Rare association of aortoarteritis and pheochromocytoma: A case report

Toutai, Chaimae; Berrajaa, Mehdi; Aissaoui, Hanane; Elouafi, Noha; Jabi, Rachid; Bouziane, Mohammed; Latrech, H.; Housni, Brahim; Ismaili, Nabila

doi:10.1016/j.ijscr.2020.10.048

Cited by 3 publications

(4 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sarathi et al [62], studying the relationship between catecholamines and vasculitis, found a correlation between pheochromocytoma and aortoarteritis, and thus demonstrated the essential role of catecholamines in the development of aortoarteritis. This aspect has been recently confirmed by Toutai et al, who stated that high catecholamine levels may have a role in the etiopathogenesis of aortoarteritis in these patients [63].…”

Section: Catecholamine Concentrationsupporting

confidence: 53%

Recent Updates and Advances in Winiwarter-Buerger Disease (Thromboangiitis Obliterans): Biomolecular Mechanisms, Diagnostics and Clinical Consequences

et al. 2021

View full text Add to dashboard Cite

Thromboangiitis obliterans (TAO) or Buerger’s disease is a segmental inflammatory, thrombotic occlusive peripheral vascular disease with unknown aetiology that usually involves the medium and small-sized vessels of young male smokers. Due to its unknown aetiology and similarities with atherosclerosis and vasculitis, TAO diagnosis is still challenging. We aimed to review the status of biomolecular and laboratory para-clinical markers in TAO compared to atherosclerosis and vasculitis. We reported that, although some biomarkers might be common in TAO, atherosclerosis, and vasculitis, each disease occurs through a different pathway and, to our knowledge, there is no specific and definitive marker for differentiating TAO from atherosclerosis or vasculitis. Our review highlighted that pro-inflammatory and cell-mediated immunity cytokines, IL-33, HMGB1, neopterin, MMPs, ICAM1, complement components, fibrinogen, oxidative stress, NO levels, eNOS polymorphism, adrenalin and noradrenalin, lead, cadmium, and homocysteine are common markers. Nitric oxide, MPV, TLRs, MDA, ox-LDL, sST2, antioxidant system, autoantibodies, and type of infection are differential markers, whereas platelet and leukocyte count, haemoglobin, lipid profile, CRP, ESR, FBS, creatinine, d-dimer, hypercoagulation activity, as well as protein C and S are controversial markers. Finally, our study proposed diagnostic panels for laboratory differential diagnosis to be considered at first and in more advanced stages.

show abstract

Section: Catecholamine Concentrationsupporting

confidence: 53%

Recent Updates and Advances in Winiwarter-Buerger Disease (Thromboangiitis Obliterans): Biomolecular Mechanisms, Diagnostics and Clinical Consequences

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Indeed, cases of aorto-arteritis have been reported as complications of pheochromocytoma in young adults for whom symptoms lasted for months. The complex and multi-factorial mechanisms causing aortic wall inflammation involve mechanical stress due to systemic systolic hypertension and aortic wall ischemia due to vasa vasorum constriction leading in turn to media necrosis and elastic layer destruction [ 20 ]. A catecholamine triggered auto-immune disease has also been proposed as a possible cause of aortic wall damage since high titers of lupus erythematosus auto-antibodies were measured in patients with pheochromocytoma and normalized after tumor resection [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Unusual Cardiac Manifestations of a Pheochromocytoma in a Girl

et al. 2023

View full text Add to dashboard Cite

We report the case of an 11-year-old girl who complained about severe asthenia, orthostatic dizziness and abdominal pain for 4 weeks. The primary investigation concluded on febrile urinary tract infection treated by antibiotics. Symptom persistence prompted cardiological and endocrinological investigations. A fluctuation in blood pressure, long QT interval, dilation of the aortic root and left ventricular hypertrophy were documented. Elevated levels of urinary catecholamines together with the presence of a right-sided adrenal mass shown via abdominal ultrasound and magnetic resonance imaging were highly suggestive of a pheochromocytoma. This was confirmed by through iodine-123-metaiodobenzylguathdine ([123I]-mIBG) scintigraphy. Genetic analysis allowed for the exclusion of pathogenic mutations in genes implicated in hereditary paragangliomas and pheochromocytomas but showed a rare somatic mutation in exon 3 of the von Hippel-Lindau gene. The patient was treated with a β-blocker and calcium channel antagonist and underwent laparoscopic right-sided adrenalectomy. Cardiac manifestations resolved soon after surgery indicating that they were secondary to the pheochromocytoma. After 5 years of follow-up, the patient remains asymptomatic without any sign of tumor recurrence. The presence of aortic root dilation, a prolonged QT-interval and left ventricular hypertrophy may be early cardiac manifestations of a pheochromocytoma in a child and should prompt this diagnosis to be evoked.

show abstract

“…TAK is a disease characterized by inflammation of the blood vessel wall that primarily affects the aortic arteries, such as the aorta and its main branches 19 . Research results showed that immune disorders, especially cellular immunity disorders, were the basis for the pathogenesis of TAK 20 . According to the 2021 ACR guidelines for TAK, the use of immunosuppressive agents with glucocorticoids was recommended as initial therapy 21 .…”

Section: Discussionmentioning

confidence: 99%

“…19 Research results showed that immune disorders, especially cellular immunity disorders, were the basis for the pathogenesis of TAK. 20 According to the 2021 ACR guidelines for TAK, the use of immunosuppressive agents with glucocorticoids was recommended as initial therapy. 21 Then, the biologics such as tocilizumab and tumor necrosis factor (TNF) inhibitor can be added to the treatments.…”

Section: Discussionmentioning

confidence: 99%

Systemic review and meta‐analysis of the association between interleukin‐10 and Takayasu arteritis

Zhou

Liang

et al. 2023

Int J of Rheum Dis

View full text Add to dashboard Cite

Takayasu arteritis (TAK) is a chronic, large-vessel systemic vasculitis, 1 which affects large arteries, such as the aorta and its major branches and the pulmonary arteries. TAK mainly occurs in young adults, and may even affect children. 2 This disease occurs in both genders, but is more common in women during the second and third decades. TAK is distributed globally, with a greater prevalence in Asia. The variation in incidence and age of diagnosis among different ethnic groups is considerable. 3 In the acute phase of TAK, intima thickens with fibroblasts due to inflammation and mucopolysaccharide deposition. In the chronic phase, vascular fibrosis, vascular stenosis and occlusion, aneurysmal dilation occur in the aorta and major branches, which leads to hypertension, renal artery stenosis, pulmonary hypertension and congestive heart failure. 3 Interleukin (IL)-10 is a prototypical anti-inflammatory cytokine which plays a role in the maintenance and restoration of immunological homeostasis. Also, it can enhance the immune responses. 4

show abstract

Rare association of aortoarteritis and pheochromocytoma: A case report

Cited by 3 publications

References 15 publications

Recent Updates and Advances in Winiwarter-Buerger Disease (Thromboangiitis Obliterans): Biomolecular Mechanisms, Diagnostics and Clinical Consequences

Recent Updates and Advances in Winiwarter-Buerger Disease (Thromboangiitis Obliterans): Biomolecular Mechanisms, Diagnostics and Clinical Consequences

Unusual Cardiac Manifestations of a Pheochromocytoma in a Girl

Systemic review and meta‐analysis of the association between interleukin‐10 and Takayasu arteritis

Contact Info

Product

Resources

About