2005
DOI: 10.1016/j.yjmcc.2004.11.015
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Rapid stimulation causes electrical remodeling in cultured atrial myocytes

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Cited by 99 publications
(97 citation statements)
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“…For example, the proportions of L-and T-type calcium currents are variable from passage to passage, or even in the same preparation. 27 All of the cells have a relatively larger I CaT density compared with that in human atrial myocytes.…”
Section: Limitationsmentioning
confidence: 93%
“…For example, the proportions of L-and T-type calcium currents are variable from passage to passage, or even in the same preparation. 27 All of the cells have a relatively larger I CaT density compared with that in human atrial myocytes.…”
Section: Limitationsmentioning
confidence: 93%
“…9,11,20 HSP expression was increased by preexposure to GGA or heat shock (Figure 1). Cell tachypacing reduced CaT and contractile function, effects prevented by HSP induction (Figure 2A and 2B).…”
Section: Effect Of Hsp Induction On Tachypaced Hl-1 Myocytesmentioning
confidence: 95%
“…Previous in vitro models of atrial tachycardia remodeling have included rapidly paced HL-1 cells derived from a mouse atrial tumor cell line, 38 and paced human atrial tissue slices. 25 The HL-1 cell model displays important features of atrial remodeling but is limited by a low expression rate of I CaL (Ͻ20% of cells display prominent I CaL ) and K ϩ channel remodeling (unchanged I to , increased I Kr ) 38 that differs from the established pattern of in vivo atrial tachycardia remodeling (reduced I to , unchanged I Kr ).…”
Section: Circulation Research October 10 2008mentioning
confidence: 99%
“…25 The HL-1 cell model displays important features of atrial remodeling but is limited by a low expression rate of I CaL (Ͻ20% of cells display prominent I CaL ) and K ϩ channel remodeling (unchanged I to , increased I Kr ) 38 that differs from the established pattern of in vivo atrial tachycardia remodeling (reduced I to , unchanged I Kr ). 4,20,37 The human tachypaced atrial slice model reproduces some biochemical features seen in AF patients, but its electrophysiological properties have not been established, and atrial tissue superfusion is known to cause important functional alterations and viability problems.…”
Section: Circulation Research October 10 2008mentioning
confidence: 99%