Rapidly Fatal Outcome of Bacteremic Klebsiella pneumoniae Pneumonia in Alcoholics

Jong, G.M.T. de; Hsiue, Tzuen Ren; Chen, Cheng-Ren; Chang, Han-Yu; Chen, Chang-Wen

doi:10.1378/chest.107.1.214

Cited by 144 publications

(101 citation statements)

References 22 publications

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“…For example, chronic alcoholics have an increased incidence and higher mortality rate related to bacterial pneumonia (de Roux et al, 2006;elEbiary et al, 1997;Jong et al, 1995) and a three-fold increase in incidence of infection and sepsis after surgery (von Dossow et al, 2004). In HIV patients, concurrent alcohol consumption increases the susceptibility to various infections (Justice et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Maternal alcohol ingestion reduces surfactant protein A expression by preterm fetal lung epithelia

Lazic¹,

Wyatt²,

Matić³

et al. 2007

Alcohol

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In addition to neurodevelopmental effects, alcohol consumption at high levels during pregnancy is associated with immunomodulation and premature birth. Premature birth, in turn, is associated with increased susceptibility to various infectious agents such as Respiratory Syncytial Virus (RSV). The initial line of pulmonary innate defense includes the mucociliary apparatus, which expels microorganisms trapped within the airway secretions. Surfactant proteins A and D (SP-A and SP-D, respectively) are additional components of pulmonary innate immunity and have an important role in pulmonary defense against inhaled pathogens. The purpose of this study was to determine if chronic alcohol consumption during the third trimester of pregnancy alters the function of the mucociliary apparatus and expression of SP-A and SP-D of fetal lung epithelia. Sixteen, date-mated ewes were assigned to two different groups; an ethanol exposed group in which ewes received ethanol through surgically implanted intra-abomasal cannula during the third trimester of pregnancy, and a control group in which ewes received the equivalent amount of water instead of ethanol. Within these two groups, ewes were further randomly assigned to a full-term group in which the lambs were naturally delivered, and a pre-term group in which the lambs were delivered prematurely via an abdominal incision and uterotomy. Ethanol was administered 5 times a week as a 40% solution at 1gr/kg of body weight. The mean maternal serum alcohol concentration (SAC) measured 6 hr post administration was 16.3 +/− 4.36 mg/dL. Tracheas from 6 full-term lambs were collected to assess ciliary beat frequency (CBF). The lung tissue from all (24) lambs was collected for immunohistochemistry (IHC) analysis of SP-A and SP-D protein production and fluorogenic realtime quantitative polymerase chain reaction analysis (qPCR) of SP-A and SP-D mRNA levels. Exposure to ethanol during pregnancy significantly blocked stimulated increase in CBF though ethanol-mediated desensitization of cAMP-dependant protein kinase (PKA). In addition, pre-term born/ethanol-exposed lambs showed significantly decreased SP-A m-RNA expression when compared to the pre-term born/control group (p=0.004); no significant changes were seen with SP-D. The full-term/ethanol exposed lambs had no significant alterations in mRNA levels, but had significantly less detectable SP-A protein when compared to the full-term/control lambs (p=0.02).Corresponding author: Tatjana Lazic, DVM, MS, 2740 Veterinary Medicine, Department of Veterinary Pathology, Iowa State University, Ames, Iowa 50011-1250, 515-294-6688, FAX 515-294-5423, tlazic@iastate.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process error...

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Section: Discussionmentioning

confidence: 99%

Maternal alcohol ingestion reduces surfactant protein A expression by preterm fetal lung epithelia

Lazic¹,

Wyatt²,

Matić³

et al. 2007

Alcohol

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“…7 Alcohol abuse was defined as liver disease in a patient who maintained a daily consumption of ≥ 80 g of alcohol per day for at least the preceding 2 years. 13 The presence of coronary artery disease was determined based on preadmission history and medical records associated with myocardial infarction or angina pectoris.…”

Section: Methodsmentioning

confidence: 99%

Predictors and outcome of seizures after spontaneous intracerebral hemorrhage

Yang¹,

Lin

Chang

et al. 2009

JNS

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Object. Seizures are an important neurological complication of spontaneous intracerebral hemorrhage (ICH).A better understanding of the risk factors of seizures following ICH is needed to predict which patients will require treatment.Methods. Two hundred and forty-three adult patients were enrolled in this 1-year retrospective study. Multiple logistic regression was used to evaluate the relationship between baseline clinical factors and the presence or absence of seizure during the study period.Results. Seizures occurred in 20 patients with ICH, including acute symptomatic seizures in 9 and unprovoked seizures in 11. None progressed to status epilepticus during hospitalization. After a minimum 3-year follow-up period, the mean Glasgow Outcome Scale score was 3.8 ± 1.1 for patients who had had seizures and 3.5 ± 1.3 for those who had not. The multiple logistic regression model demonstrated that the mean ICH volume was independently as sociated with seizures, and any increase of 1 mm 3 in ICH volume increased the seizure rate by 2.7%. Conclusions. Higher mean ICH volumes at presentation were predictive of seizure, and the presence of late seizures was predictive of developing epilepsy. Most seizures occurred within 2 years of spontaneous ICH over a minimum of 3 years of follow-up. (DOI: 10.3171/2009.2.JNS081622) KeY WorDs • outcome • risk factor • seizure • spontaneous intracerebral hemorrhage 87Abbreviations used in this paper: AED = antiepileptic drug; GCS = Glasgow Coma Scale; GOS = Glasgow Outcome Scale; ICH = intracerebral hemorrhage; ROI = region of interest.

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“…CPS of K. pneumoniae has been shown to behave as a partial barrier against O-specific antibodies (9,23). In the present study, we describe the binding of MAbs against different regions of the O antigen of K. pneumoniae to their epitopes on intact bacterial cells and the effects of various capsule serotypes on this binding and on subsequent functional activity of these MAbs.…”

Section: Discussionmentioning

confidence: 89%

“…CPS of K. pneumoniae has been shown to behave as a partial barrier against O-specific antibodies (9,23). This property, however, depends on the capsular serotype since CPS serotype K1 acts as a complete barrier (23) whereas CPS serotype K2 permits partial penetration of anti-O-antigen antibodies (9,27).…”

Section: Discussionmentioning

confidence: 99%

Binding to and Opsonophagocytic Activity of O-Antigen-Specific Monoclonal Antibodies against Encapsulated and NonencapsulatedKlebsiella pneumoniaeSerotype O1 Strains

et al. 2000

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Rapidly Fatal Outcome of Bacteremic Klebsiella pneumoniae Pneumonia in Alcoholics

Cited by 144 publications

References 22 publications

Maternal alcohol ingestion reduces surfactant protein A expression by preterm fetal lung epithelia

Maternal alcohol ingestion reduces surfactant protein A expression by preterm fetal lung epithelia

Predictors and outcome of seizures after spontaneous intracerebral hemorrhage

Binding to and Opsonophagocytic Activity of O-Antigen-Specific Monoclonal Antibodies against Encapsulated and NonencapsulatedKlebsiella pneumoniaeSerotype O1 Strains

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