Rapidly Progressive Dementia as the First Symptom of Primary Hyperparathyroidism: A Case Report

Psychotic depression due to primary hyperparathyroidism

“…Primary hyperparathyroidism often occurs in women over the age of 50 years and can present with neuropsychiatric symptoms, including general apathy, anxiety, sleep disorders, personality change and cognitive impairment. [9][10][11] In samples of patients undergoing parathyroidectomy for primary hyperparathyroidism, these disturbances have been identified at a rate of 43.1%-53% for anxiety, 33%-62.1% for depression, 22% for thoughts of death or suicide, 51.9% for anger and irritability, 5%-20% for hallucinations and delusions, and 37.3%-46.5% for impaired cognition. 1,8,[12][13][14][15] Our patient presented with most of the symptoms described above, including anxiety, depression, suicidal thoughts, delusions, hallucinations and irritability.…”