Rapidly Fatal Haemophilus influenzae Serotype f Sepsis in a Healthy Child

Zacharisen, Michael C.; Watters, S.K.; Edwards, Justin

doi:10.1053/jinf.2002.1100

Cited by 11 publications

(5 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consequently, in general, patients with Hif infections recovered uneventfully, while those with Hie infections either died or developed further complications. 1 We find patient's B fatal case, as well as the fatal Hif septicemia case reported by Zacharisen et al 7 in an otherwise healthy 4-year-old girl without underlying predisposing conditions to be in opposition to these observations. Although undetected immunodeficiency cannot be excluded, these 2 cases are bothering, as symptoms of infection were very acute in nature and the outcome rapidly fatal.…”

Section: Discussionsupporting

confidence: 57%

Invasive Haemophilus influenzae Serotype f Case Reports in Mazovia Province, Poland

et al. 2016

View full text Add to dashboard Cite

After successful introduction of anti-Haemophilus influenzae (Hi) serotype b vaccination program in Poland, invasive non-b or nontypeable H. influenzae infections have been reported more frequently alike in other countries all over the world. In this paper, we report 2 cases of H. influenzae serotype f (Hif) meningitis with severe clinical presentations which are rarely seen in previously healthy children.The first case is a 6-year-old girl who was admitted to pediatric ward with signs of meningitis. Laboratory tests confirmed bacteremic meningitis caused by Hif. The girl responded very well to administered treatment and recovered without any further complications. No underlying comorbidities were found. The second patient was a 4-year-old boy who, in course of Hif bacteremic meningitis, developed rapid septicemia and, despite aggressive treatment, died within a few hours of hospitalization. The child's past history was unremarkable.By presenting these cases, we would like to remind clinicians that invasive non-b Hi infections can become fatal not only in the group of the youngest children or children with coexisting comorbidities, as most commonly reported in the worldwide literature. At the same time, we want to emphasize the legitimacy of constant monitoring Hi epidemiology in order to take accurate actions if necessary.

show abstract

Section: Discussionsupporting

confidence: 57%

Invasive Haemophilus influenzae Serotype f Case Reports in Mazovia Province, Poland

et al. 2016

View full text Add to dashboard Cite

show abstract

“…In some countries, only Hib disease is reportable; therefore, information on other serotypes is lacking. However, numerous case reports of invasive H. infl uenzae disease caused by encapsulated non-b serotypes, particularly types a, e, and f, have been published (6,10,11,(18)(19)(20).…”

mentioning

confidence: 99%

Epidemiology ofHaemophilus influenzaeSerotype a, North American Arctic, 2000–2005

Bruce

Deeks

Zulz

et al. 2008

Emerg. Infect. Dis.

View full text Add to dashboard Cite

show abstract

“…Invasive Hif disease now contributes to a substantial proportion of all invasive H. influenzae disease (39,43) and has been associated with infections such as bacteremia, endocarditis, and a mycotic aneurysm (1,8,35). Recently, Hif was isolated from a case of rapidly fatal sepsis in an otherwise healthy child (45).…”

mentioning

confidence: 99%

GeneticAnalysis of the Capsule Locus of Haemophilus influenzae Serotypef

2003

View full text Add to dashboard Cite

A 19-kb DNA region containing genes involved in the biosynthesis of the capsule of Haemophilus influenzae serotype f (Hif) has been cloned and characterized. The Hif cap locus organization is typical of group II capsule biosynthetic loci found in other H. influenzae serotype b bacteria and other gram-negative bacteria. However, the Hif cap locus was not associated with an IS1016 element. Three new open reading frames, Fcs1, Fcs2, and Fcs3, were identified in the Hif capsule-specific region II. The chromosomal location of the Hif cap locus and the organization of the flanking sequences differed significantly from previously described division I H. influenzae serotypes.

show abstract

Rapidly Fatal Haemophilus influenzae Serotype f Sepsis in a Healthy Child

Cited by 11 publications

References 12 publications

Invasive Haemophilus influenzae Serotype f Case Reports in Mazovia Province, Poland

Invasive Haemophilus influenzae Serotype f Case Reports in Mazovia Province, Poland

Epidemiology ofHaemophilus influenzaeSerotype a, North American Arctic, 2000–2005

GeneticAnalysis of the Capsule Locus of Haemophilus influenzae Serotypef

Contact Info

Product

Resources

About