Rapid surface-to-volume ratio and tortuosity measurement using Difftrain

Davies, C.J.; Griffith, Jonathan D.; Sederman, Andrew J.; Gladden, Lynn F.; Johns, Michael L.

doi:10.1016/j.jmr.2007.04.006

Cited by 18 publications

(11 citation statements)

References 20 publications

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“…Both 1808 pulses have the same phase cycle. Because of Figure 3 The modified Difftrain pulse sequence (13). Here the angle of the a pulse can vary in each echo loop, as well as the observation time increment T inc,n .…”

Section: Phase Cyclesmentioning

confidence: 99%

“…Alternatively, line-broadening techniques (40) can be used to allow the FID to be acquired within the time T inc ; the addition of the diffusion dimension can compensate for the loss of spectral resolution in some samples. Nevertheless, in this context, Difftrain has only been cited for use as a materials characterization technique (13,23).…”

Section: Applicationsmentioning

confidence: 99%

“…Davies et al have compared the Difftrain and APGSTE pulse sequences in the microstructural characterization of non-porous bead packs (13). The bead packs were formed from 100 mm glass ballotini with the void space saturated with deionized water.…”

Section: Microstructure Characterizationmentioning

confidence: 99%

“…This agreement is confirmed in Table 2 where the values of S/V, 'pore size' (assuming spherical pores), and tortuosity are presented for the bead pack. Theoretical values were obtained from the known average bead diameter and estimated packing fraction (13). If only the surface-to-volume ratio or the tortuosity were required, the experimental time could be reduced further (in this example to 1.66 min) using Difftrain to probe one of the two regimes shown in Fig.…”

Section: Microstructure Characterizationmentioning

confidence: 99%

“…Difftrain was proposed originally as a single-shot method for diffusion ordered spectroscopy (DOSY) measurements (11), although it has not as yet, to the best of our knowledge, been utilized by the NMR spectroscopy community. However, it has been employed in recent years for rapid materials analysis including droplet sizing (12) and microstructural characterization (13).…”

Section: Introductionmentioning

confidence: 99%

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Rapid measurements of diffusion using PFG: Developments and applications of the Difftrain pulse sequence

Mitchell

Johns

2009

Concepts Magnetic Resonance

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Pulsed-field gradient (PFG) nuclear magnetic resonance (NMR) is one of the few experimental techniques that can determine directly mean square molecular displacements, allowing self-diffusion coefficient of liquids to be derived. PFG measurements are used commonly for diffusion, flow, and microstructure characterization. However, these conventional PFG experiments are often time consuming, requiring the gradient strength or observation time to be incremented independently. Here we discuss how the rapid Difftrain pulse sequence has proved invaluable in the study of time sensitive systems by allowing multiple observation times to be probed in a single scan. Difftrain has been applied successfully to the study of emulsions, surfactant solutions, bead packs, and permeable rock cores. We discuss various implementations of the Difftrain pulse sequence, suggest suitable phase cycles, and review the applications to date.

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Section: Phase Cyclesmentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

Section: Microstructure Characterizationmentioning

confidence: 99%

Section: Microstructure Characterizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Rapid measurements of diffusion using PFG: Developments and applications of the Difftrain pulse sequence

Mitchell

Johns

2009

Concepts Magnetic Resonance

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Magnetic Resonance Studies of Drop‐Freezing Processes

Johns

Wilson

Hindmarsh

2008

Magnetic Resonance Microscopy

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Single-Sided Nuclear Magnetic Resonance (NMR) for the Analysis of Skin Thickness and Collagen Structure in Scarred and Healthy Skin

et al. 2023

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Monitoring of skin scar thickness and structural properties is desirable when assessing the efficacy of the healing process. In this work, we report the use of single-sided, low-field nuclear magnetic resonance (NMR) for the analysis of the thickness and collagen structure of healthy and scarred skin. Acquisition of T2 relaxation profiles was proven to provide quantification of porcine skin thickness as accurate as standard histological techniques. Subsequent analysis of human participants highlighted the utility of this technique for identifying different types of scar and in identifying differences between the thickness of moderate hypertrophic scars and healthy skin. Using bead packings as a model system, determination of the surface-to-volume (S/V) ratio and tortuosity (k) was successfully measured on the single-sided apparatus based on time-resolved diffusion analysis. Application of this method to human skin was able to detect regional differences in collagen structures, consistent with qualitative expectations. It was also able to differentiate between healthy and scarred skin tissue. Preliminary results indicated that scarred tissue exhibited decreased S/V ratios and tortuosities, which is coherent with the formation of less-aligned collagen within scar tissue and indicated the potential for this technique to differentiate scar types. This novel application of single-sided low-field NMR has the potential to be deployed in clinical settings for the differentiation of scar types and for the assessment and monitoring of skin scarring and healing.

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Rapid surface-to-volume ratio and tortuosity measurement using Difftrain

Cited by 18 publications

References 20 publications

Rapid measurements of diffusion using PFG: Developments and applications of the Difftrain pulse sequence

Rapid measurements of diffusion using PFG: Developments and applications of the Difftrain pulse sequence

Magnetic Resonance Studies of Drop‐Freezing Processes

Single-Sided Nuclear Magnetic Resonance (NMR) for the Analysis of Skin Thickness and Collagen Structure in Scarred and Healthy Skin

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