Rapid tumor inhibitionviamagnetic hyperthermia regulated by caspase 3 with time-dependent clearance of iron oxide nanoparticles

Abstract

Among conventional cancer therapies, radio-frequency magnetic hyperthermia (MHT) has widely been investigated for magnetic nanoparticles (MNPs). However, majority of in vivo biodistribution studies have tested very low MNP dosages (equivalent...

Superparamagnetic iron oxide nanoparticles for magnetic hyperthermia: recent advancements, molecular effects, and future directions in the omics era

“…Chauhan et al studied the in vivo tumour inhibition with chitosan-coated IONPs + AMF, by finding a good balance between safe IONPs concentration/AMF conditions and treatment efficacy. 102 The aim was, in fact, to trigger apoptosis instead of necrosis, in order to reduce possible side effects due to a strong response of the immune system induced by necrosis. By choosing AMF conditions below the recommended limit of H × f and by using relatively low SPION concentrations (≈ 2 Please do not adjust margins Please do not adjust margins µg/mm 3 ), administered by intratumour injections to reduce nanoparticles leakage towards other body areas, they were able to achieve tumour removal with temperatures below 45°C, triggering apoptosis instead of necrosis, with lower side effects.…”

Spatiotemporal control of engineered bacteria to express interferon-γ by focused ultrasound for tumor immunotherapy

“…The average tumor volume of the mice treated with URB + US was less than 250 mm 3 , whereas that of other treated groups are more than 1000 mm 3 . Slight anti-tumor effect of US, E. coli or URB, or E. coli groups could be observed in our study, which may attribute to 30-min hyperthermia at 45 °C produced by US, the presence of lipopolysaccharide in the bacteria or nutrient competition due to bacterial growth [38][39][40] . The median survival time of mice in URB + US group increased to 60 days compared with 42 days for control group, which proved that application of URB combined with ultrasound irradiation could improve survival rate significantly.…”

Combination of Ablation and Immunotherapy for Hepatocellular Carcinoma: Where We Are and Where to Go

“…Similarly, in other solid tumors, RFA can not only reduce the proportions of immunosuppressive cells (including Treg cells, tumor-associated macrophages and neutrophils), but increase the T cell infiltration as well as expression of the immune checkpoints (PD-1/PD-L1 and lymphocyte-activation gene 3 [LAG3]) in RFA-treated tumors and distant non-RFA tumors (70,71). Moreover, serum and intra-tumoral cytokines, such as IFN-g, IL-1a/b, IL-2/6/8/10, and TNFa/b, were also increased or activated (64,(72)(73)(74)(75).…”