Rare and unusual isolates of viridans streptococci from the human oral cavity

Dhotre, Shree; Suryawanshi, Namdev; Nagoba, Basavraj; Selkar, Sohan P

doi:10.4103/0377-4929.174817

Cited by 6 publications

(5 citation statements)

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“…Non-mutans streptococci represented the predominant commensals of the microbiota from oral swabs of WT and KO mice, consistent with previous observations in humans (Lazarevic et al, 2009) as well as laboratory mice (Chun et al, 2010). S. thoraltensis was isolated previously from human subgingival plaque of patients with periodontitis (Dhotre et al, 2016). S. azizii was earlier isolated from the oral cavity of inbred C57BL mice (Braden et al, 2015) and the uncultured species of streptococcus was found in the epidermis of mice, likely transferred orally during grooming (Grice et al, 2008).…”

Section: Amylase Expression In Humans and Cariessupporting

confidence: 88%

Murine Salivary Amylase Protects Against Streptococcus mutans-Induced Caries

2021

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Saliva protects dental surfaces against cavities (i. e., dental caries), a highly prevalent infectious disease frequently associated with acidogenic Streptococcus mutans. Substantial in vitro evidence supports amylase, a major constituent of saliva, as either protective against caries or supporting caries. We therefore produced mice with targeted deletion of salivary amylase (Amy1) and determined the impact on caries in mice challenged with S. mutans and fed a diet rich in sucrose to promote caries. Total smooth surface and sulcal caries were 2.35-fold and 1.79-fold greater in knockout mice, respectively, plus caries severities were twofold or greater on sulcal and smooth surfaces. In in vitro experiments with samples of whole stimulated saliva, amylase expression did not affect the adherence of S. mutans to saliva-coated hydroxyapatite and slightly increased its aggregation in solution (i.e., oral clearance). Conversely, S. mutans in biofilms formed in saliva with 1% glucose displayed no differences when cultured on polystyrene, but on hydroxyapatite was 40% less with amylase expression, suggesting that recognition by S. mutans of amylase bound to hydroxyapatite suppresses growth. However, this effect was overshadowed in vivo, as the recoveries of S. mutans from dental plaque were similar between both groups of mice, suggesting that amylase expression helps decrease plaque acids from S. mutans that dissolve dental enamel. With amylase deletion, commensal streptococcal species increased from ~75 to 90% of the total oral microbiota, suggesting that amylase may promote higher plaque pH by supporting colonization by base-producing oral commensals. Importantly, collective results indicate that amylase may serve as a biomarker of caries risk.

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Section: Amylase Expression In Humans and Cariessupporting

confidence: 88%

Murine Salivary Amylase Protects Against Streptococcus mutans-Induced Caries

2021

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“…Our patient worked in an auto repair shop, had an indoor cat and had no exposure to farm animals. Dhotre S et al report S. pluranimalium being isolated from subgingival dental plaque of a patient with periodontitis following tooth extraction [15]. An extensive literature review revealed that the bacterium was isolated from a blood culture in a patient after dental piezocision procedure following transient bacteremia (with negative blood culture before the procedure) [16].…”

Section: Discussionmentioning

confidence: 99%

Streptococcus pluranimalium infective endocarditis and brain abscess

Duriseti

Fleisher

2019

IDCases

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Infective endocarditis is an infection of the endocardium of the heart typically seen in individuals with underlying risk factors. We report a rare case of Streptococcus pluranimalium bacteremia causing infective endocarditis and brain abscess. Only 3 cases were reported in the literature on infective endocarditis in patients secondary to S. pluranimalium .

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“…Identification of the bacterium was performed using the Vitek 2 system, similar to our article. Analysis of the antimicrobial resistance of Streptococcus thoraltensis isolated from patients with periodontitis showed resistance to ampicillin, cefepime, cefotaxime, and ceftriaxone [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…We included nine papers that describe infections produced by Streptococcus thoraltensis, emphasizing the heterogenicity of the infections this pathogen may produce [22][23][24][25][26][27][28][29][30].…”

Section: Discussionmentioning

confidence: 99%

Vancomycin-Resistant Streptococcus thoraltensis: A Case Report of Bacterial Endocarditis and Review of Literature on Infections Caused by This Pathogen

Chiorescu,

Buksa,

Botan

et al. 2024

Microorganisms

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Streptococcus thoraltensis is a rare species, part of the viridans streptococcus group, found initially in rabbits and pigs, which can be vancomycin-resistant. We present the case of a 65-year-old patient, a smoker and chronic alcohol consumer with chronic obstructive pulmonary disease (COPD) and multiple dental foci who had been diagnosed with bacterial endocarditis caused by Streptococcus thoraltensis. The particular elements of the case consisted of an atypical clinical presentation with diarrheal stools, abdominal pain, concomitant damage to the aortic and tricuspid valves, the presence of large vegetations (>2 cm), and a vancomycin-resistant strain of Streptococcus thoraltensis. The evolution of the patient was unfavorable due to septic embolisms, respiratory failure requiring orotracheal intubation, and septic and cardiogenic shock. Infections with Streptococcus thoraltensis are challenging to treat because of the severity of the clinical form it causes and the pattern of antibiotic resistance in this germ. Based on our brief review, Streptococcus thoraltensis is an extremely rare human pathogen previously described as the etiologic agent of infectious endocarditis in only one case.

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Rare and unusual isolates of viridans streptococci from the human oral cavity

Abstract: To the best of our knowledge, this is the first report of isolation of these rare and unusual strains from the human oral cavity.

Cited by 6 publications

References 0 publications

Murine Salivary Amylase Protects Against Streptococcus mutans-Induced Caries

Murine Salivary Amylase Protects Against Streptococcus mutans-Induced Caries

Streptococcus pluranimalium infective endocarditis and brain abscess

Vancomycin-Resistant Streptococcus thoraltensis: A Case Report of Bacterial Endocarditis and Review of Literature on Infections Caused by This Pathogen

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