Rapidly Progressing, Massive Mitral Annular Calcification

DePace, Nicholas L.

doi:10.1001/archinte.1981.00340130101023

Cited by 33 publications

(1 citation statement)

References 9 publications

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“…In addition, organic valve disease may be an extrarenal complication of uraemia. Chronic renal fail ure is associated with an increased incidence of calcifica tion of the mitral valve annulus [2][3][4], which if severe may cause mitral stenosis or regurgitation [5,6]. Aortic valve calcification also occurs [7][8][9], but has received less atten tion probably because it is not considered to be of func tional importance.…”

Section: Introductionmentioning

confidence: 99%

Calcific Aortic Stenosis: A Complication of Chronic Uraemia

Maher

Pazianas

Curtis

1987

Nephron

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The incidence of aortic stenosis was studied in 174 consecutive patients aged < 55 years at initiation of maintenance haemodialysis. Severe, calcific aortic stenosis developed in 6 patients a mean 9.7 years after starting haemodialysis (p = 0.0004 compared to population incidence). In 5 patients stenosis was due to severe premature calcification of a tricuspid aortic valve. Necropsy proven aortic valve calcification (with or without stenosis) was associated with an increased duration of haemodialysis, age > 35 years at starting dialysis and mitral annular calcification. There is an increased incidence of aortic stenosis in patients with chronic renal failure due to premature valvular calcification, which may be related to abnormal calcium and phosphate metabolism in uraemia.

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