Rapidly in situ forming an injectable Chitosan/PEG hydrogel for intervertebral disc repair

Huang, Lin; Wang, Wantao; Xian, Yiwen; Liu, L.; Fan, Jean; Liu, Hongmei; Zheng, Zhaomin; Wu, Decheng

doi:10.1016/j.mtbio.2023.100752

Cited by 12 publications

(5 citation statements)

References 51 publications

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“…Rapid photocrosslinking gelation of methacrylate CS under 405 nm light irradiation. It can also be combined with dynamic imine bonds from Schiff base reactions between aldehydes and polyethylene glycols and can be rapidly formed in situ for intervertebral disc repair injectable CS/PEG hydrogels [ 66 ]. Preparation of injectable thermosensitive hydrogels based on polyacrylamide polyacrylic acid copolymers can be formed by cross-linking two precursor solutions of significantly different viscosities.…”

Section: Hydrogel Materialsmentioning

confidence: 99%

Repair of Infected Bone Defects with Hydrogel Materials

Cao,

Qin,

Duns

et al. 2024

Polymers

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Infected bone defects represent a common clinical condition involving bone tissue, often necessitating surgical intervention and antibiotic therapy. However, conventional treatment methods face obstacles such as antibiotic resistance and susceptibility to postoperative infections. Hydrogels show great potential for application in the field of tissue engineering due to their advantageous biocompatibility, unique mechanical properties, exceptional processability, and degradability. Recent interest has surged in employing hydrogels as a novel therapeutic intervention for infected bone repair. This article aims to comprehensively review the existing literature on the anti-microbial and osteogenic approaches utilized by hydrogels in repairing infected bones, encompassing their fabrication techniques, biocompatibility, antimicrobial efficacy, and biological activities. Additionally, the potential opportunities and obstacles in their practical implementation will be explored. Lastly, the limitations presently encountered and the prospective avenues for further investigation in the realm of hydrogel materials for the management of infected bone defects will be deliberated. This review provides a theoretical foundation and advanced design strategies for the application of hydrogel materials in the treatment of infected bone defects.

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Section: Hydrogel Materialsmentioning

confidence: 99%

Repair of Infected Bone Defects with Hydrogel Materials

Cao,

Qin,

Duns

et al. 2024

Polymers

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“…The imine bond can be reversibly broken, reorganized and exchanged under certain stimuli, giving the hydrogel material good self-healing and injectability. 46,47 Chemically crosslinked hydrogels have a stable structure and excellent mechanical properties due to the strong chemical bonding connections between the polymer chains. 48 However, toxic chemicals and difficulty in sanitizing may have adverse effects and certain insecurities.…”

Section: Hydrogels For Use In Bone Tissuementioning

confidence: 99%

Recent advances in composite hydrogels: synthesis, classification, and application in the treatment of bone defects

Zhang,

Qi,

Zhang

et al. 2024

Biomater. Sci.

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“…Cell culture experiments showed that CSMA-PEGDA-L has low cytotoxicity. Imaging studies conducted using a rat animal model revealed that the hydrogel effectively delayed IDD progression through physical blocking ( Huang et al., 2023 ).…”

Section: Treatment Of Aseptic Inflammationmentioning

confidence: 99%

From drugs to biomaterials: a review of emerging therapeutic strategies for intervertebral disc inflammation

Yang,

Jing,

Wang

et al. 2024

Front. Cell. Infect. Microbiol.

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Chronic low back pain (LBP) is an increasingly prevalent issue, especially among aging populations. A major underlying cause of LBP is intervertebral disc degeneration (IDD), often triggered by intervertebral disc (IVD) inflammation. Inflammation of the IVD is divided into Septic and Aseptic inflammation. Conservative therapy and surgical treatment often fail to address the root cause of IDD. Recent advances in the treatment of IVD infection and inflammation range from antibiotics and small-molecule drugs to cellular therapies, biological agents, and innovative biomaterials. This review sheds light on the complex mechanisms of IVD inflammation and physiological and biochemical processes of IDD. Furthermore, it provides an overview of recent research developments in this area, intending to identify novel therapeutic targets and guide future clinical strategies for effectively treating IVD-related conditions.

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Rapidly in situ forming an injectable Chitosan/PEG hydrogel for intervertebral disc repair

Cited by 12 publications

References 51 publications

Repair of Infected Bone Defects with Hydrogel Materials

Repair of Infected Bone Defects with Hydrogel Materials

Recent advances in composite hydrogels: synthesis, classification, and application in the treatment of bone defects

From drugs to biomaterials: a review of emerging therapeutic strategies for intervertebral disc inflammation

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