Rapid target analysis of microcontaminants in water by on-line single-short-column liquid chromatography combined with atmospheric pressure chemical ionization ion-trap mass spectrometry

Hogenboom, A.C.; Speksnijder, P; Vreeken, R.J.; Niessen, W.M.A.; Brinkman, U.A.Th.

doi:10.1016/s0021-9673(97)01139-4

Cited by 98 publications

(38 citation statements)

References 19 publications

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“…LC-MS mass spectra do, moreover, depend on the systems and conditions used, and matrix effects sometimes modify the signal intensity. LC coupled to a triple quadrupole is a powerful tool in pesticide residue analysis [13], but its use is currently limited to a few laboratories.…”

Section: Introductionmentioning

confidence: 99%

Influence of the solvent on the gas chromatographic behaviour of urea herbicides

2001

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SummaryDegradation products of chlorsulfuron, chlortoluron, diuron, fluometuron, isoproturon, Iinuron, metabenzthiazuron, metobromuron, and monuron formed in the gas chromatographic injector have been used for identification of the respective herbicides. Mass spectra of the derived compounds were obtained with a quadrupole mass spectrometric detector working in scan mode (20-450 amu). The compounds generated often depended on the solvent used for phenylurea herbicide injection (ethanol, methanol, dichloromethane, and acetonitrile). When methanol and ethanol were used as solvents the major products formed from phenylureas were carbamic acid esters. When acetonitrile or dichloromethane were used the main derivatives were phenylisocyanates. Chlorsulfuron and metabenzthiazuron, however, generated a triazine plus a phenylsulfonamide and a benzothiazolamine, respectively, irrespective of the solvent used. Linuron and diuron behaved similarly and gave degradation products with the same mass spectra. The thermal reactions occurred instantaneously in the injector block and were promoted by the high temperature selected (300 ~ Determination of the compounds derived from urea herbicides, by use of a 30 m BP10 column and a selected ion registering (SIR) program based on l",,vo or three ions, can be used for sensitive detection of the presence of urea herbicides in environmental extracts. With standards in methanol instrument detection limits ranged from 02 pg for chlorsulfuron (detected as 2-chlorobenzensulfonamide) to 1 pg for monuron and metobromuron (both detected as their carbamic acid methyl esters). RSDwere below 9% at the 5 ng L 1 level. The response was linearly dependent on quanti b, (r> 0.9986) in the 5 ng L 1 to 25 I~g L 1 range. Unequivocal identification of some phenylurea herbicides was not always possible because some herbicides with similar structures, for example diuron and hnuron, gave the same derivative.

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Section: Introductionmentioning

confidence: 99%

Influence of the solvent on the gas chromatographic behaviour of urea herbicides

2001

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“…An increasing number of publications of results of investigations conducted with these couplings using atmospheric interfaces, illustrate the large potential of this technique combined upstream with liquid/solid preconcentration methods, in-line or off-line [10][11][12][13][14][15]. Results obtained with this coupling in connection with a study on the surface waters of the Centre region in France and dealing with a portion of the 40 pesticides or conversion products selected in accordance with the criteria of an approach inspired by CORPEN 1 [16] are presented here.…”

Section: Introductionmentioning

confidence: 99%

High-performance liquid chromatography coupled with mass spectrometry applied to analyses of pesticides in water. Results obtained in HPLC/MS/APCI in positive mode

Jeannot

Sauvard

1999

Analusis

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Abstract. Determinations of pesticides and their degradation products in natural waters, given the great heterogeneity of the substances involved, conventionally demands the use of the following analytical methods:• gas chromatography with different specific detectors such as the electron capture detector, NPD thermo-ionic detector, and mass spectrometry, • high-performance liquid chromatography combined with a diode array ultraviolet detector or a spectrofluorimeter after derivatization, • thin-layer chromatography (TLC) with detection of the isolated substances by UV. With liquid chromatography, the most widely used detector is the diode-array UV detector. This method, recommended in French standard AFNOR T 90 123 (EN ISO 11369) [1], represents a significant advance in the approach to the identification of polar substances detected in unknown samples, compared with the results obtained by UV detection with a single wavelength. However, this method of detection does not guarantee the identification of the detected substances in absolute terms. Confirmation on a second column or by gas chromatography is therefore necessary. The atmospheric interfaces equipped with APCI (Atmospheric Pressure Chemical Ionization) or ESI (Electrospray Ionization) ion sources help to broaden the field of application of the couplings of liquid chromatography with mass spectrometry, and have seen substantial developments in recent years [2][3][4]. They offer performance in agreement with environmental requirements in terms of quantification limits, sensitivity, simplicity of use and reliability [5]. They are accordingly suitable for the identification and quantification of pesticides and their conversion products in waters [6,7]. This article presents a summary of the results obtained on surface waters with the APCI interface in positive ionization mode, after extraction of the pesticides at neutral pH. The analyses were performed as part of a multi-residue approach applied to a priority list of 40 pesticides to be determined in the surface waters of the Centre region of France. In addition to high-performance liquid chromatography combined with the diode array UV detector and coupled with mass spectrometry, gas chromatography coupled with mass spectrometry was used as a technical complement, because of its suitability for apolar substances such as lindane, organochlorinated pesticides, certain organophosphorus pesticides, trifluraline etc. For the other substances investigated, such as triazines and some of their degradation products, phenylureas, triazoles, amides and carbamates, high-performance liquid chromatography coupled in series with a UV detector and a mass spectrometer was employed. The results obtained with the diode array UV detector were compared with those obtained with the mass spectrometer in order to validate the results obtained with the latter detector. Acquisition and quantification methods optimized for HPLC/MS with APCI interface in positive ionization mode are presented in the article. Results on samples of sur...

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“…tography (LC)-mass spectrometry (MS) [5,6], SPE-LC-diode array detection (DAD) [7] and SPE-gas Atrazine and simazine are mainly released into the chromatography (GC)-MS [8], the use of largeenvironment by agricultural and industrial processes.…”

Section: Introductionmentioning

confidence: 99%

Analysis of trace atrazine and simazine in environmental samples by liquid chromatography–fluorescence detection with pre-column derivatization reaction

Gong

1998

Journal of Chromatography A

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Coupled with off-line extraction, a pre-column derivatization liquid chromatographic fluorescence detection (LC-FL) procedure was developed for the determination of atrazine and simazine in soil, crop and water samples. Concentrations in real samples were expected to be at or below the low ng / g level, which requires pre-concentration of analytes and improved detection. 4-(2-Phthalimidyl) benzoyl chloride (PIB-Cl) was used as a pre-column derivatization reagent for highperformance liquid chromatography. The clean-up and second-time concentration procedures, which were indispensable in the conventional analytical methods for soil and crop analysis because of the complexity of the samples, were replaced by a derivatization reaction between PIB-Cl and the analytes. The fluorescent and ultraviolet characteristics of the derivatives were investigated. The derivatization reaction and chromatographic separation conditions were optimized systematically. Detection limits of 1.2 ng / g for atrazine and 1.1 ng / g for simazine were obtained with recoveries of 84-95% for environmental samples. On the basis of practical application to five soil and five crop samples, the LC-FL method was compared with the conventional GC-MS method.

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Rapid target analysis of microcontaminants in water by on-line single-short-column liquid chromatography combined with atmospheric pressure chemical ionization ion-trap mass spectrometry

Cited by 98 publications

References 19 publications

Influence of the solvent on the gas chromatographic behaviour of urea herbicides

Influence of the solvent on the gas chromatographic behaviour of urea herbicides

High-performance liquid chromatography coupled with mass spectrometry applied to analyses of pesticides in water. Results obtained in HPLC/MS/APCI in positive mode

Analysis of trace atrazine and simazine in environmental samples by liquid chromatography–fluorescence detection with pre-column derivatization reaction

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