2007
DOI: 10.1590/s0100-879x2006005000057
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Rapid test for the evaluation of the activity of the prodrug hydroxymethylnitrofurazone in the processing of Trypanosoma cruzi messenger RNAs

Abstract: No fully effective treatment has been developed since the discovery of Chagas' disease by Carlos Chagas in 1909. Since drug-resistant Trypanosoma cruzi strains are occurring and the current therapy is effectiveness in the acute phase but with various adverse side effects, more studies are needed to characterize the susceptibility of T. cruzi to new drugs. Many natural and/or synthetic substances showing trypanocidal activity have been used, even though they are not likely to be turned into clinically approved … Show more

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Cited by 6 publications
(1 citation statement)
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“…Y strain is considered the standard one and a good candidate for first screening for new trypanocidal agents, and BOL strain showed to be more resistant than Y strain to nifurtimox and benznidazole on in vivo assay. Besides, they have been showing different growth features in culture (Silva and Nussenzweig 1953;Martinez-Diaz et al 2001;Barbosa et al 2007). …”
Section: Introductionmentioning
confidence: 99%
“…Y strain is considered the standard one and a good candidate for first screening for new trypanocidal agents, and BOL strain showed to be more resistant than Y strain to nifurtimox and benznidazole on in vivo assay. Besides, they have been showing different growth features in culture (Silva and Nussenzweig 1953;Martinez-Diaz et al 2001;Barbosa et al 2007). …”
Section: Introductionmentioning
confidence: 99%