Rapidly Evolving Necrotic Plaques and Nodules in a Middle-aged Woman

Wessman, Laurel L.; Gaddis, Kevin J.; Pearson, David R.

doi:10.1001/jamadermatol.2019.4992

Cited by 1 publication

(1 citation statement)

References 14 publications

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“…e presence of keratinocyte necrosis indicates the cytotoxic nature of the tumor cells [2,[4][5][6]. Immunohistochemically, the CD3+, CD8+, CD4-, CD45RA+, CD45RO−, granzyme B+, perforin+, TIA-1+, and beta-F1+ phenotype is constant.…”

Section: Discussionmentioning

confidence: 99%

Nasolabial Ulcerated Placard Revealing a Primary Cutaneous Aggressive Epidermotropic CD8+ T-cell Lymphoma

Ntihebuwayo

Hali

Kerouach

et al. 2022

Case Reports in Dermatological Medicine

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Primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma is a rare entity representing less than 1% of cutaneous lymphomas. It has an aggressive clinical manifestation with a poor prognosis. It is characterized by cytotoxic and epidermotropic CD8+ proliferation. It also expresses the TIA-1 marker. We report a new case for its display and aggressive character, diagnostic difficulty, and good therapeutic response to chemotherapy. This is a 62-year-old female patient admitted to the hospital for a nasolabial ulcerated placard evolving for two years. Clinical examination revealed submandibular lymph nodes. The specimen analysis associated with anatomoclinical manifestation was concluded for a primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma. Tumor extent assessment did not show any secondary localization. The blood tests and serology were unremarkable. The patient had benefited from a CHOEP-type multidrug therapy protocol with complete healing of the lesion after three courses of chemotherapy.

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Section: Discussionmentioning

confidence: 99%