Rapid symptomatic and structural improvement of a retinal astrocytic hamartoma in response to anti-VEGF therapy: A case report

Unilateral Exudative Retinal Lesion in a Previously Healthy Female Teenager

“…If TSC is suspected, the primary concern must be initiating the systemic workup with neuroimaging (choice B), as the central nervous system manifestations of TSC can be life threatening. Secondarily, treatment for the ophthalmic complications of the disease can be considered, such as with anti–vascular endothelial growth factor (anti-VEGF) medications for secondary exudation (choice A) . Retinal hamartomas are not typically associated with a hypercoagulable state or cardiac concerns (choices C and D).…”

Retinal astrocytic hamartoma complicated by branch retinal vein occlusion in a patient with tuberous sclerosis complex

“…Previous studies have shown that astrocytic hamartomas, especially in patients with TSC, may be intrinsically associated with VEGF signaling for their structure and exudative properties independent of their ability to promote neovascularization. 8 , 25 , 26 Some case reports exhibit clinical improvement in response to anti -VEGF therapy without requiring any evidence of pre-retinal or choroidal neovascularization. 26 , 27 , 28 As vein occlusions can cause VEGF overproduction, avoiding to do proper management may cause tumor growth and secondary mentioned complications.…”

“… 8 , 25 , 26 Some case reports exhibit clinical improvement in response to anti -VEGF therapy without requiring any evidence of pre-retinal or choroidal neovascularization. 26 , 27 , 28 As vein occlusions can cause VEGF overproduction, avoiding to do proper management may cause tumor growth and secondary mentioned complications. 29 …”