Rapidly–Dissolvable Microneedle Patches Via a Highly Scalable and Reproducible Soft Lithography Approach

Moga, Katherine A.; Bickford, Lissett R.; Geil, Robert D.; Dunn, Stuart S.; Pandya, Ashish; Wang, Yapei; Fain, John; Archuleta, Christine F.; O’Neill, Adrian T.; DeSimone, Joseph M.

doi:10.1002/adma.201300526

Cited by 122 publications

(83 citation statements)

References 24 publications

(67 reference statements)

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“…This manner of achieving scalability by controlling the spatial distribution of UV exposure offers greater simplicity compared with previously developed microneedle fabrication techniques [10][11][12][13] . In addition, the present method can be used to fabricate microneedle arrays, whereas the previously developed inclined/rotated UV lithography method cannot directly produce microneedle shapes 11,16 . By virtue of this ability to directly fabricate microneedle arrays, the molding step can be eliminated, thereby simplifying the microneedle fabrication process.…”

Section: Resultsmentioning

confidence: 99%

“…In previous studies, inclined/rotated UV lithography has been used to obtain concave-shaped mold masters for microneedle fabrication (Supplementary Figure S1). This approach, compared with the direct fabrication of conical microneedle structures 11,16 , requires an additional molding step. Furthermore, no theoretical analysis of such inclined/rotated UV exposure has yet been performed, and this lack of a theoretical foundation hinders the understanding and use of inclined/rotated UV lithography for microneedle fabrication.…”

Section: Introductionmentioning

confidence: 99%

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Scalable fabrication of microneedle arrays via spatially controlled UV exposure

et al. 2016

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This paper describes a theoretical estimation of the geometry of negative epoxy-resist microneedles prepared via inclined/rotated ultraviolet (UV) lithography based on spatially controlled UV exposure doses. In comparison with other methods based on UV lithography, the present method can create microneedle structures with high scalability. When negative photoresist is exposed to inclined/rotated UV through circular mask patterns, a three-dimensional, needle-shaped distribution of the exposure dose forms in the irradiated region. Controlling the inclination angles and the exposure dose modifies the photo-polymerized portion of the photoresist, thus allowing the variation of the heights and contours of microneedles formed by using the same mask patterns. In an experimental study, the dimensions of the fabricated needles agreed well with the theoretical predictions for varying inclination angles and exposure doses. These results demonstrate that our theoretical approach can provide a simple route for fabricating microneedles with on-demand geometry. The fabricated microneedles can be used as solid microneedles or as a mold master for dissolving microneedles, thus simplifying the microneedle fabrication process. We envision that this method can improve fabrication accuracy and reduce fabrication cost and time, thereby facilitating the practical applications of microneedle-based drug delivery technology.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Scalable fabrication of microneedle arrays via spatially controlled UV exposure

et al. 2016

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“…Microneedle geometry is a critical parameter affecting skin penetration and consequently, a variety of techniques have been employed to prepare different geometry microneedles [29][30][31] . Laser micromachining is a suitable technique for preparing microneedles of different geometries as it allows parameters such as the geometry of the needle and interspacing to be almost infinitely varied.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of geometrical effects of microneedles on skin penetration by CT scan and finite element analysis

Loizidou

Inoue

Ashton-Barnett

et al. 2016

European Journal of Pharmaceutics and Biopharmaceutics

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Computerized tomography (CT scan) imaging and finite element analysis were employed to investigate how the geometric composition of microneedles affects their mechanical strength and penetration characteristics. Simulations of microneedle arrays, comprising triangular, square and hexagonal microneedle base, revealed a linear dependence of the mechanical strength to the number of vertices in the polygon base. A laser-enabled, micromoulding technique was then used to fabricate 3x3 microneedle arrays, each individual microneedle having triangular, square or hexagonal base geometries. Their penetration characteristics into ex-vivo porcine skin, were investigated for the first time by CT scan imaging. This revealed greater penetration depths for the triangular and square-based microneedles, demonstrating CT scan as a powerful and reliable technique for studying microneedle skin penetration.

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“…PRINT process can easily be adapted to create an array of discrete microneedles of the desired chemical composition attached to a flexible, water-soluble substrate. 31 This application of PRINT can be particularly useful for skin delivery of vaccines. 27 In summary, the field of nanotechnology is becoming mature enough to contribute powerfully to vaccinology.…”

Section: Discussion and Future Prospectsmentioning

confidence: 99%

Engineered PRINT^® nanoparticles for controlled delivery of antigens and immunostimulants

Beletskii

Galloway

Rele

et al. 2014

Human Vaccines & Immunotherapeutics

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Particle replication in non-wetting templates (PRINT) is a novel nanoparticle platform that provides compositional flexibility with the ability to specify size and shape in formulating vaccines. The PRINT platform also offers manufacturing and cost advantages over traditional particle technologies. Across multiple antigen and adjuvant formulations, robust antibody and cellular responses have been achieved using PRINT particles in mouse models. Preclinical studies applying PRINT technology in the disease areas of influenza, malaria, and pneumonia are described in this commentary. The proof of principle studies pave the way toward significant cost-effective solutions to global vaccine supply needs.

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Rapidly–Dissolvable Microneedle Patches Via a Highly Scalable and Reproducible Soft Lithography Approach

Cited by 122 publications

References 24 publications

Scalable fabrication of microneedle arrays via spatially controlled UV exposure

Scalable fabrication of microneedle arrays via spatially controlled UV exposure

Evaluation of geometrical effects of microneedles on skin penetration by CT scan and finite element analysis

Engineered PRINT^® nanoparticles for controlled delivery of antigens and immunostimulants

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Rapidly–Dissolvable Microneedle Patches Via a Highly Scalable and Reproducible Soft Lithography Approach

Cited by 122 publications

References 24 publications

Scalable fabrication of microneedle arrays via spatially controlled UV exposure

Scalable fabrication of microneedle arrays via spatially controlled UV exposure

Evaluation of geometrical effects of microneedles on skin penetration by CT scan and finite element analysis

Engineered PRINT® nanoparticles for controlled delivery of antigens and immunostimulants

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Product

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Engineered PRINT^® nanoparticles for controlled delivery of antigens and immunostimulants