Rapidly growing cutaneous nodules in a sheep worker

Two cases of human orf resembling intravascular lymphoma, angiolymphoid hyperplasia with eosinophilia, and lymphomatoid papulosis

“…Although milker's nodules have a long-established record of CD30 reactivity, with multiple case reports since their initial description, 9 the presence of CD30 + atypical lymphocytes in orf has only recently been documented in 2 cases and such cells were present only within the dermis. 5 , 10 In case 1, the reactive vascular proliferation with vessels lined by plump endothelial cells accompanied by a brisk lymphocytic infiltrate with many eosinophils also bore some histologic resemblance to angiolymphoid hyperplasia with eosinophilia, the pathogenesis of which has also been tied to local production of vascular endothelial growth factor. 11 Histopathologic resemblance of Parapoxvirus -induced lesions to angiolymphoid hyperplasia with eosinophilia has not been described in literature, to our knowledge.…”