Rapid Synthesis of  68 Ga-labeled macroaggregated human serum albumin (MAA) for routine application in perfusion imaging using PET/CT

Müeller, Dirk; Kulkarni, Harshad; Baüm, Richard; Odparlik, Andreas

doi:10.1016/j.apradiso.2017.01.003

Cited by 18 publications

(29 citation statements)

References 11 publications

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“…Our method was developed by modifying an existing method. The binding activity and radiochemical purity of our method was compatible with similar studies [15][16][17]. Our method is simple and fast because it is an automatic and closed system.…”

Section: Discussionsupporting

confidence: 60%

“…Two clinical lung perfusion studies have been performed with 68 Ga MAA. Mueller et al [16] and Hofman et al [20] stated that 68 Ga-PET/CT V/Q scanning is superior to 99m Tc-SPECT/CT V/Q scanning in a pilot study with a few patients. However, they did not provide quantitative information (about sensitivity, specificity and accuracy) due to the limited number of patients.…”

Section: Discussionmentioning

confidence: 99%

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Detection of Pulmonary Embolism with Gallium-68 Macroaggregated Albumin Perfusion PET/CT: An Experimental Study in Rabbits

Gültekin

Çayır

Uğur

et al. 2020

Preprint

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Purpose To evaluate the use of gallium-68 ( 68 Ga) macroaggregated albumin (MAA) positron emission tomography/computed tomography (PET/CT) perfusion imaging combined with Technegas single-photon emission computed tomography/computed tomography (SPECT/CT) ventilation imaging in rabbits with experimental pulmonary emboli (PE). Methods Technegas SPECT/CT ventilation and a 68 Ga-MAA PET/CT perfusion scan (V/Q scan) were performed in 12 rabbits before and one hour after artificial induction of PE. Technegas SPECT/CT and 68 Ga-MAA PET/CT images were evaluated by a nuclear medicine physician who recorded the presence, number, and location of PE on a per-lobe basis. The sensitivity, specificity, and accuracy of Technegas SPECT/CT and 68 Ga-MAA PET/CT for detecting PE were calculated using a histopathological evaluation as a reference standard. Results A total of 60 lung lobes were evaluated in 12 rabbits, and PE was detected in 20 lobes in V/Q scans and histopathological analysis. The overall sensitivity, specificity and accuracy were 100%, 100%, and 100%, respectively, for both the Technegas SPECT/CT and 68 Ga-MAA PET/CT V/Q scans. Conclusion Technegas/ 68 Ga-MAA V/Q scans have good sensitivity, specificity and accuracy in the detection of PE in this animal model study.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Detection of Pulmonary Embolism with Gallium-68 Macroaggregated Albumin Perfusion PET/CT: An Experimental Study in Rabbits

Gültekin

Çayır

Uğur

et al. 2020

Preprint

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“…Macroaggregate counts averaged about 2765000 MAA particle/vial, in conformity with the manufacturer's specifications (2-4 × 10 6 particles/vial). We started measuring the particle size of MAA commercial kits labelled with 68 Ga after 15 min incubation at 75°C, as reported in the literature [11][12][13][14]. However, optical microscopy revealed a substantial modification in MAA particle size and structure.…”

Section: Particle Size Measurement Of An Maa Commercial Kitmentioning

confidence: 99%

^99mTc-⁶⁸Ga-ICG-Labelled Macroaggregates and Nanocolloids of Human Serum Albumin: Synthesis Procedures of a Trimodal Imaging Agent Using Commercial Kits

Persico

Marenco

Matteis

et al. 2020

Contrast Media & Molecular Imaging

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Recent developments in sentinel lymph node (SLN) and radio occult lesion localization (ROLL) highlight the need for a multimodal contrast agent, providing better presurgical PET imaging and improved intraoperative mapping thanks to fluorescence detection. For this reason, we have studied a trimodal SLN/ROLL targeting agent (99mTc-68Ga-ICG) with commercially available kits of macroaggregated or nanocolloidal albumin (MA/NC-HSA). 68Ga PET imaging does provide better spatial resolution and makes it possible to predict signal intensity during surgery. The presence of 99mTc assesses the efficacy of these compounds in vitro and also during the surgery procedure. The aim of this study was to optimise the labelling and tagging of these two radiopharmaceuticals and assess their yields and stability. Kits of MA/NC-HSA particles (Pulmocis® and NanoAlbumon®) were used for sequential radiolabelling with 99mTc and 68Ga. Fluorescent tagging was performed using indocyanine green, a tricarbocyanine dye. The ITLC radiochemical purity of the trilabelled MA/NC-HSA was >95%. Fluorescent purity was measured by scanning the strips with a PhotoDynamicEye probe. Finally, in vitro stability tests, performed with DTPA and human serum solutions, assessed the efficacy of fluorescent tagging and radiolabelling.

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“…Dem generellen technischen Trend der Miniaturisierung folgend, fand 2013 die Markteinführung des Modular-Lab eazy (ML eazy) Systems statt [24,25] tik-Pumpe werden sowohl die Elution des GalliaPharm-Generators, als auch weitere Flüssigkeitstransfers innerhalb eines Formulierungsprozesses automatisiert. Der Anwender wird dabei vor unnötiger Strahlenbelastung geschützt [26].…”

Section: Therapienuklideunclassified

Präzisionsonkologie revolutioniert Nuklearmedizin mit theranostischem Ansatz

et al. 2019

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ZusammenfassungRadiopharmazeutika erleben dank spektakulärer Forschungserfolge eine Renaissance. Große Hoffnungen richten sich auf Methoden, mit denen Mediziner versteckte Krebsgeschwüre aufspüren und dann zielgenau bekämpfen können.Mit der Registrierung von 90Y als Yttriga und der bahnbrechenden weltweit ersten Zulassung des 68Ge/68Ga-Radionuklidgenerators GalliaPharm® hat Eckert & Ziegler den Weg für einen theranostischen Ansatz in der Nuklearmedizin und Onkologie geebnet.Eckert & Ziegler positioniert sich hier als Komplettanbieter für die klinische Routine und die pharmazeutische Industrie.Das Unternehmen bietet folgende Produkte aus einer Hand: Pharmazeutische Entwicklung von Liganden, die mit Nukliden für PET und Therapie auf Modular Lab-Synthesemodulen markiert werden können; Herstellung von gebrauchsfertigen Arzneimitteln für klinische Studien und Routine; Kalibrierung von Messgeräten; Herstellung von Strahlungsquellen zur Qualitätskontrolle; Kameratechnik und Strahlenschutz sowie Heißzellen für Routinesynthesen für Patienten. Eckert & Ziegler, ein starker Partner für Forscher und Kliniker, verbessert ständig seine Produkte und Dienstleistungen, um die Patienten besser zu versorgen.

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Rapid Synthesis of 68 Ga-labeled macroaggregated human serum albumin (MAA) for routine application in perfusion imaging using PET/CT

Cited by 18 publications

References 11 publications

Detection of Pulmonary Embolism with Gallium-68 Macroaggregated Albumin Perfusion PET/CT: An Experimental Study in Rabbits

Detection of Pulmonary Embolism with Gallium-68 Macroaggregated Albumin Perfusion PET/CT: An Experimental Study in Rabbits

^99mTc-⁶⁸Ga-ICG-Labelled Macroaggregates and Nanocolloids of Human Serum Albumin: Synthesis Procedures of a Trimodal Imaging Agent Using Commercial Kits

Präzisionsonkologie revolutioniert Nuklearmedizin mit theranostischem Ansatz

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Rapid Synthesis of 68 Ga-labeled macroaggregated human serum albumin (MAA) for routine application in perfusion imaging using PET/CT

Cited by 18 publications

References 11 publications

Detection of Pulmonary Embolism with Gallium-68 Macroaggregated Albumin Perfusion PET/CT: An Experimental Study in Rabbits

Detection of Pulmonary Embolism with Gallium-68 Macroaggregated Albumin Perfusion PET/CT: An Experimental Study in Rabbits

99mTc-68Ga-ICG-Labelled Macroaggregates and Nanocolloids of Human Serum Albumin: Synthesis Procedures of a Trimodal Imaging Agent Using Commercial Kits

Präzisionsonkologie revolutioniert Nuklearmedizin mit theranostischem Ansatz

Contact Info

Product

Resources

About

^99mTc-⁶⁸Ga-ICG-Labelled Macroaggregates and Nanocolloids of Human Serum Albumin: Synthesis Procedures of a Trimodal Imaging Agent Using Commercial Kits