Rapid Weight Reduction and Psoriasis

Zackheim, Herschel S.

doi:10.1001/archderm.1971.04000140022004

Cited by 15 publications

(3 citation statements)

References 10 publications

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“…143 High levels of worry and stress have been found to aggravate disease activity, and aggravate the therapeutic benefit of Psoralen and UVA therapy (PUVA). 144 Attempts to look at diet including diets rich in zinc, 145 and turkey meat, 146 diets low in tryptophan, 147 protein, 148 or calories 149 seem to have little impact. As mentioned before, in patients with both celiac disease and psoriasis, diets low in gluten have been shown to be useful in improving both conditions.…”

Section: Management Of Psoriasis and Psoriatic Arthritismentioning

confidence: 99%

Psoriasis

Fernández-Obregón¹

2012

Psoriasis - A Systemic Disease

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Section: Management Of Psoriasis and Psoriatic Arthritismentioning

confidence: 99%

Psoriasis

Fernández-Obregón¹

2012

Psoriasis - A Systemic Disease

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“…Diet is unimpor tant. Addition of zinc [Voorhees et a l, 1969] or turkey meat [Ellis el al., 1968] and reduction in tryptophan [Farber and Zackheim, 1967], protein [Zackheim and F arber, 1969] and calories [Zackheim and Farber, 1971] do not affect the disease. A therapeutic holiday in the Southern sunshine may be helpful [Molin, 1972],…”

Section: Managementmentioning

confidence: 99%

Psoriasis: A Review. II

Baker¹

1975

Dermatology

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Notwithstanding the intense interest in systemic cytotoxic therapy in recent years, the great majority of psoriatics are likely to go on needing topical therapy with tar, dithranol or corticosteroids, and a welcome trend is the spreading of interest in day care centres such as those in Paris (Grupper), Stockholm (Thyresson), Stanford (Farber) and San Francisco (Cram) evolving from the out-patient regimes advocated by Ingram in Leeds a generation ago.

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“…38 Dietary zinc has also attracted some attention, because of the parakeratotic rash in pigs taking a zinc-deficient diet. Plamsa zinc concentrations have indeed been found to be decreased in psoriasis by some 39 41 but not by others.…”

Section: Role Of Dietmentioning

confidence: 99%

Research into psoriasis--the last decade.

Shuster¹

1971

BMJ

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Psoriasis is an infuriating disease. It is an arrogantly trivial disorder placqued on to a systemically unimportant organ. Yet it affects 1-2% of the population,62 some of whom are so badly afflicted that life is reduced to a biological chore. This is the frustration: the psoriatic without his spots is totally fit. So that, in terms of personal happiness and social usefulness, research into psoriasis has more to achieve than many of the spectacular endeavours of contemporary medical science. All of us Increased Metabolic Activity As would be expected from the histological and histochemical findings there is much biochemical evidence of increased metabolic activity with increased oxygen consumption in the plaques." K. M. Halprin and A. Okawia studied carbohydrate metabolism in the lesions and in normal looking skin between the lesions.74 They found no enzyme deletions or gross reduction, and therefore rejected the idea of a specific enzyme defect in an important metabolic pathway. What they did find led them to the important general conclusion that "the reorganization of cellular metabolism necessary to sustain the increased rate of proliferation in the psoriatic plaque, occurs not by increasing the concentration of one or few key enzymatic steps but by increasing each of the enzymes responsible for a whole series of reactions . . ." Almost all the biochemical, and many of the histochemical studies point in the same direction; a general increase in metabolism within the plaques and no specific biochemical defect.The histological suspicion of increased mitotic activity in the epidermis has now been confirmed in a number of ways.S. Rothberg and his colleagues showed the rapid passage of 14-C glycine through the epidermis,75 but the most satisfying of the earlier analyses was that of E. J. van Scott and T. M. Eckel,76 who showed the speed-up of epidermal turnover by histiometric methods. The advances which followed owe themselves to the method of local injection of isotopes intradermally and subsequent analysis either by autoradiography77 78 or by scintillation counting.79 These and other studies show that in the psoriatic plaques epidermal turnover is about 10 times faster than in the skin of normal people. This rapid turnover occurs in both germinative cell layer and the granular layers.77 9 It is well known from conventional histology that there are many more suprabasal mitotic cells in psoriatic than in normal skin. I find it an intriguing paradox that the increase shown autoradiographically80 is not as great as the increa'e shown by conventional histology. Could this mean that the duration of mitosis is less in suprabasal than in basal cells in psoriasis?Abnormal Keratinization There have been a good many studies, particularly histochemical, of the abnormal keratinization in psoriasis67 71 72 and its relationship to the depleted granular cell layer. One early study showed a change in the x-ray diffraction pattern of the keratin, suggesting an abnormal aggregation of the keratin fibrils.81 The crystalline ...

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Rapid Weight Reduction and Psoriasis

Cited by 15 publications

References 10 publications

Psoriasis

Psoriasis

Psoriasis: A Review. II

Research into psoriasis--the last decade.

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