Rapid ultrasound‐assisted microextraction of atorvastatin in the sample of blood plasma by nickel metal organic modified with alumina nanoparticles

Abstract

In the present work, nickel-1,4-benzenedioxyacetic acid was synthesized as a rod-like metal organic material and then modified with alumina nanoparticles to synthesize nickel metal organic modified-Al 2 O 3 nanoparticles. The material was found as an efficient sorbent for the enrichment of atorvastatin in human blood plasma. After the extraction of the sample of plasma by ultrasound-assisted dispersive solid phase extraction, high performance liquid chromatographyultraviolet was used to determine the quantitatively pre-concentrated interest analyte. The conditions for optimum extraction were achieved by the optimization of the volume of eluent, dosage of the sorbent, and time of sonication. Solution pH of 7.0, 250 μL of ethanol, 45 mg of the sorbent, and 10 min of sonication time were the conditions for extracting the atorvastatin maximum recovery of higher than 97.0%. By using desirability function for the optimization of the process, the present method showed a response that was linear ranging from 0.2 to 800 ng/mL with regression coefficient of 0.999 in the plasma of human blood with a satisfactory detection limit of 0.05 ng/mL, while the precision of interday for the current method was found to be <5%. It can be concluded that dispersive solid phase extraction method is effective for the extraction of atorvastatin from human plasma samples (97.4-102%) due to its easy operation, simplicity, repeatability, and reliability.

Ultrasound assisted supramolecular liquid phase microextraction procedure for Sudan I at trace level in environmental samples

“…SUPRAS increases extraction efficiency by interacting with molecules and decreasing the extraction time. The amount of mixing alkanol and THF used in the formation of SUPRAS is very important [25][26][27][28][29][30][31][32]. According to our knowledge, microextraction studies of Sudan I with supramolecular solvents have not been performed before.…”

Trace determination of antifungal drugs in biological fluids through a developed approach of hydrogel‐based spin‐column micro‐solid‐phase extraction followed by LC‐MS/MS analysis

“…Biological fluids such as blood samples are complex matrices, and antifungal drugs are present in such matrices at trace levels making analysis troublous without the sample pretreatment procedures. So, there is a demand for the employment of sample preparation methods before any instrumental analysis to cleanup and preconcentration [7]. Efforts for finding more efficient, eco-friendly, rapid, and economical sample preparation methods have led to the development of miniaturized extraction methods.…”