An MMP-9 test kit has been developed to diagnose infectious peritonitis. This kit consists of an anti-MMP-9 antibody conjugated to a colloidal dye designed to detect MMP-9 in a nitrocellulose membrane dipstick assay based on immunochromatography [36,39]. The diagnosis can be successfully completed within 10 min.…”
Section: Mmps As Peritoneal Injury Markers In Clinical Diagnosismentioning
confidence: 99%
“…In 2004, my colleagues Ro et al [110] developed a rapid, simple, and reliable method for the diagnosis of PD peritonitis using the new MMP-9 test kit. Peritoneal inflammation continues even after the cessation of peritoneal dialysate stimulation.…”
Section: Peritoneal Dialysis: Animal Model and Patientsmentioning
confidence: 99%