Rapidly progressive glomerulonephritis in a patient with renal amyloidosis: Case report and review of the literature

Anupama, YJ; Vankalakunti, Mahesha

doi:10.4103/0971-4065.103931

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…In a review of recently published series and case reports on renal amyloid with crescents, 16 of 21 (76%) reported cases have been associated with AA amyloid, most commonly in patients with rheumatoid arthritis or underlying malignancies. 23 , 24 , 25 , 26 , 27 , 28 , 29 The remaining 5 (24%) occurred in AL amyloid, 23 , 25 , 26 , 28 1 in a patient with a positive anti-neutrophil cytoplasmic antibody. Crescents may be more common in cases of AA amyloid with concurrent glomerular Ig deposition.…”

Section: Discussionmentioning

confidence: 99%

AA amyloidosis With Ig-Dominant Staining and Diagnostically Unusual Features

Andeen,

DiFranza,

Kung

et al. 2024

Kidney International Reports

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Section: Discussionmentioning

confidence: 99%

AA amyloidosis With Ig-Dominant Staining and Diagnostically Unusual Features

Andeen,

DiFranza,

Kung

et al. 2024

Kidney International Reports

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A rare presentation of kidney failure in a patient with giant cell arteritis: case report and review of literature

Ginste

Dendooven

Dorpe

et al. 2020

Acta Clinica Belgica

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The proteome content of blood clots observed under different conditions: successful role in predicting clot amyloid(ogenicity)

Kell,

Pretorius

2024

Preprint

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A recent analysis compared the proteome of (i) blood clots seen in two diseases, viz. sepsis and long COVID, when blood was known to have clotted into an amyloid microclot form (as judged by staining with the fluorogenic amyloid stain thioflavin T) with (ii) that of those non-amyloid clots considered to have formed normally. Such fibrinaloid microclots are also relatively resistant to fibrinolysis. The proteins that the amyloid microclots contained differed markedly both from the soluble proteome of typical plasma and that of normal clots, and also between the disease studies (an acute syndrome in the form of sepsis in an ITU and a chronic disease represented by Long COVID). Many proteins in the amyloid microclots were low in concentration in plasma and were effectively accumulated into the fibres, whereas many other abundant plasma proteins were excluded. The proteins found in the microclots associated with the diseases also tended to be themselves amyloidogenic. We here ask effectively the inverse question. This is: can the clot proteome tell us whether the clots associated with a particular disease contained proteins that are observed uniquely (or are highly over-represented) in known amyloid clots relative to normal clots, and thus were in fact amyloid in nature? The answer is in the affirmative in a variety of major coagulopathies, viz. venous thromboembolism, pulmonary embolism, deep vein thrombosis, various cardiac issues, and ischaemic stroke. Galectin-3-binding protein and thrombospondin-1 seem to be especially widely associated with amyloid-type clots, and the latter has indeed been shown to be incorporated into growing fibrin fibres. These may consequently provide useful biomarkers with a mechanistic basis.

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Rapidly progressive glomerulonephritis in a patient with renal amyloidosis: Case report and review of the literature

Cited by 4 publications

References 12 publications

AA amyloidosis With Ig-Dominant Staining and Diagnostically Unusual Features

AA amyloidosis With Ig-Dominant Staining and Diagnostically Unusual Features

A rare presentation of kidney failure in a patient with giant cell arteritis: case report and review of literature

The proteome content of blood clots observed under different conditions: successful role in predicting clot amyloid(ogenicity)

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