Rapid Synthesis of Multifunctional Apatite via the Laser-Induced Hydrothermal Process

Abstract

Synthetic biomaterials are used to overcome the limited quantity of human-derived biomaterials and to impart additional biofunctionality. Although numerous synthetic processes have been developed using various phases and methods, currently commonly used processes have some issues, such as a long process time and difficulties with extensive size control and high-concentration metal ion substitution to achieve additional functionality. Herein, we introduce a rapid synthesis method using a laser-induced hydrothermal process. Based on the thermal interaction between the laser pulses and titanium, which was used as a thermal reservoir, hydroxyapatite particles ranging from nanometer to micrometer scale could be synthesized in seconds. Further, this method enabled selective metal ion substitution into the apatite matrix with a controllable concentration. We calculated the maximum temperature achieved by laser irradiation at the surface of the thermal reservoir based on the validation of three simplification assumptions. Subsequent linear regression analysis showed that laser-induced hydrothermal synthesis follows an Arrhenius chemical reaction. Hydroxyapatite and Mg2+-, Sr2+-, and Zn2+-substituted apatite powders promoted bone cell attachment and proliferation ability due to ion release from the hydroxyapatite and the selective ion-substituted apatite powders, which had a low crystallinity and relatively high solubility. Laser-induced hydrothermal synthesis is expected to become a powerful ceramic material synthesis technology.

3D-printed nanohydroxyapatite/methylacrylylated silk fibroin scaffold for repairing rat skull defects

“…The artificial manufacture of hydroxyapatite is mainly produced in the form of micron and nanometer particles [ 35 ]. However, many recent studies have shown that nanohydroxyapatite has better bone conductivity because its size is similar to natural hydroxyapatite found in bone [ 36 , 37 ].…”

Evaluation of dental implant with hydroxyapatite coating by laser-induced hydrothermal synthesis: in vitro and in vivo experimental study

“…When processing Ti6Al4V titanium alloy using LISSC, it was observed in XRD and TEM tests that the crystallinity of HA was low. This is considered to be because as HA becomes nanoparticles, the surface energy increases, and as a result, more serum proteins are attached, and bone conductivity also increases [50]. In addition, when the HA layering amount was high, the number of serum proteins and osteocytes attached to the surface increased.…”

Recent advances in vacuum- and laser-based fabrication processes for solar water-splitting cells

“…The laser processing of nanomaterials has garnered significant interest due to its precision in manipulating and modifying materials at the nanoscale. 78 This technique has found applications across various domains, including electronics, 79 bioelectronics, 80,81 energy, 82 and materials science. 83 The principal advantages of laser processing include its exceptional precision, which allows for the precise modification, cutting, and structuring of nanomaterials with minimal thermal impact on adjacent areas.…”