In this research work, an effort has been made to study the influence of selected input parameters on the dimensional accuracy (linear as well as radial) and surface finish of polyurethane prototypes fabricated by vacuum casting (VC) process as a case study. The master pattern required for making a silicone mould has been fabricated by fused deposition modelling and its surface finish has been enhanced by chemical vapour smoothing process. Maximum shrinkage of 2.29 and 4.77% has been observed in the selected linear and radial dimension, respectively, after the VC process. Optimal parameter settings that were different for both the dimensions as well as surface finish have been obtained using Taguchi's L18 orthogonal array. Finally, parameter setting that simultaneously minimizes the dimensional deviation and surface roughness has been found out using response optimization module of Minitab 17 software and the results obtained have been verified by performing the confirmation experiments. The tolerance grades for the selected dimension of the prototypes were found to be acceptable as per the ISO standard UNI EN 20286-I (1995) and DIN16901 for plastic materials. In addition, the C pk value greater than 1.3 indicated that the proposed process is highly capable. The surface finish and dimensional accuracy of prototypes are at par with the traditional moulding patterns, and hence, they can be used as end-products or plastic-based master patterns for investment casting applications.