Rapidly progressive dementia and unilateral jerky movements: a case of Creutzfeldt-Jakob disease

Razmeh, Saeed; Almasi, Mostafa; Habibi, Amir Hasan; Alizadeh, Elham

doi:10.1136/postgradmedj-2016-134178

Cited by 2 publications

(8 citation statements)

References 3 publications

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“…The non-specific nature of CJD symptoms increases the risk of misdiagnosis ( Table 3 ). 8 , 12 – 22 Patient-4’s initial suspicion of Chiari malformation 15 and Patient-7’s diagnosis of an acute psychotic episode underscore the challenge in distinguishing CJD from other neurological or psychiatric conditions. Patient-11, 12 initially received antidepressants, further exemplifies the risk of overlooking CJD in the absence of specific diagnostic markers.…”

Section: Resultsmentioning

confidence: 99%

“…Thirteen cases from twelve studies were included to extract information for investigating CJD in Iranian patients (Table 1). 8,[12][13][14][15][16][17][18][19][20][21][22] The mean AE SD age of the 13 cases was 59.38 AE 7.44 years. The regional distribution of CJD cases in Iran, encompassing areas such as Tabriz, Mashhad, Tehran, Rafsanjan and Babol, indicates potential regional factors influencing CJD incidence and diagnosis.…”

Section: Resultsmentioning

confidence: 99%

“…The varied symptoms of the disease and the absence of specific diagnostic tests lead to delays or incorrect diagnoses (Table 2). 8,[12][13][14][15][16][17][18][19][20][21][22] Diagnosing CJD is difficult because its symptoms can imitate other neurological or mental health disorders. Patients with a final diagnosis of CJD exhibited cognitive impairment, which is consistent with the most common sporadic subtype of CJD.…”

Section: Resultsmentioning

confidence: 99%

“…15 The non-specific nature of CJD symptoms increases the risk of misdiagnosis (Table 3). 8,[12][13][14][15][16][17][18][19][20][21][22] Patient-4's initial suspicion of Chiari malformation 15 and Patient-7's diagnosis of an acute psychotic episode underscore the challenge in distinguishing The patient presented with depressive symptoms, confusion and disorientation over a period of 3 months before her admission to the hospital. b Patient-1 and patient-2 were from same hospital in Tabriz city.…”

Section: Resultsmentioning

confidence: 99%

“…The 13 patients with CJD exhibited diverse medical histories, ranging from no significant past medical history to conditions like ischaemic heart disease, benign prostatic hyperplasia and splenectomy (Table 4). 8,[12][13][14][15][16][17][18][19][20][21][22] Furthermore, family history appears to play a role in some cases as well. Patient-7 had a family history of schizophrenia and benign prostatic hyperplasia, while Patient-8 had a positive family history of depressive symptoms reported in her mother, along with a history of distress and depressive symptoms after a stressor, and a splenectomy due to a car crash 17 years prior to admission.…”

Section: Resultsmentioning

confidence: 99%

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Understanding Creutzfeldt-Jakob disease in Iran: a systematic review of case reports

Mohebbi,

Motamedaria,

Naderi

et al. 2024

J Int Med Res

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Objective To systematically review the reported cases of Creutzfeldt-Jakob disease (CJD) in Iran. Methods A comprehensive literature review of CJD cases in Iran was undertaken using the PubMed®, Scopus® and Google Scholar databases. In addition, the Iranian database MagIran was searched for Persian language reports. Case selection used the following criteria: (i) patients of Iranian origin; (ii) publication in peer-reviewed journals or reputable medical databases; (iii) a definitive diagnosis of CJD based on established diagnostic criteria. Results Thirteen cases from twelve reports were included in this systematic review. The majority of the cases were female (11 of 13; 84.6%). The mean ± SD age of patients at hospital admission was 59.38 ± 7.44 years. The findings of the case review suggested that the prevalence of CJD in Iran is not fully established. CJD may be misdiagnosed alongside other clinical signs. The most prevalent early indications of the disease were psychiatric and neurological in nature. A considerable delay in diagnosis was observed in some cases and there was a shortage of brain autopsy records. Conclusion Efforts to improve diagnostic capabilities, promote awareness and establish monitoring systems are necessary for managing the challenges of providing an early diagnosis of CJD in Iran.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Understanding Creutzfeldt-Jakob disease in Iran: a systematic review of case reports

Mohebbi,

Motamedaria,

Naderi

et al. 2024

J Int Med Res

View full text Add to dashboard Cite

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Parkinsonism as an initial presentation of Creutzfeldt‐Jakob disease: A case report and review of literature

Bahrami,

Karimi,

Khosravi

et al. 2024

Clinical Case Reports

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Key Clinical MessageCreutzfeldt‐Jakob disease (CJD) is a rapidly progressive, fatal neurodegenerative disorder. This case highlights parkinsonism as a rare initial manifestation of sporadic CJD (sCJD), emphasizing the need for heightened clinical awareness to prevent misdiagnosis. Early and accurate diagnosis of sCJD is crucial for preventing potential iatrogenic transmission and optimizing patient management.AbstractCreutzfeldt‐Jakob disease (CJD) is a fatal neurodegenerative illness. While movement disorders may be present at the onset of the disease in about half of those with sporadic CJD (sCJD), parkinsonism is a rare initial presentation. In this article, we report a case of CJD with parkinsonism as the initial presentation of the disease. We report a 69‐year‐old lady with initial symptoms of gait difficulty, tremor, and bradykinesia. Later, she developed cognitive impairment, ataxia, chin tremor, and myoclonic jerks. Her condition worsened to the point of akinetic mutism. She was diagnosed with probable sCJD after detecting protein 14‐3‐3 in her cerebrospinal fluid and observing typical imaging features.This case report illustrates important aspects of an inevitably fatal and rapidly progressing disease's early presentation and clinical features. The uncommon initial presentations of sCJD should be considered with the intent of preventing misdiagnosis in the future. Early diagnosis of sCJD can prevent possible iatrogenic disease transmission and improve patient care.

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Rapidly progressive dementia and unilateral jerky movements: a case of Creutzfeldt-Jakob disease

Cited by 2 publications

References 3 publications

Understanding Creutzfeldt-Jakob disease in Iran: a systematic review of case reports

Understanding Creutzfeldt-Jakob disease in Iran: a systematic review of case reports

Parkinsonism as an initial presentation of Creutzfeldt‐Jakob disease: A case report and review of literature

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